Chemical Mutagenesis In Mammals And Man
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Chemical Mutagenesis In Mammals And Man
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Author : F Vogel (Ed)
language : en
Publisher:
Release Date : 1970
Chemical Mutagenesis In Mammals And Man written by F Vogel (Ed) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Science categories.
Chemical Mutagenesis In Laboratory Mammals
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Author :
language : en
Publisher:
Release Date : 1973
Chemical Mutagenesis In Laboratory Mammals written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Chemical mutagenesis categories.
Over 350 references to books and journal articles published during 1928-1973. Also covers foreign-language literature. Arranged under citation index, Agent index, Chemical abstracts registry number index, Organism index, KWIC index, Author index, First author index, and Addendum. Entries in Citation index and First author index provide essential bibliographical information.
Chemical Mutagens
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Author : Alexander Hollaender
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Chemical Mutagens written by Alexander Hollaender and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The ready acceptance and wide demand for copies of the first two volumes of Chemical Mutagens: Principles and Methods Jar Their Detection have demon strated the need for wider dissemination of information on this timely and urgent subject. Therefore, it was imperative that a third volume be prepared to include more detailed discussions on techniques of some of the methods that were presented from a theoretical point of view in the first two volumes, and to update this rapidly expanding field with current findings and the new developments that have taken place in the past three years. Also included is a special chapter by Dr. Charlotte Auerbach giving the historical background of the discovery of chemical mutagenesis. Methods for recognizing mutagenic compounds in vitro are a necessary preliminary step toward arriving at satisfactory solutions for recognizing significant mutation rates in man, which must be done before our test tube methods of detection can be considered reliable. Two chapters in this volume make important contributions to this problem. Due to the increasing activity in efforts to perfect techniques for detecting chemical mutagens and their effects on man, it is planned to continue this series of volumes as necessary to keep abreast of current findings.
Comparative Chemical Mutagenesis
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Author : Frederick De Serres
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-12
Comparative Chemical Mutagenesis written by Frederick De Serres and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-12 with Science categories.
Frederick J. de Serres, Ph. D. Office of the Associate Director for Genetics National Institute of Environmental Health Sciences Research Triangle Park, North Carolina (U. S. A. ) 27709 The Workshop on Comparative Chemical Mutagenesis was orga nized to begin the process of problem identification and resolution concerning our needs to evaluate the data on test chemicals arising from assays for mutagenic activity on laboratory organisms. In the past, data on chemical mutagens has been generated and published in the scientific literature on a more or less random basis. Individual chemicals enjoy a brief period of "popularity" that leads to a burst of publications in the same or sometimes related assay systems. The incompleteness of the data base, in many of these cases, makes comparative mutagenesis difficult or impossible. In our attempts to compare the genetic effects of a given chemical over a wide range of assay systems, we are often interested in making quantitative as well as qualitative compari sons. To restate the first comparison: is the chemical under ques tion a weak, moderate or potent mutagen over a wide range of assay systems--or alternatively, does the level of response vary markedly? To make the second comparison, what is needed is information on the spectrum of genetic alterations produced as well as whether this spectrum is consistent over a wide range of organisms.
Mutations In Man
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Author : G. Obe
language : en
Publisher: Springer
Release Date : 1984
Mutations In Man written by G. Obe and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Science categories.
Chemical Mutagens
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Author : Alexander Hollaender
language : en
Publisher: Springer
Release Date : 1971
Chemical Mutagens written by Alexander Hollaender and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1971 with Medical categories.
The ready acceptance and wide demand for copies of the first two volumes of Chemical Mutagens: Principles and Methods Jar Their Detection have demon strated the need for wider dissemination of information on this timely and urgent subject. Therefore, it was imperative that a third volume be prepared to include more detailed discussions on techniques of some of the methods that were presented from a theoretical point of view in the first two volumes, and to update this rapidly expanding field with current findings and the new developments that have taken place in the past three years. Also included is a special chapter by Dr. Charlotte Auerbach giving the historical background of the discovery of chemical mutagenesis. Methods for recognizing mutagenic compounds in vitro are a necessary preliminary step toward arriving at satisfactory solutions for recognizing significant mutation rates in man, which must be done before our test tube methods of detection can be considered reliable. Two chapters in this volume make important contributions to this problem. Due to the increasing activity in efforts to perfect techniques for detecting chemical mutagens and their effects on man, it is planned to continue this series of volumes as necessary to keep abreast of current findings.
