Clozapine
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Clozapine
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Author : Vladimir Lerner
language : en
Publisher:
Release Date : 2020-04-21
Clozapine written by Vladimir Lerner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-21 with categories.
Even though clozapine is the only drug with evidence-based efficacy in schizophrenia symptoms not responding to other agents, it is still under-prescribed in most countries around the world. The barriers for initiating clozapine are evident in both clinicians and patients. Prescribers mainly report delaying clozapine because of fear of severe side effects and lack of knowledge regarding management of side effects driven by stigmatic rather evidence-based views. Patients report reservations toward the need for safety regulation and blood tests. Enduring psychotic illness is often associated with high level of burden of symptoms, which does not allow progress into recovery process in the community. It is often the case that treatment with clozapine has a dramatic effect on symptoms, otherwise refractory. However, there cases in which there is only minor or no effect of the drug. In these cases, sometimes referred to as ultra-resistant schizophrenia, it is advised to optimise clozapine treatment using pharmacokinetic considerations and confirm sufficient clozapine serum levels using therapeutic drug monitoring. Further steps include precise diagnosis and management of other physical or psychiatric comorbidities, offering targeted psychotherapy such as CBT and family interventions and eventually to wait, as sometimes there are cases of late response. In this book we aimed at providing clinicians with practical, up-do-date knowledge to support their decision-making and safety management when prescribing clozapine. It is our hope that using the information in this book would encourage both prescribers and patients to consider clozapine treatment when it is needed, in a timely fashion. We believe that accurate and systematic information is a key for reducing anxiety and relieving stigma associated with clozapine treatment.
The Clozapine Clinic
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Author : Julia Brown
language : en
Publisher: Routledge
Release Date : 2022-04-25
The Clozapine Clinic written by Julia Brown and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-25 with Psychology categories.
This book is the first ethnography of the little-known world of clozapine clinics in Australia and the United Kingdom. Anthropologist Julia Brown engages with the narratives of people living in extreme health circumstances to challenge some of the assumptions made about clozapine treatment and to explore what it means to be diagnosed with ‘treatment-resistant schizophrenia.’ Clozapine is a gold standard but controversial treatment for psychosis that requires lifelong monitoring to reduce fatality caused by clozapine side effects. Focusing on the social world of the clozapine clinic and based on the author’s own extensive research, this book explores what it means to live with the interpersonal challenges of psychosis and trauma, the risks of multi-morbidity, and how clozapine clients can experience meaningful control over their health. Brown uses her findings to point to the practical clinical implications of clozapine clients being given more recognition and accountability, and to explore how health agency relates to moral agency. The Clozapine Clinic particularly highlights the importance of investing in continuity of healthcare and is an essential read for caregivers who work with sufferers of psychosis as well as academics and policymakers focused on mental health.
The Clozapine Handbook
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Author : Jonathan M. Meyer
language : en
Publisher: Cambridge University Press
Release Date : 2019-05-16
The Clozapine Handbook written by Jonathan M. Meyer and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-16 with Medical categories.
A practical Handbook that provides clinically-focussed approaches and guidelines on the effective management of clozapine treated patients.
Clozapine Therapy
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Author : Sics Editore
language : en
Publisher: SICS Editore
Release Date : 2014-10-01
Clozapine Therapy written by Sics Editore and has been published by SICS Editore this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-01 with Medical categories.
Clozapine is an antipsychotic agent that has proved to be effective in treatment-resistant schizophrenia. Its use is reserved for patients unresponsive to other medication or intolerant of alternatives due to their adverse effects . It may also be prescribed for psychosis associated with Parkinson’s disease where conventional treatment has failed. In treatment-resistant schizophrenia, clozapine should only be prescribed by physicians well versed in the use of clozapine therapy in psychiatric illness or by psychiatrists. In psychosis associated with Parkinson's disease, clozapine may also be prescribed by a neurologist. When treated with clozapine many schizophrenic patients can be managed in the community. Primary care physicians should therefore be familiar with the principles of monitoring clozapine therapy (frequent laboratory testing, recognition of adverse effects).
Clozapine In Treatment Resistant Schizophrenia
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Author : Yvon Lapierre
language : en
Publisher:
Release Date : 1992
Clozapine In Treatment Resistant Schizophrenia written by Yvon Lapierre and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Antipsychotic drugs categories.
Clozapine Leponex Clozaril
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Author :
language : en
Publisher:
Release Date : 1989
Clozapine Leponex Clozaril written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with categories.
The Clozapine Clinic
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Author : Julia E. H. Brown
language : en
Publisher:
Release Date : 2022
The Clozapine Clinic written by Julia E. H. Brown and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Clozapine categories.
"This book is the first ethnography of the little-known world of clozapine clinics in Australia and the United Kingdom. Anthropologist Julia Brown challenges some of the assumptions made about clozapine treatment and explores what it means to be diagnosed with 'treatment-resistant schizophrenia'"--
Clozapine
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Author :
language : en
Publisher:
Release Date : 1992
Clozapine written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Antidepressants categories.
Clozapine And Its Safety In Clinical Practice
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Author : Kateu0159ina Horsku00e1
language : en
Publisher:
Release Date : 2017
Clozapine And Its Safety In Clinical Practice written by Kateu0159ina Horsku00e1 and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Introduction: Clozapine represents an irreplaceable therapeutic strategy, particularly in treatment-resistant schizophrenia (TRS) therapy, which, however, carries certain risk.Objects: The aim of the study was to evaluate frequency of clozapine adverse effects in patients with schizophrenia-spectrum disorders hospitalized at Department of Psychiatry, University Hospital Brno, during the period 2012-2014.Methods: Data were evaluated retrospectively, out of total number of 336 patients (285 patients with F200, F231, F232, and 51 patients with F25), 62 patients (41 men and 21 women) were treated by clozapine. Results: Clozapine doses ranged from 100-700 mg/day in men, 150-600 mg/day in women, mean dose was approx. 300 mg/day. Adverse effects of clozapine included tachycardia (50 %), constipation (34 %), increased weight (15 %), tiredness and blood dyscrasia, manifested as neutropenia in four patients, none presented agranulocytosis. With lower frequencies were noted hypertension, salivation, insomnia.Conclusion: Although a relatively wide spectrum of adverse events has been reported with high frequency, none of the adverse events led to clozapine discontinuation or was classified as severe. The benefits of clozapine therapy undoubtedly outweigh the risks which can be reduced by close monitoring and adequate interventions combined with therapeutic strategies u2013 e.g. betablockers for tachycardia, dietary interventions, laxatives for constipation and dietary measures for metabolic side effects together with pharmacotherapy of dyslipidemia, pre T diabetes/diabetes or obesity. The most serious risk of clozapine therapy is agranulocytosis, occurring with prevalence of 1-2 %, regular blood screening as recommended and early therapy can prevent cases of this life-threatening condition and eliminate the risk.
Meta Analysis Of The Cost Effectiveness Of Clozapine
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Author : Christine M. Jean-Jacques
language : en
Publisher:
Release Date : 2003
Meta Analysis Of The Cost Effectiveness Of Clozapine written by Christine M. Jean-Jacques and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Antipsychotic drugs categories.