Computational Chemogenomics
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Computational Chemogenomics
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Author : Edgar Jacoby
language : en
Publisher: CRC Press
Release Date : 2013-12-03
Computational Chemogenomics written by Edgar Jacoby and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-03 with Medical categories.
This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analys
Computational Chemogenomics
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Author : Edgar Jacoby
language : en
Publisher: CRC Press
Release Date : 2013-12-03
Computational Chemogenomics written by Edgar Jacoby and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-03 with Medical categories.
This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead to the discovery of new medicines.
Computational Immunology
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Author : Shyamasree Ghosh
language : en
Publisher: CRC Press
Release Date : 2020-01-31
Computational Immunology written by Shyamasree Ghosh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-31 with Medical categories.
Computational Immunology: Applications focuses on different mathematical models, statistical tools, techniques, and computational modelling that helps in understanding complex phenomena of the immune system and its biological functions. The book also focuses on the latest developments in computational biology in designing of drugs, targets, biomarkers for early detection and prognosis of a disease. It highlights the applications of computational methods in deciphering the complex processes of the immune system and its role in health and disease. This book discusses the most essential topics, including Next generation sequencing (NGS) and computational immunology Computational modelling and biology of diseases Drug designing Computation and identification of biomarkers Application in organ transplantation Application in disease detection and therapy Computational methods and applications in understanding of the invertebrate immune system S Ghosh is MSc, PhD, PGDHE, PGDBI, is PhD from IICB, CSIR, Kolkata, awarded the prestigious National Scholarship from the Government of India. She has worked and published extensively in glycobiology, sialic acids, immunology, stem cells and nanotechnology. She has authored several publications that include books and encyclopedia chapters in reputed journals and books.
In Silico Drug Design
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Author : Kunal Roy
language : en
Publisher: Academic Press
Release Date : 2019-02-12
In Silico Drug Design written by Kunal Roy and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-12 with Medical categories.
In Silico Drug Design: Repurposing Techniques and Methodologies explores the application of computational tools that can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate and analyze datasets from diverse sources. Other topics include in silico drug design methods, computational workflows for drug repurposing, and network-based in silico screening for drug efficacy. With contributions from experts in the field and the inclusion of practical case studies, this book gives scientists, researchers and R&D professionals in the pharmaceutical industry valuable insights into drug design. - Discusses the theoretical background and methodologies of useful techniques of cheminformatics and bioinformatics that can be applied for drug repurposing - Offers case studies relating to the in silico modeling of FDA-approved drugs for the discovery of antifungal, anticancer, antiplatelet agents, and for drug therapies against diseases - Covers tools and databases that can be utilized to facilitate in silico methods for drug repurposing
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2004
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Secondary Metabolites And Volatiles Of Pgpr In Plant Growth Promotion
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Author : R. Z. Sayyed
language : en
Publisher: Springer Nature
Release Date : 2022-10-30
Secondary Metabolites And Volatiles Of Pgpr In Plant Growth Promotion written by R. Z. Sayyed and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-30 with Science categories.
This contributed volume explores how plant growth-promoting rhizobacterias (PGPR) provide a wide range of benefits to the plant. Further, it discusses the key roles PGPR play in nutrient acquisition and assimilation, improved soil texture, secreting, and modulating extracellular molecules. The book outlines how plant secondary metabolites are natural sources of biologically active compounds used in a wide range of applications, and surveys the significant role of volatile organic compounds (VOCs) in plant communication by mediating above- and below-ground interactions between plants and the surrounding organisms. This volume compiles research from leading scientists from across the globe, linking the translation of basic knowledge to innovative applied research. The book focuses on the following three categories: 1) understanding the secondary metabolites produced by PGPR, the signaling mechanisms and how they affect plant growth, 2) the plausible role of volatile organic compounds produced by PGPR, their role and the signaling mechanism for plant growth promotion, and 3) Applications of VOCs and secondary metabolites of PGPR for seed germination, plant growth promotion; stress tolerance and in-plant health and immunity.
