Cognitive Deficits In Schizophrenia And Other Neuropsychiatric Disorders Convergence Of Preclinical And Clinical Evidence
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Cognitive Deficits In Schizophrenia And Other Neuropsychiatric Disorders Convergence Of Preclinical And Clinical Evidence
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Author : Ales Stuchlik
language : en
Publisher: Frontiers Media SA
Release Date : 2015-10-23
Cognitive Deficits In Schizophrenia And Other Neuropsychiatric Disorders Convergence Of Preclinical And Clinical Evidence written by Ales Stuchlik and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-23 with Electronic book categories.
Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such deficits significantly disrupt quality of life and daily functioning of patients. Cognitive deficits in neuropsychiatric diseases are associated with alterations of brain morphology and function, and are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, i.e. measurable phenotypes linking these disaeses with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Animal models may not mimic the full spectrum of clinical symptoms, but may act as analogies of particular behaviors or other pathological outcomes. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, several behavioral tests to measure cognitive performance in rodents and other species have been implemented. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of neuropsychiatric disorders, such as schizophrenia. This Research Topic also delineates future directions for translational studies aimed at developing novel treatments/interventions of cognitive disturbances.
Cannabis
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Author : Marco Colizzi
language : en
Publisher: MDPI
Release Date : 2021-02-05
Cannabis written by Marco Colizzi and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-05 with Science categories.
Over the years, there has been increasing interest into the public health impact of cannabis use, especially by young adults. This follows the evidence of a growing prevalence of regular cannabis use worldwide, with approximately 200 million users. Recreational cannabis use, especially a frequent use of products with high levels of its main psychoactive ingredient delta-9-tetrahydrocannabinol (Δ 9-THC), can cause dependence and have transient and long-lasting detrimental mental health effects, also negatively impacting cognitive processing and brain function and metabolism. In regular users, the development of tolerance to some of the effects of cannabis, especially the pleasurable ones, may lead to progressively heavier use in order to obtain the same effects in terms of their intensity, with higher health risks. However, the Cannabis Sativa plant contains different chemicals with different potential effects. In this regard, cannabidiol has gained interest because of its potential therapeutic properties, in line with evidence that CBD and Δ9-THC may exhibit opposite effects at the cannabinoid receptor type 1 (CB1), Δ9-THC being a partial agonist and CBD an antagonist/inverse agonist. Different cannabinoids may modulate human brain function and behavior in different ways, with different risk–benefit profiles.
The Role Of Immediate Early Genes In Neuropsychiatric Illness
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Author : Amelia L. Gallitano
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-30
The Role Of Immediate Early Genes In Neuropsychiatric Illness written by Amelia L. Gallitano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-30 with categories.
The Adenosine Receptors
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Author : Pier Andrea Borea
language : en
Publisher: Humana Press
Release Date : 2018-07-28
The Adenosine Receptors written by Pier Andrea Borea and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-28 with Medical categories.
This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.
Clinical Staging In Psychiatry
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Author : Patrick D. McGorry
language : en
Publisher: Cambridge University Press
Release Date : 2019-08-29
Clinical Staging In Psychiatry written by Patrick D. McGorry and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-29 with Medical categories.
Clinical staging is a solution to transform psychiatric diagnosis and improve mental health outcomes.
Cognition In Schizophrenia
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Author : Tonmoy Sharma
language : en
Publisher:
Release Date : 2000
Cognition In Schizophrenia written by Tonmoy Sharma and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
Although it has been known for 100 years that cognitive functioning is impaired in schizophrenia, the implications of this impairment have only recently been clearly understood. While in the past, cognitive deficits were thought to be the result of other aspects of the illness, such as poor co-operation, or as a result of the treatment of the illness, it is now known that these factors exert only a very minor influence on cognitive deficit. This book, with contributions from the major international names in the field, reviews the most recent research on the impairment of cognitive functioning in schizophrenia, covering: what it is, how wide-ranging it can be, what the clinical implications are, and how it can be treated? A detailed insight into cognitive deficit is the key to understanding why previous treatments have failed, and the key by which new treatments may change this terrible illness, treatments significantly more effective than earlier interventions.
Cognitive Impairment In Schizophrenia
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Author : Philip D. Harvey
language : en
Publisher: Cambridge University Press
Release Date : 2013-01-24
Cognitive Impairment In Schizophrenia written by Philip D. Harvey and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-24 with Medical categories.
Provides state-of-the-art information about cognition in schizophrenia with a wide ranging focus on measuring and treating cognitive deficits.
Serotoninergic Neurons And 5 Ht Receptors In The Cns
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Author : H.G. Baumgarten
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Serotoninergic Neurons And 5 Ht Receptors In The Cns written by H.G. Baumgarten and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
With contributions by numerous experts
Secondary Schizophrenia
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Author : Perminder S. Sachdev
language : en
Publisher: Cambridge University Press
Release Date : 2010-02-04
Secondary Schizophrenia written by Perminder S. Sachdev and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-04 with Medical categories.
Schizophrenia may not be a single disease, but the result of a diverse set of related conditions. Modern neuroscience is beginning to reveal some of the genetic and environmental underpinnings of schizophrenia; however, an approach less well travelled is to examine the medical disorders that produce symptoms resembling schizophrenia. This book is the first major attempt to bring together the diseases that produce what has been termed 'secondary schizophrenia'. International experts from diverse backgrounds ask the questions: does this medical disorder, or drug, or condition cause psychosis? If yes, does it resemble schizophrenia? What mechanisms form the basis of this relationship? What implications does this understanding have for aetiology and treatment? The answers are a feast for clinicians and researchers of psychosis and schizophrenia. They mark the next step in trying to meet the most important challenge to modern neuroscience – understanding and conquering this most mysterious of human diseases.
Proteomics And Metabolomics In Psychiatry
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Author : D. Martins-de-Souza
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2014-05-23
Proteomics And Metabolomics In Psychiatry written by D. Martins-de-Souza and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-23 with Science categories.
This publication compiles data generated by proteomics and metabolomics about psychiatric disorders. Leading researchers in these fields review the basic principles of proteomics and metabolomics and propose the new directions to be followed in molecular psychiatry. The chapters divided into two sections – Schizophrenia/Psychotic Disorders and Mood Disorders – deal with findings in diverse tissues from human and preclinical models in order to unravel the biology and biochemistry behind the establishment and course of these illnesses as well as potential biomarkers for clinical applications. More than an update, this publication indicates the next steps to discover biomarkers and understand psychiatric disorders more comprehensively. This publication is valuable reading for psychiatrists, neuroscientists and analytical chemists interested in the basics of proteomics and metabolomics, psychiatric definitions and the most advanced hypotheses about the pathobiology of schizophrenia, depression and bipolar disorder.