Computational And Experimental Protein Variant Interpretation In The Era Of Precision Medicine
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Computational And Experimental Protein Variant Interpretation In The Era Of Precision Medicine
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Author : Daniele Dell'Orco
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-26
Computational And Experimental Protein Variant Interpretation In The Era Of Precision Medicine written by Daniele Dell'Orco and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-26 with Science categories.
One of the key goals in the postgenomic era is the elucidation of the mechanisms underlying the relationship between genotype and phenotype. In particular, understanding how human genetic and somatic variations are associated with diseases is still an open problem and its solution is a crucial issue for exploiting the possibilities offered by the modern sequencing techniques in the framework of precision and personalized medicine. The increasing amount of data generated by the sequencing initiatives calls for accurate and reliable computational approaches to predict the impact of mutations on the phenotype, and possibly for methods to correlate them with diseases. From the experimental point of view, disease-causing variants are supposed to directly affect protein function, protein stability as well as the kinetics and thermodynamics of protein-protein recognition, and robust validation at the molecular scale is necessary. This approach can be of invaluable help in facing new challenges such as the fast development of effective vaccines.
Encyclopedia Of Bioinformatics And Computational Biology
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Author :
language : en
Publisher: Elsevier
Release Date : 2018-08-21
Encyclopedia Of Bioinformatics And Computational Biology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-21 with Medical categories.
Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases
Personalized Medicine
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-01-28
Personalized Medicine written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-28 with Science categories.
The Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. - Provides cutting-edge developments in protein chemistry and structural biology - Chapters are written by authorities in their field - Targeted to a wide audience of researchers, specialists, and students
Computational Genomics And Structural Bioinformatics In Personalized Medicines Volume Ii
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Author : George Priya Doss C
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-06
Computational Genomics And Structural Bioinformatics In Personalized Medicines Volume Ii written by George Priya Doss C and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-06 with Medical categories.
Bioinformatics Analysis Of Single Cell Sequencing Data And Applications In Precision Medicine
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Author : Jialiang Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2020-02-27
Bioinformatics Analysis Of Single Cell Sequencing Data And Applications In Precision Medicine written by Jialiang Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-27 with categories.
Bioinformatics
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Author : Dev Bukhsh Singh
language : en
Publisher: Academic Press
Release Date : 2021-10-21
Bioinformatics written by Dev Bukhsh Singh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-21 with Medical categories.
Bioinformatics: Methods and Applications provides a thorough and detailed description of principles, methods, and applications of bioinformatics in different areas of life sciences. It presents a compendium of many important topics of current advanced research and basic principles/approaches easily applicable to diverse research settings. The content encompasses topics such as biological databases, sequence analysis, genome assembly, RNA sequence data analysis, drug design, and structural and functional analysis of proteins. In addition, it discusses computational approaches for vaccine design, systems biology and big data analysis, and machine learning in bioinformatics.It is a valuable source for bioinformaticians, computer biologists, and members of biomedical field who needs to learn bioinformatics approaches to apply to their research and lab activities. - Covers basic and more advanced developments of bioinformatics with a diverse and interdisciplinary approach to fulfill the needs of readers from different backgrounds - Explains in a practical way how to decode complex biological problems using computational approaches and resources - Brings case studies, real-world examples and several protocols to guide the readers with a problem-solving approach
Computational Genomics And Structural Bioinformatics In Personalized Medicines
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Author : George Priya Doss C
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-26
Computational Genomics And Structural Bioinformatics In Personalized Medicines written by George Priya Doss C and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-26 with Medical categories.
10 Years Of Pharmacogenetics And Pharmacogenomics
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Author : Jose Agundez
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-08
10 Years Of Pharmacogenetics And Pharmacogenomics written by Jose Agundez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-08 with categories.
The Specialty Section “Pharmacogenetics and Pharmacogenomics” makes part of two different Journals: Frontiers in Pharmacology and Frontiers in Genetics. This Specialty Section focuses on the mechanisms by which genetic variations influence drug effects and adverse drug events, and cover basic research, clinical translation, applications in drug development and regulatory issues related to this field. Also, studies addressing the role of other factors such as epigenetics, phenotypic factors or drug-drug interactions on drug pharmacokinetics or pharmacodynamics are welcome. The editorial board is composed of 34 Associate Editors which, together with the Guest Associate Editors and the Reviewer Editors, constitute a team of nearly 340 leading experts in the field of Pharmacogenetics and Pharmacogenomics. This guarantees high quality in the reviewing process as well as short review times. A look back: 10 years of Frontiers in Pharmacogenetics & Pharmacogenomics (Continued in eBook)
Next Generation Sequencing In Pharmacogenetics Genomics
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Author : Ulrich M. Zanger
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-28
Next Generation Sequencing In Pharmacogenetics Genomics written by Ulrich M. Zanger and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-28 with categories.
Genomic And Personalized Medicine
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Author :
language : en
Publisher: Academic Press
Release Date : 2008-11-11
Genomic And Personalized Medicine written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-11 with Science categories.
This two-volume set — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — provides an in-depth look at one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. The inclusion of the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more presents this book as an essential tool for both students and specialists across many biological and medical disciplines, including human genetics and genomics, oncology, neuroscience, cardiology, infectious disease, molecular medicine, and biomedical science, as well as health policy disciplines focusing on ethical, legal, regulatory and economic aspects of genomics and medicine.Volume One Includes:Principles, Methodology and Translational Approaches, takes readers on the journey from principles of human genomics to technology, informatic and computational platforms for genomic medicine, as well as strategies for translating genomic discoveries into advances in personalized clinical care.Volume Two Includes:Genome Discoveries and Clinical Applications presents the latest developments in disease-based genomic and personalized medicine. With chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, this work provides the most comprehensive guide to the principles and practice of genomic and personalized medicine. - Highly Commended 2013 BMA Medical Book Award for Medicine - Contributions from leaders in the field provide unparalleled insight into current technologies and applications in clinical medicine. - Full colour throughout enhances the utility of this work as the only available comprehensive reference for genomic and personalized medicine. - Discusses scientific foundations and practical applications of new discoveries, as well as ethical, legal/regulatory, and social issues related to the practice of genomic medicine.