Clinical Bone Marrow And Blood Stem Cell Transplantation
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Clinical Bone Marrow And Blood Stem Cell Transplantation
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Author : Kerry Atkinson
language : en
Publisher: Cambridge University Press
Release Date : 2004
Clinical Bone Marrow And Blood Stem Cell Transplantation written by Kerry Atkinson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
Drs Richard Champlin, Jerome Ritz, Willem Fibbe, Per Ljungman, and Malcom K. Brenner join Kerry Atkinson as editors of this definitive reference on the clinical practice and underlying science of hematopoietic stem cell transplantation. This third edition text is significantly revised and updated with 124 chapters balancing scientific explanations with practical information on patient care for all aspects of autologous, syngeneic, and allogeneic transplantation. This edition includes 18 new chapters on significant topics such as plasticity of stem cells, embryonic stem cells, and nonmyeloablative conditioning regimens. Thoroughly referenced through 2003, the chapters are divided into 15 sections, including biological background and practical procedures, clinical results, transplant-related and organ-specific complications, laboratory aspects, and developing areas, with a final 'breaking news' chapter from this rapidly evolving field. Over 170 internationally-recognized experts contributed to this authoritative and practical text that is an essential resource for hematologists, oncologists, and transplant specialists.
Clinical Manual Of Blood And Bone Marrow Transplantation
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Author : Syed A. Abutalib
language : en
Publisher: John Wiley & Sons
Release Date : 2017-06-12
Clinical Manual Of Blood And Bone Marrow Transplantation written by Syed A. Abutalib and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-12 with Medical categories.
Providing the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questions Covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program Contains concise chapters written with a focus on tables, algorithms and figures to aid rapid referral Benefits from expert contributions from an international authorship
The Bmt Data Book
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Author : Kerry Atkinson
language : en
Publisher: Cambridge University Press
Release Date : 1998
The Bmt Data Book written by Kerry Atkinson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
The BMT Data Book provides a unique reference tool for all clinicians involved in bone marrow or blood cell transplantation.
Hematopoietic Stem Cell Transplantation In Clinical Practice
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Author : Jennifer G. Treleaven
language : en
Publisher: Elsevier Health Sciences
Release Date : 2008-09-02
Hematopoietic Stem Cell Transplantation In Clinical Practice written by Jennifer G. Treleaven and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-02 with Medical categories.
A guide to the practice of stem cell transplantation, its status in the treatment of various disorders and the problems that arise after transplantation, aimed at the whole transplant team. An up to date guide to best practice in the use of stem cell transplantation, covering current status in the treatment of malignant and non-malignant conditions, practical aspects and problems such as infection and graft versus host disease. Has a practical, accessible approach with free use of algorithms, list tables. Aimed at the whole transplant team - this is an interdisciplinary field. International contributor team with editors in the UK and USA. Illustrated in colour throughout.
Blood Stem Cell Transplantation
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Author : Jane N. Winter
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Blood Stem Cell Transplantation written by Jane N. Winter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Blood Stem Cell Transplantation conveys the excitement that accompanies the newest developments in hematopoietic stem cell transplantation. Some of the applications that stand to impact this field most significantly are based on recent advances in the biological sciences, as demonstrated by the chapters on gene therapy, on the detection of minimal residual disease using molecular techniques, and on the use of radioimmunoconjugates targeting lymphoma and leukemia-associated antigens. Others are the results of clinical observations - e.g., the association between graft-versus-host- disease (GVHD) and durable remissions that have led to creative clinical experiments such as donor leukocyte infusions (DLI). Attempts to unravel the biological events that underlie the responses seen in patients with relapsed chronic myelogenous leukemia treated with DLI are likely to provide the basis for future refinements in this clinical approach. Hopefully, improved response rates and reduced toxicity will result. The power of the immunologic response in controlling malignant disease is underscored in the chapter on post-transplant immunotherapy. The complex immunologic process that results in clinical GVHD may be dissected and engineered to provide clinical benefits that include, in addition to its antineoplastic effects, the amelioration of its clinical manifestations. Better control of GVHD with less global immunosuppression will facilitate the use of mismatched and unrelated donors. This area of investigation perfectly illustrates the continued interplay between the laboratory and the clinic. The continued cross-fertilization of ideas between immunologists, molecular biologists and clinical investigators is likely to yield important advances in this field for years to come. Possible applications of stem cell transplantation continue to grow with the identification of alternative sources of stem cells and the potential to engineer and/or expand the graft. Although the use of unrelated and mismatched donors continues to increase, the possibilities associated with umbilical cord blood transplantation are legion, especially if stem cells can be expanded ex vivo to provide grafts for full-sized adults. Using techniques in which contaminating malignant cells may be eliminated from autografts through positive selection, autologous transplantation may prove highly effective, especially when coupled with post-transplant immunotherapy. Some of these same methodologies have helped facilitate the use of autologous grafts for transplantation in patients with chronic myelogenous leukemia without allogeneic donors. Advances in the supportive care of transplant patients, including the pretransplant identification of those at risk from pulmonary complications and the use of cytokines to speed engraftment, have reduced morbidity and mortality to such a degree that it is appropriate to consider high-dose therapy and stem cell reconstitution in patients with nonmalignant diseases. The impressive advances that have occurred in transplantation for thalassemia are described by pioneers in their area of investigation. The burgeoning field of transplantation for autoimmune disorders, including its immunobiologic basis and soon-to- be-realized clinical potential, is also summarized. Continued progress in the use of high-dose therapy with stem cell rescue for the treatment of pediatric tumors, which derives in part from improved supportive care, is detailed. The sobering voice of the health care economists underscores the necessary limitations to our seemingly unbridled imagination. Cost- consciousness and financial know-how will need to be reflected in future study designs. Given the seemingly endless applications of our technology, strategies to insure its cost-effectiveness will be necessary. Continued financial support for laboratory investigation and for the clinical experiments they generate will be required if we are to go forward. Blood Stem Cell Transplantation lays the foundation for many of these future advances; it is incumbent upon us all to insure its realization.