Identifying And Estimating The Genetic Impact Of Chemical Mutagens
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Author : National Research Council (U.S.). Committee on Chemical Environmental Mutagens
language : en
Publisher:
Release Date : 1983
Identifying And Estimating The Genetic Impact Of Chemical Mutagens written by National Research Council (U.S.). Committee on Chemical Environmental Mutagens and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Medical categories.
And conclusions; Introduction; A primer on genetics, mutation, mutagens, and the implications of mutagenesis; Metabolism and pharmacologic disposition of mutagens and promutagens; The nature of test systems; Strategies for risk assessment: the choice and use of test systems to estimative human germinal mututation; Strategies for risk assessment: relation between mutation rate and human welfare; Testing and monitoring human populations; A mutagen assessment program; Some additional issues and research suggestions.
Mutagenesis In Sub Mammalian Systems
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Author : G.E. Paget
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mutagenesis In Sub Mammalian Systems written by G.E. Paget and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Topics in Toxicology Toxicology is a science that stands at the intersection of several interests and disciplines. These intersecting forces are by no means all scientific since some are legal and some are commercial. All have valid things to say about the conduct and interpretation of toxicity experiments. The practising toxicologist must bear all these sometimes conflicting forces in mind as he carries out his duties. This is especially true, of course, of the toxicologist in industry. Toxicology is also a field in which contract research particularly flourishes and a number of major contract research companies have established over the years a reputation for contributing usefully to the practice of this skill. These contract research organisations are particu larly favoured to develop an appreciation of the problems of the industrial toxicologist, since it is very common for such a company to service the toxicological needs of companies in several sectors of industry producing new chemical compounds, and the contract research company, therefore, is aware of a wider diversity of problems than probably affects a single toxicologist in one industry.
Chemical Mutagens
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Author : Frederick J. De Serr
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Chemical Mutagens written by Frederick J. De Serr and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Volume 8 of Chemical Mutagens covers a wide range of topics in this continuously changing field. This volume includes chapters on the detection of genetic damage in mammalian sperm both at specific loci and over the entire genome. The discussion of in vitro techniques for working with mammalian cells covers not only specific locus assays but also cellular activation systems. Another chapter extensively discusses the need for a revised protocol for the micronucleus assay. Structure activity relationships are investigated in a chapter dealing with hair dye constituents. One of the most comprehensive chapters deals with problems associated with the detection of mutagenic effects in defined human populations. Finally, there is a detailed presentation of a comprehensive study tabulating the genetic bioassay data on some known or suspected human carcinogens. In keeping with our policy of publishing important legislation in the area of chemical mutagens, we have also included the Council of the European Communities Directive of 18 September 1979. Frederick J. de Serres Research Triangle Park, North Carolina vii Contents Chapter 1 Detection of Effects of Mutagens in Human Populations George R. Hoffmann 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Monitoring Progeny for Evidence of Germ-Cell Mutations. . . . . 3 2. 1. The Classical Approach: Phenotypic Monitoring . . . . . . . 3 2. 2. Monitoring for Changes in Gene Products . . . . . . . . . . . 7 3. Detection of Gene Mutations in Somatic Cells. . . . . . . . . . . . . 9 3. 1. Drug-Resistant Lymphocytes . . . . . . . . . . . . . . . . . . . . . . 9 3. 2. Hemoglobin Variants . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4. Nongenetic Indicators of Mutagen Exposure . . . . . . . . . . . . . 21 4. 1. Alkylation of Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 4. 2. DNA Damage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Chemical Mutagens
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Author : Frederick J. de Serres
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Chemical Mutagens written by Frederick J. de Serres and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
New developments in the study of environmental mutagens continue to evolve in this rapidly emerging field. In Volume 7 of Chemical Mutagens, we have focused on various new techniques for the detection of genetic damage in somatic cells and germ cells of mammals and the use of lower eukaryotic microorganisms to detect aneuploidy as well as other types of genetic damage. Attention has also been given to the role of in vitro metabolic activation as a mechanism for modifying the genetic effects of different environmental chemicals. In a chapter on compar ative mutagenesis, reaction kinetics and their relationship to the mu tagenic action of monofunctional alkylating agents in higher eukaryotic organisms are examined. In another chapter, the pharmacology and toxicology of nitrites and nitrates, which are in widespread distribution in the environment, are discussed in detail. The books in this series have provided a mechanism for the publication of many important new developments in the study of the genetic effects of environmental chemicals. This series was launched by Dr. Alexander Hollaender who, beginning in 1971, edited Volumes 1-4 and then coedited Volumes 5-7. The success of his lO-year effort with these volumes is another testimony to Dr. Hollaender's many contri butions to the field of environmental mutagenesis. As Dr.