Chromosome Translocation
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Chromosome Translocation
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Author : Yu Zhang
language : en
Publisher: Springer
Release Date : 2018-06-28
Chromosome Translocation written by Yu Zhang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-28 with Medical categories.
This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases. The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation. It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.
Genetic Translocations And Other Chromosome Aberrations
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Author : Guy T. Leyden
language : en
Publisher: Nova Publishers
Release Date : 2008
Genetic Translocations And Other Chromosome Aberrations written by Guy T. Leyden and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Chromosome abnormalities categories.
Chromosomal aberrations are disruptions in the normal chromosomal content of a cell, and are a major cause of genetic conditions in humans, such as Down syndrome. Some chromosome abnormalities do not cause disease in carriers, such as translocations, or chromosomal inversions, although they may lead to a higher chance of having a child with a chromosome disorder. Abnormal numbers of chromosomes or chromosome sets, aneuploidy, may be lethal or give rise to genetic disorders. Genetic counseling is offered for families that may carry a chromosome rearrangement. This book offers leading-edge research from around the world.
Chromosomal Translocations And Genome Rearrangements In Cancer
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Author : Janet D. Rowley
language : en
Publisher: Springer
Release Date : 2015-12-09
Chromosomal Translocations And Genome Rearrangements In Cancer written by Janet D. Rowley and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-09 with Medical categories.
This volume collates world experts’ insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible. The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations and which launched a field in cancer genetics. Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours. Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.
Chromosomal Translocations And Genome Rearrangements In Cancer
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Author : Janet D. Rowley
language : en
Publisher:
Release Date : 2015
Chromosomal Translocations And Genome Rearrangements In Cancer written by Janet D. Rowley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
This volume collates world experts' insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible. The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations, and which launched a field in cancer genetics. Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours. Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.
Spontaneous Chromosome Translocations In Cattle And Pigs
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Author : Wm Allan King
language : en
Publisher:
Release Date : 1980
Spontaneous Chromosome Translocations In Cattle And Pigs written by Wm Allan King and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Cattle categories.
Chromosomal Instability In Cancer Cells
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Author : B. Michael Ghadimi
language : en
Publisher: Springer
Release Date : 2015-09-16
Chromosomal Instability In Cancer Cells written by B. Michael Ghadimi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-16 with Medical categories.
This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
Chromosomal Translocations And Oncogenic Transcription Factors
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Author : Frank J. III Rauscher
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Chromosomal Translocations And Oncogenic Transcription Factors written by Frank J. III Rauscher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.
Oncogenes As Transcriptional Regulators
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Author : Moshe Yaniv
language : en
Publisher: Springer Science & Business Media
Release Date : 1997
Oncogenes As Transcriptional Regulators written by Moshe Yaniv and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
1 E2Fs and the Retinoblastoma Protein Family.- 2 Signalling to the C-terminus of p53.- 3 Chromosome Translocations Generating Chimeric Transcription Factors, Unique Genetic Events with Pleiotropic Cellular Consequences.- 4 The Runt Domain Transcription Factor, PEBP2/CBF, and its Involvement in Human Leukemia.- 5 EBNA2: A Viral Transcription Factor Essential for the Immortalization of Human B Lymphocytes by the Epstein-Barr Virus (EBV).
Translocation In Human Chromosomes With Special Reference To Mental Retardation And Congenital Malformations
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Author : Anton Brøgger
language : en
Publisher:
Release Date : 1967
Translocation In Human Chromosomes With Special Reference To Mental Retardation And Congenital Malformations written by Anton Brøgger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1967 with Chromosome abnormalities categories.
Chromosomal Variation In Man
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Author : Digamber S. Borgaonkar
language : en
Publisher: John Wiley & Sons
Release Date : 1984
Chromosomal Variation In Man written by Digamber S. Borgaonkar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Science categories.