Circulating Nucleic Acids In Plasma And Serum Iv

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Circulating Nucleic Acids In Plasma And Serum Iv

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Author : R. Swaminathan
language : en
Publisher: Wiley-Blackwell
Release Date : 2006-10-09

Circulating Nucleic Acids In Plasma And Serum Iv written by R. Swaminathan and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-09 with Science categories.

An accurate, inexpensive, and noninvasive method for the early diagnosis of cancer has been something of a holy grail among cancer researchers, but until recently a method meeting all three criteria has been elusive. Nucleic acids were first discovered in circulation in 1948, but it was not until the 1960s and 70s that patients with autoimmune disease and cancer were discovered to have higher levels of circulating DNA than were detected in in healthy persons. The focus in this volume is on three major applications of the circulating nucleic acids detection method: cancer, fetal medicine, and diseases such as diabetes, stroke, and myocardial infarction. In addition, there are reports on the biology and origins of circulating DNA and RNA and on improved methods for the detection of nucleic acids in plasma and serum. The circulating DNA found in cancer patients has many characteristics in common with their tumors, which made it an attractive candidate for use in the diagnosis and management of patients with malignancies. This method can also be applied to the assessment of the sublinical tumor burden in cancer patients, thus reducing the risk of unnecessary chemotherapy. Detection of nucleic acids circulating in maternal serum means that fetal diagnosis may be possible without resorting to the more dangerous and invasive methods now used (e.g., amniotic fluid and chorionic villus sampling). Detection of problems in the pregnancy such as preeclampsia and intrauterine growth retardation may also become possible through maternal blood samples. In diabetic patients, circulating nucleic acids can be used for the early detection of developments such as retinopathy. The benefits of using circulating nucleic acids in the diagnosis and management of cancer and chronic disease will be realized through earlier detection by means of this less expensive and less invasive testing technique and through its potential for closer monitoring of the disease. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Circulating Nucleic Acids In Plasma And Serum

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Author : Peter B. Gahan
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-08

Circulating Nucleic Acids In Plasma And Serum written by Peter B. Gahan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-08 with Medical categories.

DNA and RNA fractions have been isolated from the whole blood, serum, plasma, the surface of blood cells, urine, saliva and spinal fluid from both healthy individuals and clinical patients. Recent developments are presented concerning the isolation, quantification and analysis of these molecules and their use in the identification of specific nucleic acid fragments related to a variety of clinical disorders thereby permitting their early diagnosis and prognosis.

Circulating Nucleic Acids In Serum And Plasma Cnaps Ix

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Author : Peter B. Gahan
language : en
Publisher: Springer
Release Date : 2016-10-17

Circulating Nucleic Acids In Serum And Plasma Cnaps Ix written by Peter B. Gahan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-17 with Medical categories.

The book will present the progress made since the last meeting in fall 2013 concerning the analysis of circulating extra-cellular nucleic acids. There are a modest number of laboratories involved in this field, nevertheless the number of papers published by researchers is extensive. The articles which will be published in this meeting report will be a valuable contribution for researchers and research students alike and will help them to stay on top of the developments in different research areas and to „cross borders“ between them.

Circulating Nucleic Acids In Plasma And Serum

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Author :
language : en
Publisher: Springer
Release Date : 2011-07-11

Circulating Nucleic Acids In Plasma And Serum written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-11 with categories.

Circulating Nucleic Acids In Plasma Or Serum

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Author : Philippe Anker
language : en
Publisher:
Release Date : 2000

Circulating Nucleic Acids In Plasma Or Serum written by Philippe Anker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.

Free DNA present in both healthy and diseased human plasma has been found to express specific point mutations that may serve as diagnostic signposts - perhaps to reliable, non-invasive tests for breast and lung cancer, haematopoetic malignancies, colorectal or pancreatic carcinoma, and other tumours. In another research area, foetal DNA has been detected in maternal serum which presents an early-horizon alternative in utero test for gender. A parallel discovery of rearranged immunoglobin heavy-chain DNA in the plasma of patients wit Hodgkin's disease or acute B cell leukaemia has also emerged. These fast-emerging indicators suggest that it is time to standardize research techniques and develop protocols that can take a measure of circulating DNA's usefulness as a diagnostic tool. This volume, taken from the proceedings of a conference in August 1999, discusses such issues.

