Chronic Myelocytic Leukemia And Interferon
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Chronic Myelocytic Leukemia And Interferon
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Author : Dieter Huhn
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Chronic Myelocytic Leukemia And Interferon written by Dieter Huhn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Studies on the effect of recombinant human interferon (rIFN) on the growth of colonies of multi potential hematopoietic progenitors have demonstrated that IFN inhibits the growth of these cells in culture. The inhibitory effect of IFN was more pronounced in multilineage colony forming cells (CFU-GEMMT) of marrow cells of patients with chronic myelogenous leukemia (CML) compared with stern cells of normal marrow. T cell colony formation (CFU-TL) of phi_positive T cells obtained from primary multilineage hematopoietic colonies was inhibited by rIFN. Inhibition of T cell colony formation of Phi T cells was more profound by IFN compared with secondary T cells of healthy individuals. Southern blot analysis of secondary T cells from normal individuals revealed a germ line pattern when examined for T cell receptor (TcR) gene re arrangements using the cDNA of the beta chain. Subcloned Phi T cells of one patient with CML demonstrated gene rearrangements of the TcR. We also demonstrated the disappearance of phi_positive multilineage hematopoietic colonies when marrow cells were preincubated with IFN and subsequently cultured in the presence of IFN. The cytoconversion of the Phi chromosome in metaphases obtained from individually analyzed multilineage hematopoietic colonies suggests that IFN might allow the restoration of nonclonal hematopoiesis in patients with CML. Acknowledgement. Supported in part by Deutsche Forschungsgemeinschaft and the Medical Research Council of Canada. References 1. Koeffler HP, Golde DW (1981) Chronic myelogenous 1eukelnia - new concepts.
Chronic Myelocytic Leukemia And Interferon
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Author : Dieter Huhn
language : en
Publisher: Springer
Release Date : 1988-06-08
Chronic Myelocytic Leukemia And Interferon written by Dieter Huhn and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-06-08 with Medical categories.
Studies on the effect of recombinant human interferon (rIFN) on the growth of colonies of multi potential hematopoietic progenitors have demonstrated that IFN inhibits the growth of these cells in culture. The inhibitory effect of IFN was more pronounced in multilineage colony forming cells (CFU-GEMMT) of marrow cells of patients with chronic myelogenous leukemia (CML) compared with stern cells of normal marrow. T cell colony formation (CFU-TL) of phi_positive T cells obtained from primary multilineage hematopoietic colonies was inhibited by rIFN. Inhibition of T cell colony formation of Phi T cells was more profound by IFN compared with secondary T cells of healthy individuals. Southern blot analysis of secondary T cells from normal individuals revealed a germ line pattern when examined for T cell receptor (TcR) gene re arrangements using the cDNA of the beta chain. Subcloned Phi T cells of one patient with CML demonstrated gene rearrangements of the TcR. We also demonstrated the disappearance of phi_positive multilineage hematopoietic colonies when marrow cells were preincubated with IFN and subsequently cultured in the presence of IFN. The cytoconversion of the Phi chromosome in metaphases obtained from individually analyzed multilineage hematopoietic colonies suggests that IFN might allow the restoration of nonclonal hematopoiesis in patients with CML. Acknowledgement. Supported in part by Deutsche Forschungsgemeinschaft and the Medical Research Council of Canada. References 1. Koeffler HP, Golde DW (1981) Chronic myelogenous 1eukelnia - new concepts.
Chronic Myelocytic Leukemia And Interferon
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Author : Dieter Huhn
language : en
Publisher: Springer
Release Date : 1988-01-01
Chronic Myelocytic Leukemia And Interferon written by Dieter Huhn and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-01-01 with Medical categories.
Chronic Myelocytic Leukemia And Interferon
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Author : Dieter Huhn
language : en
Publisher:
Release Date : 1988-06-08
Chronic Myelocytic Leukemia And Interferon written by Dieter Huhn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-06-08 with categories.
Interferon In The Treatment Of Chronic Myeloid Leukemia
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Author :
language : en
Publisher:
Release Date : 1993
Interferon In The Treatment Of Chronic Myeloid Leukemia written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
Interferon In The Treatment Of Chronic Myeloid Leukemia
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Author : Matthew Freund
language : en
Publisher:
Release Date : 1993
Interferon In The Treatment Of Chronic Myeloid Leukemia written by Matthew Freund and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Interferon categories.
Chronic Myeloid Leukemia
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Author : Rüdiger Hehlmann
language : en
Publisher: Springer Nature
Release Date : 2021-06-02
Chronic Myeloid Leukemia written by Rüdiger Hehlmann and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-02 with Medical categories.
This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the impact of availability of generic imatinib.
Interferon In The Treatment Of Chronic Myeloid Leukemia
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Author :
language : en
Publisher:
Release Date : 1993
Interferon In The Treatment Of Chronic Myeloid Leukemia written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
Medical Management Of Chronic Myelogenous Leukemia
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Author : Moshe Talpaz
language : en
Publisher: CRC Press
Release Date : 1998-10-01
Medical Management Of Chronic Myelogenous Leukemia written by Moshe Talpaz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-10-01 with Medical categories.
This valuable reference provides a timely summary of current therapies for chronic myelogenous leukemia (CML), discussing both basic pathophysiology and new experimental strategies. Combining the insights of over 30 prominent researchers in the field, Medical Management of Chronic Myelogenous Leukemia compares interferon therapy with conventional chemotherapy covers chronic, accelerated, and Philadelphia-negative phases details standard therapy with IFN- regimens and allogenic stem cell transplantation describes the utility and limitations of CML animal models profiles clinical trials testing IFN in combination with other agents assesses improvements in survival times among CML patients reviews the effectiveness of Southern blot monitoring traces the development of oligonucleotides as potential therapeutic agents outlines therapy with monoclonal antibodies, targeted NK cells, and immune T cells and more! Containing over 1500 references, tables, drawings, and photographs, Medical Management of Chronic Myelogenous Leukemia is suitable for clinical oncologists, hematologists, immunologists and researchers in the fields of tumor immunology and cancer immunotherapy, internists, and residents, fellows, and medical school students in these disciplines.
Interferon In The Treatment Of Chronic Myeloid Leukemia
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Author :
language : en
Publisher:
Release Date : 1993
Interferon In The Treatment Of Chronic Myeloid Leukemia written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.