Pediatric Stem Cell Transplantation
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Author : Paulette Mehta
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2004
Pediatric Stem Cell Transplantation written by Paulette Mehta and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Bone marrow categories.
This textbook examines stem cell transplatation in pediatric patients.
Current Controversies In Bone Marrow Transplantation
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Author : Brian J. Bolwell
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-12-02
Current Controversies In Bone Marrow Transplantation written by Brian J. Bolwell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-02 with Medical categories.
Leading transplant physicians critically review and interpret twenty-one key clinical challenges in bone marrow/hematopoietic cell transplantation, and offer their best personal recommendations for treatment. Topics range from transplant strategies to complications of bone marrow transplantation, including a discussion of the indications, benefits, and the risks for a variety of leukemias, lymphomas, and solid tumors. The authors debate such contentious issues as the appropriateness of transplants in older patients, how many stem cells are sufficient for engraftment, and the pros and cons of umbilical cord blood transplantation. Up-to-date and clinically focused, Current Controversies in Bone Marrow Transplantation offers clinical oncologists, hematology/oncology fellows in training, and residents in internal medicine today's best ready reference and management guide for all their critical oncologic problems arising from the use of bone marrow/stem cell transplantation.
Autologous Stem Cell Transplantation
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Author : Angelo Carella
language : en
Publisher: Routledge
Release Date : 2020-08-26
Autologous Stem Cell Transplantation written by Angelo Carella and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Medical categories.
This textbook integrates basic research and clinical aspects underlying the most recent results in those malignant diseases where progress is most effective. Recent evidence shows that higher doses are better in inducing higher cure rates in hematological neoplasias, although myeloblation related to dose intensity can be a limiting factor. The toxicity can now be controlled with autologous marrow and peripheral blood progenitor cell transplantation, used with or without growth factors. The combination of high dose chemoradiotherapy followed by re-infusion of autologous stem cells constitute a dramatic advance in the treatment of refactory and relapse hematological neoplasias.
Stem Cell Transplantation For Hematologic Malignancies
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Author : Robert J. Soiffer
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-01-29
Stem Cell Transplantation For Hematologic Malignancies written by Robert J. Soiffer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-29 with Medical categories.
A comprehensive survey of the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation.
Hematopoietic Stem Cell Transplantation Research Advances
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Author : Karl B. Neumann
language : en
Publisher: Nova Publishers
Release Date : 2008
Hematopoietic Stem Cell Transplantation Research Advances written by Karl B. Neumann and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Hematopoietic stem cells categories.
Hematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (that is, bone marrow transplantation) or blood. Stem cell transplantation is a medical procedure in the fields of haematology and oncology, most often performed for people with diseases of the blood, bone marrow, or certain types of cancer. Stem cell transplantation was pioneered using bone-marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognised with a Nobel Prize in Physiology and Medicine. Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells. His work also reduced the likelihood of developing a life-threatening complication called Graft-versus-host disease. With the availability of the stem cell growth factors GM-CSF and G-CSF, most hematopoeitic stem cell transplantation procedures are now performed using stem cells collected from the peripheral blood, rather than from the bone marrow. Collecting stem cells provides a bigger graft, and does not require that the donor be subjected to general anaesthesia to collect the graft. Hematopoeitic stem cell transplantation remains a risky procedure with many possible complications; it has always been reserved for patients with life-threatening diseases. This book presents recent leading research in the field.