Circadian Rhythms And Their Impact On Aging
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Circadian Rhythms And Their Impact On Aging
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Author : S. Michal Jazwinski
language : en
Publisher: Springer
Release Date : 2017-10-24
Circadian Rhythms And Their Impact On Aging written by S. Michal Jazwinski and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-24 with Medical categories.
Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.
Circadian Clock And Aging
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Author : Syed Ibrahim Rizvi
language : en
Publisher: Springer Nature
Release Date : 2024-10-15
Circadian Clock And Aging written by Syed Ibrahim Rizvi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-15 with Science categories.
This book aims to understand the inherent circadian cycles of biological processes and their role in maintaining health and healing a variety of diseases. The book is divided into eight sections. The first section introduces circadian rhythms and aging. The second section focuses on the detailed mechanistic approach of oscillatory pathways in mammals. The next section summarizes the sensitivity of the biological clock towards light and the circadian response to melatonin in mammals. The fourth section addresses the circadian architecture at the cellular level and introduces an age-dependent experimental model of rodents for subsequent biochemical and molecular investigations. The subsequent section covers the complexity of circadian regulation in mitochondrial dynamics and its impact on aging. The sixth section of the book discusses the findings obtained from different experimental approaches as a critical threat to the functioning of clock regulatory mechanisms and its associated health consequences during aging in humans and animal models. The circadian oscillatory mechanisms that are dysregulated and might play an important role in the development and progression of neurological disorders such as Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), and Amyotrophic Lateral Sclerosis (ALS), etc are discussed in the next section. Towards the end, the book explores the circadian clock as a possible drug target to restore circadian oscillations.
Human Circadian Physiology
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Author : Charles A. Czeisler
language : en
Publisher:
Release Date : 1978
Human Circadian Physiology written by Charles A. Czeisler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Human physiology categories.
The Rhythms Of Life
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Author : Leon Kreitzman
language : en
Publisher: Profile Books
Release Date : 2011-09-30
The Rhythms Of Life written by Leon Kreitzman and has been published by Profile Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-30 with Science categories.
Popular science at its most exciting: the breaking new world of chronobiology - understanding the rhythm of life in humans and all plants and animals. The entire natural world is full of rhythms. The early bird catches the worm -and migrates to an internal calendar. Dormice hibernate away the winter. Plants open and close their flowers at the same hour each day. Bees search out nectar-rich flowers day after day. There are cicadas that can breed for only two weeks every 17 years. And in humans: why are people who work anti-social shifts more illness prone and die younger? What is jet-lag and can anything help? Why do teenagers refuse to get up in the morning, and are the rest of us really 'larks' or 'owls'? Why are most people born (and die) between 3am-5am? And should patients be given medicines (and operations) at set times of day, because the body reacts so differently in the morning, evening and at night? The answers lie in our biological clocks the mechanisms which give order to all living things. They impose a structure that enables us to change our behaviour in relation to the time of day, month or year. They are reset at sunrise and sunset each day to link astronomical time with an organism's internal time.
Sleep And Aging
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Author : Mark P. Mattson
language : en
Publisher: Elsevier
Release Date : 2005-06-20
Sleep And Aging written by Mark P. Mattson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-20 with Medical categories.
The book describes the mechanisms involved in the maintenance of neuroendocrine-immune interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immune response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity
Sleep And Cognition In The Elderly
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Author : Géraldine Rauchs
language : en
Publisher: Frontiers Media SA
Release Date : 2015-05-26
Sleep And Cognition In The Elderly written by Géraldine Rauchs and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-26 with Medicine (General) categories.
