Classifying Noisy Protein Sequence Data A Case Study Of Immunoglobulin Light Chains
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Classifying Noisy Protein Sequence Data A Case Study Of Immunoglobulin Light Chains
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Author :
language : en
Publisher:
Release Date : 2005
Classifying Noisy Protein Sequence Data A Case Study Of Immunoglobulin Light Chains written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
The classification of protein sequences obtained from patients with various immunoglobulin-related conformational diseases may provide insight into structural correlates of pathogenicity. However, clinical data are very sparse and, in the case of antibody-related proteins, the collected sequences have large variability with only a small subset of variations relevant to the protein pathogenicity (function). On this basis, these sequences represent a model system for development of strategies to recognize the small subset of function-determining variations among the much larger number of primary structure diversifications introduced during evolution. Under such conditions, most protein classification algorithms have limited accuracy. To address this problem, we propose a support vector machine (SVM)-based classifier that combines sequence and 3D structural averaging information. Each amino acid in the sequence is represented by a set of six physicochemical properties: hydrophobicity, hydrophilicity volume, surface area, bulkiness and refractivity. Each position in the sequence is described by the properties of the amino acid at that position and the properties of its neighbors in 3D space or in the sequence. A structure template is selected to determine neighbors in 3D space and a window size is used to determine the neighbors in the sequence. The test data consist of 209 proteins of human antibody immunoglobulin light chains, each represented by aligned sequences of 120 amino acids. The methodology is applied to the classification of protein sequences collected from patients with and without amyloidosis, and indicates that the proposed modified classifiers are more robust to sequence variability than standard SVM classifiers, improving classification error between 5 and 25% and sensitivity between 9 and 17%. The classification results might also suggest possible mechanisms for the propensity of immunoglobulin light chains to amyloid formation.
Pattern Recognition And Machine Vision
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Author : Patrick Shen-Pei Wang
language : en
Publisher: River Publishers
Release Date : 2010
Pattern Recognition And Machine Vision written by Patrick Shen-Pei Wang and has been published by River Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Computers categories.
In recent years, there has been a growing interest in the fields of pattern recognition and machine vision in academia and industries. New theories have been developed with new technology and systems designs in both hardware and software. They are widely applied to our daily life to solve real problems in diverse areas such as science, engineering, agriculture, e-commerce, education, robotics, government, medicine, games and animation, medical imaging analysis and diagnosis, military, and national security. The foundation of this field can be traced back to the late Prof. King-Sun Fu, one of the founding fathers of pattern recognition, who, with visionary insight, founded the International Association for Pattern Recognition in 1978. Almost 30 years later, the world has witnessed this field's rapid growth and development. It is probably true to say that most people are affected by or use applications of pattern recognition in daily life. Today, on the eve of 25th anniversary of the unfortunate and untimely passing of Prof. Fu, we are proud to produce this collection works from world renowned professionals and experts in pattern recognition and machine vision in honor and memory of the late Prof. King-Sun Fu. We hope this book will help further promote not only fundamental principles, systems, and technologies but also the vast range of applications that help in solving problems in daily life.
Kernel Methods In Bioengineering Signal And Image Processing
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Author : Gustavo Camps-Valls
language : en
Publisher: IGI Global
Release Date : 2007-01-01
Kernel Methods In Bioengineering Signal And Image Processing written by Gustavo Camps-Valls and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-01 with Technology & Engineering categories.
"This book presents an extensive introduction to the field of kernel methods and real world applications. The book is organized in four parts: the first is an introductory chapter providing a framework of kernel methods; the others address Bioegineering, Signal Processing and Communications and Image Processing"--Provided by publisher.
Medical Informatics Concepts Methodologies Tools And Applications
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Author : Tan, Joseph
language : en
Publisher: IGI Global
Release Date : 2008-09-30
Medical Informatics Concepts Methodologies Tools And Applications written by Tan, Joseph and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-30 with Education categories.
Provides a collection of medical IT research in topics such as clinical knowledge management, medical informatics, mobile health and service delivery, and gene expression.
The Immunoglobulin Factsbook
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Author : Marie-Paule Lefranc
language : en
Publisher: Academic Press
Release Date : 2001-05-23
The Immunoglobulin Factsbook written by Marie-Paule Lefranc and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-05-23 with Medical categories.