Annals Of The New York Academy Of Sciences Circulating Nucleic Acids In Plasma And Serum V

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Author : Peter Gahan
language : en
Publisher: Wiley-Blackwell
Release Date : 2008-10-20

Annals Of The New York Academy Of Sciences Circulating Nucleic Acids In Plasma And Serum V written by Peter Gahan and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-20 with Science categories.

DNA and RNA fractions have been isolated from whole blood, serum, plasma, the surface of blood cells, and urine from both healthy persons and patients. Specific fragments have been identified as being related to particular disorders, for example, diabetes, cancer, myocardial infarction, and stroke. The ability to isolate these fractions and assess their relationship to specific diseases makes early noninvasive diagnosis possible. This volume reports on the most recent progress in this field, including chapters on developing protocols for nucleic acid extraction, determining the origin of the circulating nucleic acids, the capacity of these nucleic acids to enter cells and exhibit biological activity, isolating and testing fetal cells from maternal blood, and discussing the clinical implications of these discoveries and developing the techniques that will bring them into clinical application. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Annals Of The New York Academy Of Sciences Circulating Nucleic Acids In Plasma And Serum V

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Author : Peter Gahan
language : en
Publisher: Wiley-Blackwell
Release Date : 2008-10-20

Annals Of The New York Academy Of Sciences Circulating Nucleic Acids In Plasma And Serum V written by Peter Gahan and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-20 with Science categories.

DNA and RNA fractions have been isolated from whole blood, serum, plasma, the surface of blood cells, and urine from both healthy persons and patients. Specific fragments have been identified as being related to particular disorders, for example, diabetes, cancer, myocardial infarction, and stroke. The ability to isolate these fractions and assess their relationship to specific diseases makes early noninvasive diagnosis possible. This volume reports on the most recent progress in this field, including chapters on developing protocols for nucleic acid extraction, determining the origin of the circulating nucleic acids, the capacity of these nucleic acids to enter cells and exhibit biological activity, isolating and testing fetal cells from maternal blood, and discussing the clinical implications of these discoveries and developing the techniques that will bring them into clinical application. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Circulating Nucleic Acids In Early Diagnosis Prognosis And Treatment Monitoring

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Author : Peter B. Gahan
language : en
Publisher: Springer
Release Date : 2014-11-18

Circulating Nucleic Acids In Early Diagnosis Prognosis And Treatment Monitoring written by Peter B. Gahan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-18 with Medical categories.

DNA and RNA fractions can be isolated from a variety of body fluids including whole blood, serum, plasma, urine, saliva and cerebrospinal fluid from both patients and healthy individuals. Such isolates can be exploited in the early detection of clinical disorders, stratification of patients for treatment, treatment monitoring and clinical follow-up. In addition, the use in fetal medicine allows the early detection of fetal sex, Rh factor and aneuploid disorders as well as following both fetal and premature born infant development. This volume is intended as a primer for those who are interested in entering the field of circulating nucleic acids. The areas covered in this volume include: · Background and general biology of circulating nucleic acids · Methodology · Applications of circulating nucleic acids · Quality Assurance · Ethics

Circulating Nucleic Acids In Plasma Serum Iii And Serum Proteomics

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Author : Dave S. B. Hoon
language : en
Publisher:
Release Date : 2004

Circulating Nucleic Acids In Plasma Serum Iii And Serum Proteomics written by Dave S. B. Hoon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.

Numerous questions remain regarding the origin, release, clearance, clinical utility, and possible functionality of circulating nucleic acids. Serum proteomics is introduced as a new topic to CNAPS and is expected to provide yet another platform for breakthrough discoveries. Serum proteomics topics will address both cancer and early pregnancy.

Circulating Nucleic Acids In Plasma Or Serum Ii

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Author : Y. M. Dennis Lo
language : en
Publisher:
Release Date : 2001-01-01

Circulating Nucleic Acids In Plasma Or Serum Ii written by Y. M. Dennis Lo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-01 with Science categories.

Biological and diagnostic aspects of circulating nucleic acids are explored in this collection of work from a recent symposium. Contributions are arranged in sections on tumor DNA in plasma and serum, viral DNA as a tumor marker, other approaches for cancer detection, fetal DNA and cells in maternal