Understanding the role of sleep and the mechanisms at play in ageing are among the most exciting challenges in neuroscience. Although our understanding of the mechanisms governing sleep stages and their role in cognitive processes including memory functions is gradually increasing. most of the currently available data have been gathered in young adults. Still, substantial physiological changes in sleep are observed with increasing age, that may markedly impacts on daily functioning. This is why this Research Topic focuses on our current understanding of the impact of age-related changes in sleep architecture on various domains of cognition. The three editors Julie Carrier (Montréal, Canada), Philippe Peigneux (Brussels, Belgium) and Géraldine Rauchs (Caen, France) are specialized in various fields of sleep research. Here, they bring together an outstanding group of neuroscientist and clinical investigators engaged in the study of sleep, encompassing state-of-the-art studies of sleep disorders such as sleep apnoea or REM sleep behaviour disorder, studies assessing new treatments to improve sleep quality, together with experts in various domains of cognition such as vigilance, memory and dreams, in a perspective aimed at offering the interested reader a comprehensive view of the impact of age-related changes in sleep architecture on cognition.
Circadian Rhythms Sleep And Inflammation
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Author : Pawan K. Jha
language : en
Publisher: Springer Nature
Release Date : 2025-01-01
Circadian Rhythms Sleep And Inflammation written by Pawan K. Jha and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-01 with Science categories.
The circadian clock is a complex cellular mechanism that controls numerous key physiological processes and maintains cellular, tissue, and systemic homeostasis. Disruption of the clock system influences the immune response and brain functions. Immune activation is closely linked with inflammation, neurodegeneration, aging, and other peripheral and central nervous system-related abnormalities. There is increasing evidence that cellular inflammation affects sleep and circadian rhythms and vice-versa. This book offers a structured overview that focuses on the multi-angle interaction of circadian rhythms, sleep, and inflammatory response in normal or pathological conditions.
Development Of Circadian Clock Functions Volume Ii
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Author : Daisuke Ono
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-31
Development Of Circadian Clock Functions Volume Ii written by Daisuke Ono and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-31 with Science categories.
The temporal order of physiological functions such as sleep/wakefulness is regulated by the circadian clock. This intrinsic clock starts ticking in the embryo and matures during development, with attenuation of the clock function in the elderly, illustrated by attenuation of synchrony, entrainment, and outputs of cellular circadian rhythms in the SCN. This age-related diminution can contribute to the emergence of diseases, such as sleep disorders, infertility, diabetes, mental disorders etc. Over the course of our lives, a variety of internal and external factors are under the influence of the circadian clock. This inherent developmental plasticity of the circadian system is critical for the establishment of normal bodily functions to adapt to the changing environment on earth. In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Circadian rhythms in the SCN are observed during the embryonic period, and input and output pathways from the SCN are formed after birth. During postnatal development, functions of neurotransmitters in the SCN are changed, which have an influence on special temporal patterns of circadian rhythms in the SCN and outputs signals to the outside of the SCN. During postnatal development properties of circadian rhythms in the SCN and its inputs and outputs can be modulated by environmental light conditions. Recent optical manipulation and imaging techniques have revealed that cell type specific functions for circadian rhythms. However, it remains unclear which cell types or networks in the brain are modulated during postnatal development, and how these cells regulate circadian rhythms depending on postnatal period.
Anti Aging Pharmacology
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Author : Vitaly Koltover
language : en
Publisher: Academic Press
Release Date : 2022-12-07
Anti Aging Pharmacology written by Vitaly Koltover and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-07 with Medical categories.
Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm. This book contains the work of the world's leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice. - Includes updated information about current developments in anti-aging pharmacology - Offers practical advice on the applicability of certain healthspan-promoting medications - Discusses potential challenges related to the translation of anti-aging drugs in clinical practice
Conn S Handbook Of Models For Human Aging
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Author : Jeffrey L. Ram
language : en
Publisher: Academic Press
Release Date : 2018-04-05
Conn S Handbook Of Models For Human Aging written by Jeffrey L. Ram and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-05 with Medical categories.
Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. - Combines both the methods of study for human aging and animal models - Provides a historical overview and discussion of model availability, key methods and ethical issues - Contains over 200 full color illustrations