Combinatorial Library
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Combinatorial Library
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Author : Lisa B. English
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Combinatorial Library written by Lisa B. English and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.
Combinatorial Peptide And Nonpeptide Libraries
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Author : Günther Jung
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-26
Combinatorial Peptide And Nonpeptide Libraries written by Günther Jung and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-26 with Science categories.
With combinatorial chemistry millions of organic compounds can be produced simultaneously, quickly, and in most cases by automated procedures. These compound libraries are a cost-effective resource for the pharmaceutical industry in their search for biologically active lead structures. Furthermore simultaneous parallel synthesis of single peptides and peptide libraries solve the problem of the worldwide increasing demand for peptides. The synthetic methods described here in detail contribute to a forward-looking technology that has a high impact for industrial and academic research. Fast and efficient analytical techniques are essential for using the complicated product mixtures and detecting by-products. Various synthetic approaches and technologies, mass spectrometry, and screening assays are discussed extensively. This book is a must and an indispensible source of information for every researcher in this rapidly developing field, which spans organic synthesis, biochemistry, biotechnology, pharmaceutical, medicinal, and clinical chemistry.
Combinatorial Chemistry And Technologies
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Author : Stanislav Miertus
language : en
Publisher: CRC Press
Release Date : 2005-04-12
Combinatorial Chemistry And Technologies written by Stanislav Miertus and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-04-12 with Medical categories.
Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the
Structure Based Design Of Combinatorial Libraries
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Author : Allan Geoffrey Skillman
language : en
Publisher:
Release Date : 1999
Structure Based Design Of Combinatorial Libraries written by Allan Geoffrey Skillman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Combinatorial Chemistry
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Author : Günther Jung
language : en
Publisher: John Wiley & Sons
Release Date : 2008-07-11
Combinatorial Chemistry written by Günther Jung and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-11 with Science categories.
The story of success goes on and on - with a new book on combinatorial chemistry, edited by Gunther Jung! Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book, edited by Gunther Jung: The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry. This is the book written by specialists for specialists and for everyone aspiring to become an insider! It is an indispensible source of information for researchers working in organic synthesis, catalysis, biochemistry, and biotechnology, pharmaceutical and clinical chemistry, material sciences, and analytical chemistry.
Computational Phytochemistry
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Author : Satyajit Dey Sarker
language : en
Publisher: Elsevier
Release Date : 2024-03-06
Computational Phytochemistry written by Satyajit Dey Sarker and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-06 with Science categories.
Computational Phytochemistry, Second Edition, explores how recent advances in computational techniques and methods have been embraced by phytochemical researchers to enhance many of their operations, refocusing and expanding the possibilities of phytochemical studies. By applying computational aids and mathematical models to extraction, isolation, structure determination, and bioactivity testing, researchers can obtain highly detailed information about phytochemicals and optimize working approaches.This book aims to support and encourage researchers currently working with or looking to incorporate computational methods into their phytochemical work. Topics in this book include computational methods for predicting medicinal properties, optimizing extraction, isolating plant secondary metabolites, and building dereplicated phytochemical libraries. The roles of high-throughput screening, spectral data for structural prediction, plant metabolomics, and biosynthesis are all reviewed before the application of computational aids for assessing bioactivities and virtual screening is discussed. Illustrated with detailed figures and supported by practical examples, this book is an indispensable guide for all those involved with the identification, extraction, and application of active agents from natural products.This new edition captures remarkable advancements in mathematical modeling and computational methods that have been incorporated in phytochemical research, addressing, e.g., extraction, isolation, structure determination, and bioactivity testing of phytochemicals. - Includes step-by-step protocols for various computational and mathematical approaches applied to phytochemical research - Features clearly illustrated chapters contributed by highly reputable researchers - Covers all key areas in phytochemical research, including virtual screening and metabolomics
High Throughput Screening
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Author : John P. Devlin
language : en
Publisher: CRC Press
Release Date : 1997-05-06
High Throughput Screening written by John P. Devlin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-05-06 with Medical categories.
Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high
Applications Of Evolutionary Computation In Chemistry
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Author : H.M. Cartwright
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-03-12
Applications Of Evolutionary Computation In Chemistry written by H.M. Cartwright and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-12 with Computers categories.
H. M. Cartwright: An Introduction to Evolutionary Computation andEvolutionary Algorithms; B. Hartke: Application of Evolutionary Algorithms to Global Cluster Geometry Optimization; K.D.M. Harris, R.L. Johnston, S. Habershon: Application of Evolutionary Computation in Structure Solution from Diffraction Data; S. M.
Immunological Recognition Of Peptides In Medicine And Biology
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Author : N. D. Zegers
language : en
Publisher: CRC Press
Release Date : 1995-07-19
Immunological Recognition Of Peptides In Medicine And Biology written by N. D. Zegers and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-07-19 with Medical categories.
Immunological Recognition of Peptides in Medicine and Biology gives a state-of-the-art overview on the use of peptides and peptide-ligand interactions, and the critical role they play in recognition patterns for the regulation of various biological functions. A wide range of applications are discussed, including some experimental preclinical ones such as epitope mapping, peptide libraries, and production of amino acid-specific antibodies and their therapeutic use in oncology and infectious disease vaccines. Each chapter also includes step-by-step protocols to aid in actual experiments. Several alternative techniques and strategies are discussed by different authors offering the reader an opportunity to select the most favorable application for a specific biological problem.
Constitutional Dynamic Chemistry
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Author : Mihail Barboiu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-06
Constitutional Dynamic Chemistry written by Mihail Barboiu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-06 with Science categories.
Constitutional Dynamic Chemistry: Bridge from Supramolecular Chemistry to Adaptive Chemistry, by Jean-Marie Lehn Multistate and Phase Change Selection in Constitutional Multivalent Systems, by Mihail Barboiu Dynamic Systemic Resolution, by Morakot Sakulsombat, Yan Zhang and Olof Ramström Dynamic Combinatorial Self-Replicating Systems, by Emilie Moulin and Nicolas Giuseppone DCC in the Development of Nucleic Acid Targeted and Nucleic Acid Inspired Structures, by Benjamin L. Miller Dynamic Nanoplatforms in Biosensor and Membrane Constitutional Systems, by Eugene Mahon, Teodor Aastrup und Mihail Barboiu Dynamic Assembly of Block-Copolymers, by D. Quémener, A. Deratani und S. Lecommandoux Dynamic Chemistry of Anion Recognition, by Radu Custelcean Supramolecular Naphthalenediimide Nanotubes, by Nandhini Ponnuswamy, Artur R. Stefankiewicz, Jeremy K. M. Sanders und G. Dan Pantoş Synthetic Molecular Machines and Polymer/Monomer Size Switches that Operate Through Dynamic and Non-Dynamic Covalent Changes, by Adrian-Mihail Stadler und Juan Ramírez Reversible Covalent Chemistries Compatible with the Principles of Constitutional Dynamic Chemistry: New Reactions to Create More Diversity, by Kamel Meguellati und Sylvain Ladame.