Computational Methods In Drug Discovery And Repurposing For Cancer Therapy
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Computational Methods In Drug Discovery And Repurposing For Cancer Therapy
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Author : Ganji Purnachandra Nagaraju
language : en
Publisher: Elsevier
Release Date : 2023-03-22
Computational Methods In Drug Discovery And Repurposing For Cancer Therapy written by Ganji Purnachandra Nagaraju and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-22 with Computers categories.
Computational Methods in Drug Discovery and Repurposing for Cancer Therapy provides knowledge about ongoing research as well as computational approaches for drug discovery and repurposing for cancer therapy. The book also provides detailed descriptions about target molecules, pathways, and their inhibitors for easy understanding and applicability. The book discusses tools and techniques such as integrated bioinformatics approaches, systems biology tools, molecular docking, computational chemistry, artificial intelligence, machine learning, structure-based virtual screening, biomarkers, and transcriptome; those are discussed in the context of different cancer types, such as colon, pancreatic, glioblastoma, endometrial, and retinoblastoma, among others. This book is a valuable resource for researchers, students, and members of the biomedical and medical fields who want to learn more about the use of computational modeling to better tailor the treatment for cancer patients. - Discusses in silico remodeling of effective phytochemical compounds for discovering improved anticancer agents for substantial/significant cancer therapy - Covers potential tools of bioinformatics that are applied toward discovering new targets by drug repurposing and strategies to cure different types of cancers - Demonstrates the significance of computational and artificial intelligence approaches in anticancer drug discovery - Explores how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care
Drug Repurposing In Cancer Therapy
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Author : Kenneth K.W. To
language : en
Publisher: Academic Press
Release Date : 2020-07-29
Drug Repurposing In Cancer Therapy written by Kenneth K.W. To and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-29 with Science categories.
Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. - Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research - Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences - Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types
Drug Repurposing
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Author : Farid A. Badria
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-12-02
Drug Repurposing written by Farid A. Badria and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-02 with Medical categories.
Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.
Molecular Modeling And Docking Techniques For Drug Discovery And Design
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Author : Bhat, Ajmal Rashid
language : en
Publisher: IGI Global
Release Date : 2025-02-05
Molecular Modeling And Docking Techniques For Drug Discovery And Design written by Bhat, Ajmal Rashid and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-05 with Medical categories.
In the realm of pharmaceutical research, the challenge of efficiently discovering and designing new drugs to combat diseases is ever-present. Traditional approaches to drug discovery often rely on time-consuming and costly experimental methods, leading to lengthy development timelines and high failure rates. This problem is exacerbated by the complexity of molecular interactions and the vast chemical space to explore. As a result, there is a pressing need for innovative solutions that can streamline the drug discovery process and improve its success rate. Molecular Modeling and Docking Techniques for Drug Discovery and Design addresses this critical challenge by offering a comprehensive guide to advanced computational methods in pharmaceutical research. Edited by leading experts in the field, the book provides insights into molecular modeling, docking, and other computational approaches that can significantly accelerate the drug discovery process. By leveraging computational tools and software, researchers can simulate molecular interactions, predict drug efficacy, and optimize chemical structures with greater speed and accuracy than traditional experimental methods.
Bioinformatics Essentials
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Author : Syed Mudasir Ahmad
language : en
Publisher: Academic Press
Release Date : 2025-07-01
Bioinformatics Essentials written by Syed Mudasir Ahmad and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-01 with Science categories.
Encompassing the foundational principles to advanced methodologies, Bioinformatics Essentials: Core Principles and Techniques offers a panoramic view of bioinformatics. It embarks on a journey that spans genes and genomes, sequence analysis, comparative genomics, functional genomics, and the exciting domain of protein structures and drug design. Spread over 3 parts and 7 chapters, the book describes the basic concepts in bioinformatics, genomic analysis, and ligand-based and structure-based drug designs. Each chapter is imbued with real-world context, demonstrating the practical implications of bioinformatics. Case studies, examples, and hands-on guides bridge the gap between theory and application, enabling readers to translate knowledge into tangible results. It fosters a holistic understanding of bioinformatics as an interdisciplinary field, acknowledges the evolving nature of bioinformatics, and prepares the readers for the future. Discussions on emerging trends, cutting-edge tools, and potential directions in the field of bioinformatics equip readers to stay at the forefront of advancements. Insights from both biology and computational science converge to provide a well-rounded perspective on the complex biological systems. While designed as a comprehensive guide for learners, the book also serves as a valuable reference for professionals seeking to deepen their understanding, refine their skills, and explore new avenues within bioinformatics. - Addresses fundamental concepts in bioinformatics - Equips nonbioinformaticians with the essential tools and knowledge required to conduct and plan experiments effectively - Includes command sets and test datasets, completed with sample results/outputs, serving as valuable resources for training purposes - Provides detailed tutorials on how to install these tools, along with troubleshooting guidance to address potential installation challenges
Drug Delivery Landscape In Cancer Research
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Author : Ranjita Shegokar
language : en
Publisher: Elsevier
Release Date : 2025-04-03
Drug Delivery Landscape In Cancer Research written by Ranjita Shegokar and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-03 with Science categories.
Drug Delivery Landscape in Cancer Research examines the combined impact of prevention, diagnosis, and treatment of cancer. With a strong focus on the status, challenges, and prospects of cancer drug delivery technology, the book examines clinical translation-related knowledge and the development of different organ related cancers. In 22 chapters, it describes current and new drug delivery systems in twenty different cancers and gives insights into drug delivery strategies and tumor microenvironment management in oral and ocular cancers. This book is a timely and valuable resource for health professionals, scientists, researchers, health practitioners, students, and anyone who wants to broaden their knowledge. - Contains current studies of the targeted use of drug delivery systems based on the microenvironmental properties of different cancer types - Provides essential information on the most recent drug delivery systems available for different cancer types - Explains current technology and its applications to drug delivery in cancer - Contains contributions from oncologists, biomedical engineers, pharmaceutical scientists, and manufacturers
Biosimilars For Cancer Treatment
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Author : Shvetank Bhatt
language : en
Publisher: Springer Nature
Release Date : 2024-07-01
Biosimilars For Cancer Treatment written by Shvetank Bhatt and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-01 with Medical categories.
The book delves into the role of biosimilars in the field of cancer treatment. It also discusses the application of biosimilars in various cancer types, from colorectal and cervical to prostate, gastric, lung, pancreatic, breast, hepatocellular, ovarian, and blood cancers. It contains chapters that focus on the clinical trials of biosimilars, providing insights into the latest research and developments. This book serves as a valuable resource for clinicians, researchers, and anyone seeking a comprehensive understanding of the intersection between biosimilars and cancer treatment.
Drug Repurposing And Computational Drug Discovery
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Author : Mithun Rudrapal
language : en
Publisher: CRC Press
Release Date : 2023-10-27
Drug Repurposing And Computational Drug Discovery written by Mithun Rudrapal and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-27 with Medical categories.
Drug repurposing is defined as identifying new pharmacological indications from old, existing, failed, investigational, already marketed, or FDA-approved drugs and prodrugs, and applying these new uses in the treatment of diseases other than the drug’s original intended therapeutic use. The application of computational techniques in discovery research not only helps in the development of drugs from leads or existing drug molecules but can also be useful for the repurposing of existing drug candidates. This new volume presents exciting recent advances in drug repurposing and computational approaches for the discovery and development of drugs against certain difficult-to-treat and life-threatening diseases. With contributions from a global team of experts (academicians, scientists, and researchers), it explores the sophisticated tools and techniques of drug repurposing and computational drug discovery. It delivers valuable information on computational techniques, tools, and databases being utilized for drug repurposing and for identifying the uses of existing drug candidates on different emerging or deadly diseases. Drug repurposing and computational approaches addressed in the book target the discovery and development of drugs for microbial infections (bacterial, fungal, viral, COVID-19), parasitic diseases and neglected tropical diseases (NTDs), malignant diseases (cancer), inflammatory diseases, cardiovascular disorders, diabetes, and aging and neurological (CNS) disorders. In addition, the challenges and regulatory issues encountered in drug repurposing and computational drug discovery programs are looked at, offering perspectives for future directions.
Machine Learning For Neurodegenerative Disorders
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Author : Biswajit Jena
language : en
Publisher: CRC Press
Release Date : 2025-03-31
Machine Learning For Neurodegenerative Disorders written by Biswajit Jena and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-31 with Science categories.
This book explores the application of machine learning to the understanding, early diagnosis, and management of neurodegenerative disorders. With a specific focus on its role in ongoing clinical trials, the book covers essential topics such as data collection, pre-processing, feature extraction, model development, and validation techniques. It delves into the applications of neuroimaging techniques like magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) in the diagnosis and understanding of neurodegenerative disorders. Additionally, the book examines various machine-learning algorithms employed for biomarker discovery in neurodegenerative disorders. It highlights the role of neuroinformatics and big data analysis in advancing the understanding and management of neurodegenerative disorders. Furthermore, the book reviews future prospects and presents the ethical considerations and regulatory challenges associated with implementing machine learning approaches in the diagnosis, treatment, and prevention of neurodegenerative disorders. This comprehensive resource is intended for neuroscientists, students, researchers, and neurologists to understand the emerging scope of machine learning in neurodegenerative disorders.
Phytochemistry Computational Tools And Databases In Drug Discovery
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Author : Chukwuebuka Egbuna
language : en
Publisher: Elsevier
Release Date : 2022-11-30
Phytochemistry Computational Tools And Databases In Drug Discovery written by Chukwuebuka Egbuna and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Science categories.
Phytochemistry, Computational Tools and Databases in Drug Discovery presents the state-of-the-art in computational methods and techniques for drug discovery studies from medicinal plants. Various tools and databases for virtual screening and characterization of plant bioactive compounds and their subsequent predictions on biological targets for the discovery of new drugs against specific diseases are presented, along with computational tools for the prediction of the toxic effects of phytochemicals on living systems. The book also provides in-depth insight on the applications of these computational tools as well as the databases that describe the interactions of phytochemicals with diseases along with predictions for druggable bioactive compounds. Useful for drug developers, medicinal chemists, toxicologists, phytochemists, plant biochemists and analytical chemists, this book clearly presents the various computational techniques, tools and databases for phytochemical research. - Provides the various databases, methods and procedures for computational drug discovery in plants - Includes insights into the predictors for properties of phytochemicals against different diseases - Discusses the applications of computational tools and their databases