Combinatorial Chemistry On Solid Supports
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Combinatorial Chemistry On Solid Supports
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Author : Stefan Braese
language : en
Publisher: Springer
Release Date : 2007-06-23
Combinatorial Chemistry On Solid Supports written by Stefan Braese and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-23 with Science categories.
With contributions by numerous experts
Solid Supported Combinatorial And Parallel Synthesis Of Small Molecular Weight Compound Libraries
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Author : D. Obrecht
language : en
Publisher: Elsevier
Release Date : 1998-10-16
Solid Supported Combinatorial And Parallel Synthesis Of Small Molecular Weight Compound Libraries written by D. Obrecht and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-10-16 with Science categories.
This book gives an overview of the current state of the art of combinatorial organic synthesis. While the main focus is on multicomponent and multigeneration strategies using polymeric supports, there is also a Chapter on solution strategies using polymer-grafted reagents which allow minimisation of work-up procedures. Some of the most important strategies and tools are presented and summarised, with an explanation of the pivotal role of organic synthesis in the creation of diversity.
Combinatorial Chemistry
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Author : Stephen R. Wilson
language : en
Publisher: John Wiley & Sons
Release Date : 1997-03-28
Combinatorial Chemistry written by Stephen R. Wilson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-03-28 with Medical categories.
The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.
Combinatorial Chemistry
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Author : Nicholas K. Terrett
language : en
Publisher:
Release Date : 1998
Combinatorial Chemistry written by Nicholas K. Terrett and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Combinatorial chemistry categories.
Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context.It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes thebeneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists inchemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.
Combinatorial Chemistry Part B
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Author :
language : en
Publisher: Elsevier
Release Date : 2004-01-26
Combinatorial Chemistry Part B written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-26 with Science categories.
Combinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions. *Analytical techniques*Direct sorting split and pool combinatorial synthesis*Linkers and their applications*Microwave assisted synthesis*Oligosaccharide chemistry*Peptide Synthesis and Screening*Polymer assisted approaches*Small molecule and heterocycle synthesis
Solid Phase Organic Synthesis
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Author : Patrick H. Toy
language : en
Publisher: John Wiley & Sons
Release Date : 2012-01-10
Solid Phase Organic Synthesis written by Patrick H. Toy and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-10 with Science categories.
Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments. Featuring chapters written by leading researchers in the field, Solid-Phase Organic Synthesis is divided into two parts: Part One, Concepts and Strategies, discusses the linker groups used to attach the synthesis substrate to the solid support, colorimetric tests to identify the presence of functional groups, combinatorial synthesis, and diversity-oriented synthesis. Readers will discover how solid-phase synthesis is currently used to facilitate the discovery of new molecular functionality. The final chapter discusses how using a support can change or increase reaction selectivity. Part Two, Applications, presents examples of the solid-phase synthesis of various classes of organic molecules. Chapters explore general asymmetric synthesis on a support, strategies for heterocyclic synthesis, and synthesis of radioactive organic molecules, dyes, dendrimers, and oligosaccharides. Each chapter ends with a set of conclusions that underscore the key concepts and methods. References in each chapter enable readers to investigate any topic in greater depth. With its presentation of basic concepts as well as recent findings and applications, Solid-Phase Organic Synthesis is the ideal starting point for students and researchers in organic, medicinal, and combinatorial chemistry who want to take full advantage of current solid-phase synthesis techniques.
Optimization Of Solid Phase Combinatorial Synthesis
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Author : Bing Yan
language : en
Publisher: CRC Press
Release Date : 2001-12-04
Optimization Of Solid Phase Combinatorial Synthesis written by Bing Yan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-12-04 with Science categories.
"Addresses the key topic in combinatorial synthesis--how to optimize the quality of a combinatorial library--by determining the usefulness of synthesized compunds, the reliability of biological assay results, and analyzing acadmic and industrial applications, real-world examples, and case studies of successful and unsuccessful technologies."
Combinatorial Chemistry
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Author : Guillermo A. Morales
language : en
Publisher: Academic Press
Release Date : 2003
Combinatorial Chemistry written by Guillermo A. Morales and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Amino acid sequence categories.
Combinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions. *Analytical techniques *Direct sorting split and pool combinatorial synthesis *Linkers and their applications *Microwave assisted synthesis *Oligosaccharide chemistry *Peptide Synthesis and Screening *Polymer assisted approaches *Small molecule and heterocycle synthesis.
Combinatorial Chemistry And Technology
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Author : Stanislav Miertus
language : en
Publisher: CRC Press
Release Date : 1999-07-01
Combinatorial Chemistry And Technology written by Stanislav Miertus and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-07-01 with Science categories.
"Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."
Combinatorial Strategies In Biology And Chemistry
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Author : Annette Beck-Sickinger
language : en
Publisher: John Wiley & Sons
Release Date : 2002-01-21
Combinatorial Strategies In Biology And Chemistry written by Annette Beck-Sickinger and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-21 with Science categories.
Combinatorial chemistry has taken the pharmaceutical industry by storm over the past ten to fifteen years. There has been a massive investment in automation by pharmaceutical companies and a demand for graduates/PhDs with experience and knowledge of combinatorial chemistry. These days the academic education of chemists and biologists is gradually converging, so those entering the pharmaceutical industry need to be not only chemistry graduates but also biologists applying their biological knowledge to chemistry. Many chemists, however, still require experience in biological methods and similarly biologists have not yet realized the power of chemical methods. This book will therefore help ease the transition from biology into chemistry and vice versa, for those working in the combinatorial chemistry field. Because combinatorial chemistry evolved from the requirements of the biology field, the authors have written this book with both biologists and chemists in mind. Combinatorial chemistry is a new and highly influential area of modern synthetic chemistry based on efficient, parallel synthesis of molecules, as opposed to the use of several synthetic steps, to produce many sets of compounds for biological evaluation. The techniques used in this area are key to the discovery of new drug compounds in the pharmaceutical and agrochemical industries. Combinatorial Methods in Chemistry and Biology describes the origins, basics and techniques used both in combinatorial chemistry and molecular biology. Key features: * First book to cover combinatorial methods in both chemistry and biology - ideal for those with either a chemical or biological background. * Introductory text - ideal for newcomers to the field. * Covers a wide swathe of techniques and topics - providing beginners with a complete overview of the field. * Contains chapters on supporting material and linkers, two important areas in the field. * Up-to-date and topical. This volume will be of key interest to technicians/scientists working in the pharmaceutical industry with backgrounds in either biology or chemistry. It will also be invaluable to students - postgraduates studying chemistry and molecular biology or those chemistry/molecular biology undergraduates at universities where combinatorial chemistry is taught as a module.