Computational Epidemiology Of Large Multi Dimensional Data Streams In Malaria And Covid 19
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Computational Epidemiology Of Large Multi Dimensional Data Streams In Malaria And Covid 19
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Author : Thu Tran
language : en
Publisher:
Release Date : 2023
Computational Epidemiology Of Large Multi Dimensional Data Streams In Malaria And Covid 19 written by Thu Tran and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Mathematical modeling plays a key role in helping us understand disease dynamics, answer counterfactual questions, and evaluating intervention strategies. This dissertation focuses on the utilization of computational tools to tackle challenges in public health, specifically in controlling and managing two of the high-mortality infectious diseases, Plasmodium falciparum malaria and COVID-19. I present an approach to estimate antimalarial drug efficacies for unobserved Plasmodium falciparum genotypes. This drug-by-genotype table allows mathematical models of drug resistance evolution to simulate the competition among any P.falciparum genotypes in any possible combination of available antimalarial drugs. I then use these estimates along with survey data on treatment-seeking behavior and drug choice to investigate the doubling time of kelch13 resistant genotypes in Sub-Saharan Africa. Kelch13 mutations which confer resistance to artemisinin have emerged as a major concern, threatening the efficacy of artemisinin-based combination therapies, especially in high malaria burden Sub-Sahara African countries. By assessing the risk of kelch13 variants being imported and selected for in this region, we can then explore drug resistance management strategies to slow their spread while increasing treatment access. The second half of this dissertation focuses on COVID-19. I evaluate various SARS-CoV-2 vaccine allocations to determine the optimal strategy to prevent the most number of COVID-19 deaths and hospitalizations for Rhode Island and Massachusetts under low, medium, and high transmission scenarios. In the last research chapter, I show how we can harness rich multi-dimensional data streams using mathematical model and statistical inference to estimate SARS-CoV-2 population immunity and attack rates in three southern New England states of the US. Being able to monitor these key epidemiological quantities in real-time will provide us with valuable insights into the population's susceptibility and help evaluate the effectiveness of various public health interventions.
Computational Epidemiology
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Author : Ellen Kuhl
language : en
Publisher:
Release Date : 2021
Computational Epidemiology written by Ellen Kuhl and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
This innovative textbook brings together modern concepts in mathematical epidemiology, computational modeling, physics-based simulation, data science, and machine learning to understand one of the most significant problems of our current time, the outbreak dynamics and outbreak control of COVID-19. It teaches the relevant tools to model and simulate nonlinear dynamic systems in view of a global pandemic that is acutely relevant to human health. If you are a student, educator, basic scientist, or medical researcher in the natural or social sciences, or someone passionate about big data and human health: This book is for you! It serves as a textbook for undergraduates and graduate students, and a monograph for researchers and scientists. It can be used in the mathematical life sciences suitable for courses in applied mathematics, biomedical engineering, biostatistics, computer science, data science, epidemiology, health sciences, machine learning, mathematical biology, numerical methods, and probabilistic programming. This book is a personal reflection on the role of data-driven modeling during the COVID-19 pandemic, motivated by the curiosity to understand it.
Computational Intelligence Methods In Covid 19 Surveillance Prevention Prediction And Diagnosis
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Author : Khalid Raza
language : en
Publisher: Springer Nature
Release Date : 2020-10-16
Computational Intelligence Methods In Covid 19 Surveillance Prevention Prediction And Diagnosis written by Khalid Raza and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-16 with Technology & Engineering categories.
The novel coronavirus disease 2019 (COVID-19) pandemic has posed a major threat to human life and health. This book is beneficial for interdisciplinary students, researchers, and professionals to understand COVID-19 and how computational intelligence can be used for the purpose of surveillance, control, prevention, prediction, diagnosis, and potential treatment of the disease. The book contains different aspects of COVID-19 that includes fundamental knowledge, epidemic forecast models, surveillance and tracking systems, IoT- and IoMT-based integrated systems for COVID-19, social network analysis systems for COVID-19, radiological images (CT, X-ray) based diagnosis system, and computational intelligence and in silico drug design and drug repurposing methods against COVID-19 patients. The contributing authors of this volume are experts in their fields and they are from various reputed universities and institutions across the world. This volume is a valuable and comprehensive resource for computer and data scientists, epidemiologists, radiologists, doctors, clinicians, pharmaceutical professionals, along with graduate and research students of interdisciplinary and multidisciplinary sciences.
Disease Control Priorities Third Edition Volume 6
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Author : King K. Holmes
language : en
Publisher: World Bank Publications
Release Date : 2017-11-06
Disease Control Priorities Third Edition Volume 6 written by King K. Holmes and has been published by World Bank Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-06 with Medical categories.
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Understanding Covid 19 The Role Of Computational Intelligence
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Author : Janmenjoy Nayak
language : en
Publisher: Springer Nature
Release Date : 2021-07-27
Understanding Covid 19 The Role Of Computational Intelligence written by Janmenjoy Nayak and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-27 with Technology & Engineering categories.
This book provides a comprehensive description of the novel coronavirus infection, spread analysis, and related challenges for the effective combat and treatment. With a detailed discussion on the nature of transmission of COVID-19, few other important aspects such as disease symptoms, clinical application of radiomics, image analysis, antibody treatments, risk analysis, drug discovery, emotion and sentiment analysis, virus infection, and fatality prediction are highlighted. The main focus is laid on different issues and futuristic challenges of computational intelligence techniques in solving and identifying the solutions for COVID-19. The book drops radiance on the reasons for the growing profusion and complexity of data in this sector. Further, the book helps to focus on further research challenges and directions of COVID-19 for the practitioners as well as researchers.