Computer Applications In Pharmaceutical Research And Development
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Author : Sean Ekins
language : en
Publisher: John Wiley & Sons
Release Date : 2006-07-11
Computer Applications In Pharmaceutical Research And Development written by Sean Ekins and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-11 with Medical categories.
A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Chapters are organized into the following sections: * Computers in pharmaceutical research and development: a general overview * Understanding diseases: mining complex systems for knowledge * Scientific information handling and enhancing productivity * Computers in drug discovery * Computers in preclinical development * Computers in development decision making, economics, and market analysis * Computers in clinical development * Future applications and future development Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book's cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.
Epi Informatics
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Author : Jose Medina-Franco
language : en
Publisher: Academic Press
Release Date : 2016-02-24
Epi Informatics written by Jose Medina-Franco and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-24 with Medical categories.
Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate these techniques into their own drug discovery projects that may involve chemical synthesis and medium- or high-throughput screening. In addition, this book highlights the significance of epigenetic targets to the public health for molecular modelers and chemoinformatians. The goal of this reference is to stimulate ongoing multidisciplinary research and to further improve current computational methodologies and workflows in order to accelerate the discovery and development of epi-drugs and epi-probes. - Focuses on the discovery of epi-drugs as candidates to be used in therapy including combined therapies - Describes new computational methodologies and screening assays utilizing recent and emerging novel structural data - Highlights the discovery, development and optimization of epi-probes, which are molecular probes that elucidate epigenetic mechanisms - Includes important topics such as computational-guided optimization of epi-hits, virtual screening to identify novel compounds for epigenetic targets, development and mining of epigenetic molecular databases, SAR modeling of screening data and much more
Approaches To Human Centered Ai In Healthcare
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Author : Grover, Veena
language : en
Publisher: IGI Global
Release Date : 2024-03-11
Approaches To Human Centered Ai In Healthcare written by Grover, Veena and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-11 with Computers categories.
The integration of artificial intelligence (AI) stands as both a promise and a challenge in the field of healthcare. As technological advancements reshape the industry, academic scholars find themselves at the forefront of a crucial dialogue about the ethical implications and societal repercussions of AI. The accelerating sophistication of AI technologies brings forth a central dilemma: how to maintain the crucial human touch required for compassionate and effective patient care in the face of unprecedented technical progress. This challenge is not only a theoretical concern but a pressing reality as healthcare systems increasingly rely on AI-driven solutions. Approaches to Human-Centered AI in Healthcare emerges as a significant guide, offering a comprehensive exploration of the opportunities and challenges entwined with the integration of AI into healthcare. The book becomes a critical compass, navigating readers through the intricate intersections of AI and patient care. By delving into real-world case studies, cutting-edge research findings, and practical recommendations, it provides a roadmap for scholars to navigate the complexities of healthcare AI. In doing so, it aims not only to inform but to shape the discourse around the responsible integration of AI, ensuring that the fundamental principles of compassionate patient care remain at the forefront.
Chemoinformatics Approaches To Structure And Ligand Based Drug Design
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Author : Adriano D. Andricopulo
language : en
Publisher: Frontiers Media SA
Release Date : 2019-02-05
Chemoinformatics Approaches To Structure And Ligand Based Drug Design written by Adriano D. Andricopulo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-05 with categories.
Chemoinformatics is paramount to current drug discovery. Structure- and ligand-based drug design strategies have been used to uncover hidden patterns in large amounts of data, and to disclose the molecular aspects underlying ligand-receptor interactions. This Research Topic aims to share with a broad audience the most recent trends in the use of chemoinformatics in drug design. To that end, experts in all areas of drug discovery have made their knowledge available through a series of articles that report state-of-the-art approaches. Readers are provided with outstanding contributions focusing on a wide variety of topics which will be of great value to those interested in the many different and exciting facets of drug design.