Combinatorial Approaches To Enhance Anti Tumor Immunity Focus On Immune Checkpoint Blockade Therapy
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Combinatorial Approaches To Enhance Anti Tumor Immunity Focus On Immune Checkpoint Blockade Therapy
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Author : Patrik Andersson
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-27
Combinatorial Approaches To Enhance Anti Tumor Immunity Focus On Immune Checkpoint Blockade Therapy written by Patrik Andersson and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-27 with categories.
The immune system harbors great potential for controlling and eliminating tumors. Recent developments in the field of immuno-oncology has led to unprecedented clinical benefits for a broad spectrum of solid tumors. However, immunotherapy (IT) approaches currently have several limitations including (i) low response rate; (ii) development of resistance and (iii) causing severe immune-related adverse effects (IrAEs), which underline the importance of adequate patient selection. Importantly, IT holds promising synergistic potential when combined with standard-of-care chemotherapy, radiotherapy (RT) and anti-angiogenic therapy (AAT) as part of multi-modal oncologic treatment regimes. Published data suggest that there are potential synergy between RT and AAT, which ultimately could help potentiate the response to IT. However, the complex interactions between RT and IT and/or AAT remain poorly understood. Many research questions including optimal timing, scheduling and dosing, as well as patient selection and side effects of combined therapy approaches, remain to be addressed. This Research Topic aims to give a comprehensive overview of the current field with particular emphasis on the future outlook of RT and AAT as complementary approaches to improve IT in solid tumors.
Drug Repurposing
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Author : Farid A. Badria
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-12-02
Drug Repurposing written by Farid A. Badria and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-02 with Medical categories.
Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.
Cancer Immunology And Immunotherapy
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Author : Mansoor M. Amiji
language : en
Publisher: Elsevier
Release Date : 2021-08-27
Cancer Immunology And Immunotherapy written by Mansoor M. Amiji and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-27 with Business & Economics categories.
Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO
Tumor Ablation And Immunity
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Author : Yueyong Xiao
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-29
Tumor Ablation And Immunity written by Yueyong Xiao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-29 with Medical categories.
Immunotherapy As An Evolving Approach For The Treatment Of Breast Cancer
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Author : Mai F. Tolba
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-13
Immunotherapy As An Evolving Approach For The Treatment Of Breast Cancer written by Mai F. Tolba and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-13 with Medical categories.
The Therapeutic Potential Of Antigen Presenting Cells
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Author : Georgina Clark
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-16
The Therapeutic Potential Of Antigen Presenting Cells written by Georgina Clark and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-16 with Medical categories.
Computational Genomics And Structural Bioinformatics In Personalized Medicines
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Author : George Priya Doss C
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-26
Computational Genomics And Structural Bioinformatics In Personalized Medicines written by George Priya Doss C and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-26 with Medical categories.
Harnessing Oncolytic Virus Mediated Antitumor Immunity
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Author : Philippe Fournier
language : en
Publisher: Frontiers Media SA
Release Date : 2015-03-02
Harnessing Oncolytic Virus Mediated Antitumor Immunity written by Philippe Fournier and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-02 with Cancer categories.
Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity.
Novel Anti Cancer Agents Targeting Tumour Metastasis And Stemness
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Author : Bo Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-11-12
Novel Anti Cancer Agents Targeting Tumour Metastasis And Stemness written by Bo Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-12 with Science categories.
Cancer metastasis is the leading cause of cancer-related deaths. Despite the development of anti-cancer drugs over nearly a century, the 5-year survival rate for patients with metastatic cancer, especially those with distal metastases, remains low. Cancer stem cells (CSCs), also known as cancer-initiating cells, refer to a small population of cells in cancerous tissue with unlimited proliferative potential, capable of reconstituting tumorigenesis. CSCs maintain a relatively stable proportion in cancer tissues through self-renewal and differentiation and are likely to tolerate radiotherapy and chemotherapy drugs. When exposed to certain stimulating factors, CSCs rapidly proliferate, leading to drug resistance and cancer recurrence. Importantly, CSCs can be transferred to distant sites through epithelial-to-mesenchymal transition (EMT) and immune escape, resulting in cancer metastasis. Thus, CSCs constitute underlying factors in tumorigenesis, drug resistance, recurrence, and metastasis, making them potential intervention points for the development of anti-cancer therapeutic strategies.
Precision Cancer Therapies Immunologic Approaches For The Treatment Of Lymphoid Malignancies
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Author : Owen A. O'Connor
language : en
Publisher: John Wiley & Sons
Release Date : 2024-02-21
Precision Cancer Therapies Immunologic Approaches For The Treatment Of Lymphoid Malignancies written by Owen A. O'Connor and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-21 with Medical categories.
Presents timely and authoritative information on the development of precision cancer therapies as applied to hematologic malignancies The Precision Cancer Therapies series focuses on how to understand and translate fundamental basic science into information that can be directly applied to patients to advance care. Each volume of the series integrates the relevant biological concepts and principles necessary for translating this science to practitioners of this science. Precision Cancer Therapies, Volume Two, focuses on sophisticated immunotherapies targeting cancers affecting the blood, bone marrow, and lymph nodes. Edited and authored by the foremost authorities in the field, this comprehensive reference text covers targeting of cell surface receptors, antibody-drug conjugates (ADC), targeting immune checkpoint, targeting macrophages, EBV-directed immunotherapies, tumor-associated antigens (TAA), and chimeric antigen receptor T-cells (CAR-T). Divided into nine sections, Volume Two includes an overview of the history of immunotherapy development in cancer, as well as a concluding section addressing the mechanistic basis and role of immunomodulatory drugs, analytical tools to quantitate immune-mediated effects, and other topics in immunotherapy. Chapters on specific therapeutics or therapeutic classes include a basic explanation of the underlying pathway and target, the pharmacology of the drug/class, relevant preclinical and clinical data, and discussion of clinical management and potential predictive biomarkers of response. This book also: Delivers a definitive, state-of-the-art review of the relevant biology and its importance in the broader context of cancer biology Focuses on agents that mediate cell killing in lymphoma through a variety of immunologic mechanisms Covers FDA-approved drugs and their indications, as well as drugs currently in development Provides information on monotherapy and combination therapy, summary tables of trials, and discussion of toxicity and efficacy Includes boxed sections highlighting major unique points about the information in the chapter Precision Cancer Therapies, Volume Two: Immunologic Approaches for the Treatment of Lymphoid Malignancies, From Concept to Practice is an indispensable resource for medical, scientific, and allied medical professionals, advanced students, and interested general readers with background knowledge in the subject.