Global Infectious Disease Surveillance And Detection
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2007-11-11
Global Infectious Disease Surveillance And Detection written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-11 with Medical categories.
Early detection is essential to the control of emerging, reemerging, and novel infectious diseases, whether naturally occurring or intentionally introduced. Containing the spread of such diseases in a profoundly interconnected world requires active vigilance for signs of an outbreak, rapid recognition of its presence, and diagnosis of its microbial cause, in addition to strategies and resources for an appropriate and efficient response. Although these actions are often viewed in terms of human public health, they also challenge the plant and animal health communities. Surveillance, defined as "the continual scrutiny of all aspects of occurrence and spread of a disease that are pertinent to effective control", involves the "systematic collection, analysis, interpretation, and dissemination of health data." Disease detection and diagnosis is the act of discovering a novel, emerging, or reemerging disease or disease event and identifying its cause. Diagnosis is "the cornerstone of effective disease control and prevention efforts, including surveillance." Disease surveillance and detection relies heavily on the astute individual: the clinician, veterinarian, plant pathologist, farmer, livestock manager, or agricultural extension agent who notices something unusual, atypical, or suspicious and brings this discovery in a timely way to the attention of an appropriate representative of human public health, veterinary medicine, or agriculture. Most developed countries have the ability to detect and diagnose human, animal, and plant diseases. Global Infectious Disease Surveillance and Detection: Assessing the Challenges-Finding Solutions, Workshop Summary is part of a 10 book series and summarizes the recommendations and presentations of the workshop.
Global Public Health
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Author : Franklin White
language : en
Publisher: Oxford University Press
Release Date : 2013-03-14
Global Public Health written by Franklin White and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Medical categories.
Amid ongoing shifts world economic and political systems, the promise for future public health is more tenuous than ever. Will the today's economic systems sustain tomorrow's health? Will future generations inherit fair access to health and health care? The best hope for the health of future generations is the establishment of a well-grounded, global public health system for today. To that end, Global Public Health: Ecological Foundations addresses both the challenges and cooperative solutions of contemporary public health, all within a framework of social justice, environmental sustainability, and global cooperation. With an emphasis upon ecological foundations, this text approaches public health principles-history, foundations, topics, and applications-with a community-first perspective. By achieving global reach through cooperative, local interventions, this text illustrates that through the practice of public health we can also maintain the health of our world. Blending established wisdom with new perspectives, Global Public Health will stimulate better understanding of how the different streams of public health can work more synergistically to promote global health equity. It is a foundation on which future public health measures can be built and succeed.
The Impact Of Disasters And Crises On Agriculture And Food Security 2021
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Author : Food and Agriculture Organization of the United Nations
language : en
Publisher: Food & Agriculture Org.
Release Date : 2021-03-17
The Impact Of Disasters And Crises On Agriculture And Food Security 2021 written by Food and Agriculture Organization of the United Nations and has been published by Food & Agriculture Org. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-17 with Nature categories.
On top of a decade of exacerbated disaster loss, exceptional global heat, retreating ice and rising sea levels, humanity and our food security face a range of new and unprecedented hazards, such as megafires, extreme weather events, desert locust swarms of magnitudes previously unseen, and the COVID-19 pandemic. Agriculture underpins the livelihoods of over 2.5 billion people – most of them in low-income developing countries – and remains a key driver of development. At no other point in history has agriculture been faced with such an array of familiar and unfamiliar risks, interacting in a hyperconnected world and a precipitously changing landscape. And agriculture continues to absorb a disproportionate share of the damage and loss wrought by disasters. Their growing frequency and intensity, along with the systemic nature of risk, are upending people’s lives, devastating livelihoods, and jeopardizing our entire food system. This report makes a powerful case for investing in resilience and disaster risk reduction – especially data gathering and analysis for evidence informed action – to ensure agriculture’s crucial role in achieving the future we want.
Mathematical Epidemiology
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Author : Fred Brauer
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-04-30
Mathematical Epidemiology written by Fred Brauer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Medical categories.
Based on lecture notes of two summer schools with a mixed audience from mathematical sciences, epidemiology and public health, this volume offers a comprehensive introduction to basic ideas and techniques in modeling infectious diseases, for the comparison of strategies to plan for an anticipated epidemic or pandemic, and to deal with a disease outbreak in real time. It covers detailed case studies for diseases including pandemic influenza, West Nile virus, and childhood diseases. Models for other diseases including Severe Acute Respiratory Syndrome, fox rabies, and sexually transmitted infections are included as applications. Its chapters are coherent and complementary independent units. In order to accustom students to look at the current literature and to experience different perspectives, no attempt has been made to achieve united writing style or unified notation. Notes on some mathematical background (calculus, matrix algebra, differential equations, and probability) have been prepared and may be downloaded at the web site of the Centre for Disease Modeling (www.cdm.yorku.ca).
Precision Medicine And Artificial Intelligence
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Author : Michael Mahler
language : en
Publisher: Academic Press
Release Date : 2021-03-12
Precision Medicine And Artificial Intelligence written by Michael Mahler and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-12 with Science categories.
Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine