Comparative Chemical Mutagenesis

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Comparative Chemical Mutagenesis

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Author : Frederick De Serres
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-12

Comparative Chemical Mutagenesis written by Frederick De Serres and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-12 with Science categories.

Frederick J. de Serres, Ph. D. Office of the Associate Director for Genetics National Institute of Environmental Health Sciences Research Triangle Park, North Carolina (U. S. A. ) 27709 The Workshop on Comparative Chemical Mutagenesis was orga nized to begin the process of problem identification and resolution concerning our needs to evaluate the data on test chemicals arising from assays for mutagenic activity on laboratory organisms. In the past, data on chemical mutagens has been generated and published in the scientific literature on a more or less random basis. Individual chemicals enjoy a brief period of "popularity" that leads to a burst of publications in the same or sometimes related assay systems. The incompleteness of the data base, in many of these cases, makes comparative mutagenesis difficult or impossible. In our attempts to compare the genetic effects of a given chemical over a wide range of assay systems, we are often interested in making quantitative as well as qualitative compari sons. To restate the first comparison: is the chemical under ques tion a weak, moderate or potent mutagen over a wide range of assay systems--or alternatively, does the level of response vary markedly? To make the second comparison, what is needed is information on the spectrum of genetic alterations produced as well as whether this spectrum is consistent over a wide range of organisms.

Comparative Chemical Mutagenesis

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Author : M. D. ed SHELBY
language : en
Publisher:
Release Date : 1981

Comparative Chemical Mutagenesis written by M. D. ed SHELBY and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with categories.

Comparative Chemical Mutagenesis

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Author : Frederick De Serres
language : en
Publisher:
Release Date : 2014-01-15

Comparative Chemical Mutagenesis written by Frederick De Serres and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.

Comparative Chemical Mutagenesis Volume 24

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Author : FJ De Serres (Ed)
language : en
Publisher:
Release Date : 1981

Comparative Chemical Mutagenesis Volume 24 written by FJ De Serres (Ed) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with categories.

Session G Comparative Studies Of Radiation And Chemical Mutagenesis Ii

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Author : A. Nasim
language : en
Publisher:
Release Date : 1969

Session G Comparative Studies Of Radiation And Chemical Mutagenesis Ii written by A. Nasim and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1969 with categories.

Chemical Mutagens

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Author : Alexander Hollaender
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Chemical Mutagens written by Alexander Hollaender and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

The ready acceptance and wide demand for copies of the first two volumes of Chemical Mutagens: Principles and Methods Jar Their Detection have demon strated the need for wider dissemination of information on this timely and urgent subject. Therefore, it was imperative that a third volume be prepared to include more detailed discussions on techniques of some of the methods that were presented from a theoretical point of view in the first two volumes, and to update this rapidly expanding field with current findings and the new developments that have taken place in the past three years. Also included is a special chapter by Dr. Charlotte Auerbach giving the historical background of the discovery of chemical mutagenesis. Methods for recognizing mutagenic compounds in vitro are a necessary preliminary step toward arriving at satisfactory solutions for recognizing significant mutation rates in man, which must be done before our test tube methods of detection can be considered reliable. Two chapters in this volume make important contributions to this problem. Due to the increasing activity in efforts to perfect techniques for detecting chemical mutagens and their effects on man, it is planned to continue this series of volumes as necessary to keep abreast of current findings.

Chemical Mutagens

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Author : Alexander Hollaender
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Chemical Mutagens written by Alexander Hollaender and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Volume 9 of Chemical Mutagens consists mainly of chapters discussing the development and validation of short-term assays to detect the mutagenic effects of environmental chemicals. These chapters include an assay with the grasshopper neuroblast, a comparison of mutagenic responses of human lung-derived and skin-derived diploid fibroblasts, a forward-mutation assay in Salmonella, a multigene sporulation test in Bacillus subtilis, a specific locus assay in mouse lymphoma cells, a study of the induction of bacteriophage lambda, and the granuloma pouch assay. In addition, there are two chapters on the identification of mutagens in cooked food and in human feces. Frederick 1. de Serres Research Triangle Park, North Carolina vii Contents Chapter 1 The Grasshopper Neuroblast Short-Term Assay for Evaluating the Effects of Environmental Chemicals on Chromosomes and Cell Kinetics 1 Mary Esther Gaulden, Jan C. Liang, and Martha J. Ferguson 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Embryo Supply. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 1. Species. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 2. Origin of Colonies . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 3. Life Cycle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. 4. Colony Maintenance . . . . . . . . . . . . . . . . . . . . . . . . . 6 2. 5. Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 2. 6. Allergy to Grasshoppers . . . . . . . . . . . . . . . . . . . . . . 14 3. Grasshopper Egg, Embryo, and Cells . . . . . . . . . . . . . . . . . 14 3. 1. The Egg Shell and Membranes . . . . . . . . . . . . . . . . . 14 3. 2. Embryonic Development . . . . . . . . . . . . . . . . . . . . . . 17 3. 3. Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 4. Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 4. 1. Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 4. 2. Preparation of Embryos for Cell Analysis . . . . . . . . . 34 4. 3. Analysis of Mutagen Effects. . . . . . . . . . . . . . . . . 40 . . . 5. Response of the Grasshopper Neuroblast to Mutagens . . . . 50 5. 1. Reproducibility of Data . . . . . . . . . . . . . . . . . . . . . . . 50 5. 2. Radiation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 5. 3. Chemical Mutagens . . . . . . . . . . . . . . . . . . . . . . . . . .

Chemical Mutagenesis In Mammals And Man

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Author : F. Vogel
language : en
Publisher: Springer
Release Date : 2012-05-05

Chemical Mutagenesis In Mammals And Man written by F. Vogel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-05 with Medical categories.

Encouraged by the results with radiation genetics, the editors of this volume have tried since 1963 to organize a team of scientists in Heidelberg who would examine the problem of chemical mutagenesis in mammals with a variety of methods. Meanwhile, other organizations have also become interested in this problem and various teams, particularly in the U.S.A., but also in West Germany, are working in this field. This development is very auspicious; the spectrum of our methods does permit limited conclusions as to the mutagenic effects of chemical substances in mammals, but we are still far away from a thorough determination of all the genetically relevant effects. New methods must be developed. This volume is the result of a request by the Chairman of the "Gesellschaft fUr Anthropologie und Humangenetik", Frau Professor Dr. I. SCHWIDETZKY (Mainz), that one of us (F.V.) organize a symposium concerning mutation research in the framework of its annual meeting on October 7, 1969. The most sensible approach seemed to be one of centering the discussion on the test methods employed in mutagenicity research with mammals. With the aid of the Deutsche Forschungsgemeinschaft and the pharma­ ceutical industry it was possible to invite scientists from the U.S.A. We wish to thank Firma Thomae, Biberach, Firma Bayer, Leverkusen, and Firma Boehringer, Mannheim, for their contributions. We wish to thank Dr. HAsso SCHROEDER especially for his efforts on our behalf.

Comparative Study Of Chemical And Physical Mutagens For Qualitative And Quantitative Characters

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Author : Y. G. Khamankar
language : en
Publisher:
Release Date : 1974

Comparative Study Of Chemical And Physical Mutagens For Qualitative And Quantitative Characters written by Y. G. Khamankar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with categories.

Assessing Chemical Mutagens The Risk To Humans Volume 1

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Author : S ABRAHAMSON (Ed)
language : en
Publisher:
Release Date : 1979

Assessing Chemical Mutagens The Risk To Humans Volume 1 written by S ABRAHAMSON (Ed) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with categories.

1 MUTATION AND DISEASE IN HUMANS. 2 STRENGTHS AND WEAKNESSES OF TESTS FOR MUTAGENESIS. 3 BACTERIAL MUTAGENICITY TESTING: SOME PRACTICAL CONSIDERATIONS. 4 THEORY AND DESIGN OF SHORT TERM BACTERIAL TESTS FOR MUTAGENESIS. 5 DNA REPAIR. 6 CYTOGENETIC STUDIES AND RISK ASSESSMENT FOR CHEMICALS AND IONIZING RADIATION. 7 RADIATION INDUCED CANCER. 8 LOW DOSE AND SPECIES TO SPECIES EXTRAPOLATION FOR CHEMICALLY INDUCED CARCINOGENESIS. 9 ESTIMATING RADIATION INDUCED CARCINOGENESIS. 10 RISK ASSESSMENT OF ETHYLENE OXIDE AND OTHER COMPOUNDS. 11 DOSIMETRY OF ALKYLATING AGENTS. 12 ARE BENZENE EFFECTS LIMITED TO THE CHROMOSOMAL LEVEL?. 13 GENERAL ASPECTS OF COMPARATIVE MUTAGENESIS.