The FactsBook series has established itself as the best source of easily accessible and accurate facts about protein groups. Books in the series use an easy-to-follow format and are meticulously researched and compiled by experts in the field.The Immunoglobulin FactsBook is the first published reference for all 203 human functional and ORF immunoglobulin genes. It is complete and standardized and employs nomenclature approved by the HUGO Nomenclature Committee.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1999
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medicine categories.
Clinical Case Studies For The Family Nurse Practitioner
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Author : Leslie Neal-Boylan
language : en
Publisher: John Wiley & Sons
Release Date : 2011-11-28
Clinical Case Studies For The Family Nurse Practitioner written by Leslie Neal-Boylan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-28 with Medical categories.
Clinical Case Studies for the Family Nurse Practitioner is a key resource for advanced practice nurses and graduate students seeking to test their skills in assessing, diagnosing, and managing cases in family and primary care. Composed of more than 70 cases ranging from common to unique, the book compiles years of experience from experts in the field. It is organized chronologically, presenting cases from neonatal to geriatric care in a standard approach built on the SOAP format. This includes differential diagnosis and a series of critical thinking questions ideal for self-assessment or classroom use.
Withrow And Macewen S Small Animal Clinical Oncology
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Author : Stephen J. Withrow
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-11-13
Withrow And Macewen S Small Animal Clinical Oncology written by Stephen J. Withrow and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-13 with Medical categories.
With a unique focus on the most effective interventional techniques, Withrow & MacEwen's Small Animal Clinical Oncology, 5th Edition tells the full story of cancer in dogs and cats - what it is, how to diagnose it, and how to treat many of the most common cancers encountered in clinical practice. Nearly 500 color photographs, diagrams, x-rays, and gross views depict the clinical manifestations of various cancers. This edition covers the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. With contributions from 65 veterinary oncology experts, this authoritative reference is a must-have for current, evidence-based therapeutic strategies on canine and feline oncology. "I really love this book. If you are interested in veterinary oncology, have a flick through this book online or at a conference when you get the chance. I hope that you agree with me that this is the definitive oncology reference source for the early 21st century and that you feel compelled to buy it. Your patients will thank you for it." Reviewed by: Gerry Polton MA VetMB MSc(Clin Onc) DipECVIM-CA(Onc) MRCVS, UK Date: July 2014 Cutting-edge information on the complications of cancer, pain management, and the latest treatment modalities prepares you to diagnose and treat pets with cancer rather than refer cases to a specialist. A consistent format for chapters on body system tumors includes coverage of incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies. A systems approach to the diagnosis and management of cancer facilitates access to information about the many malignancies affecting small animal patients. Nearly 500 color images provide accurate depictions of specific diseases and procedures. Helpful drug formularies provide quick access to information on indications, toxicities, and recommended dosages for chemotherapeutic and analgesic drugs used in cancer treatment. Expert contributors provide in-depth coverage of the most current information in his or her respective specialty in veterinary oncology. Chemotherapy protocols are included when case studies prove clinical efficacy. Discussion of compassion and supportive care for the management of pain, nutritional needs, and grief includes methods for handling the pet's pain and nutritional complications as well as the pet owner's grief when treatment is not successful. Thoroughly UPDATED chapters cover the most recent changes in the clinical management of melanoma, mast cell tumors, tumors of the skeletal system, tumors of the endocrine system, tumors of the mammary gland, urinary cancers, nervous system cancers, lymphoma, and histiocytic diseases. NEW Clinical Trials and Developmental Therapeutics chapter discusses the various phases of clinical trials as well as current challenges and opportunities in oncology drug development. NEW! A focus on the best recommended treatment options highlights therapeutic strategies that have been vetted by veterinary oncology experts. NEW co-author Dr. Rodney L. Page adds his valuable perspective, expertise, and research experience.
Computational Protein Design
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Author : Ilan Samish
language : en
Publisher: Humana
Release Date : 2016-12-03
Computational Protein Design written by Ilan Samish and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-03 with Science categories.
The aim this volume is to present the methods, challenges, software, and applications of this widespread and yet still evolving and maturing field. Computational Protein Design, the first book with this title, guides readers through computational protein design approaches, software and tailored solutions to specific case-study targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Protein Design aims to ensure successful results in the further study of this vital field.
Molecular Evolution
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Author : Roderick D.M. Page
language : en
Publisher: John Wiley & Sons
Release Date : 2009-07-14
Molecular Evolution written by Roderick D.M. Page and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-14 with Science categories.
The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility.