Computational Modeling Of Patient Specific Cardiac Mechanics With Model Reduction Based Parameter Estimation And Applications To Novel Heart Assist Technologies
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Computational Modeling Of Patient Specific Cardiac Mechanics With Model Reduction Based Parameter Estimation And Applications To Novel Heart Assist Technologies
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Author : Marc Hirschvogel
language : en
Publisher:
Release Date : 2019
Computational Modeling Of Patient Specific Cardiac Mechanics With Model Reduction Based Parameter Estimation And Applications To Novel Heart Assist Technologies written by Marc Hirschvogel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Artificial Intelligence For Computational Modeling Of The Heart
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Author : Tommaso Mansi
language : en
Publisher: Academic Press
Release Date : 2019-12
Artificial Intelligence For Computational Modeling Of The Heart written by Tommaso Mansi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12 with Science categories.
Artificial Intelligence for Computational Modeling of the Heart presents recent research developments towards streamlined and automatic estimation of the digital twin of a patient's heart by combining computational modeling of heart physiology and artificial intelligence. The book first introduces the major aspects of multi-scale modeling of the heart, along with the compromises needed to achieve subject-specific simulations. Reader will then learn how AI technologies can unlock robust estimations of cardiac anatomy, obtain meta-models for real-time biophysical computations, and estimate model parameters from routine clinical data. Concepts are all illustrated through concrete clinical applications. Presents recent advances in computational modeling of heart function and artificial intelligence technologies for subject-specific applications Discusses AI-based technologies for robust anatomical modeling from medical images, data-driven reduction of multi-scale cardiac models, and estimations of physiological parameters from clinical data Illustrates the technology through concrete clinical applications and discusses potential impacts and next steps needed for clinical translation
Patient Specific Hemodynamic Computations Application To Personalized Diagnosis Of Cardiovascular Pathologies
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Author : Lucian Mihai Itu
language : en
Publisher: Springer
Release Date : 2017-05-31
Patient Specific Hemodynamic Computations Application To Personalized Diagnosis Of Cardiovascular Pathologies written by Lucian Mihai Itu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-31 with Medical categories.
Hemodynamic computations represent a state-of-the-art approach for patient-specific assessment of cardiovascular pathologies. The book presents the development of reduced-order multiscale hemodynamic models for coronary artery disease, aortic coarctation and whole body circulation, which can be applied in routine clinical settings for personalized diagnosis. Specific parameter estimation frameworks are introduced for calibrating the parameters of the models and high performance computing solutions are employed to reduce their execution time. The personalized computational models are validated against patient-specific measurements. The book is written for scientists in the field of biomedical engineering focusing on the cardiovascular system, as well as for research-oriented physicians in cardiology and industrial players in the field of healthcare technologies.
Computational Cardiovascular Mechanics
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Author : Julius M. Guccione
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-01-08
Computational Cardiovascular Mechanics written by Julius M. Guccione and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-08 with Technology & Engineering categories.
Computational Cardiovascular Mechanics provides a cohesive guide to creating mathematical models for the mechanics of diseased hearts to simulate the effects of current treatments for heart failure. Clearly organized in a two part structure, this volume discusses various areas of computational modeling of cardiovascular mechanics (finite element modeling of ventricular mechanics, fluid dynamics) in addition to a description an analysis of the current applications used (solid FE modeling, CFD). Edited by experts in the field, researchers involved with biomedical and mechanical engineering will find Computational Cardiovascular Mechanics a valuable reference.
Patient Specific Modeling Of The Cardiovascular System
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Author : Roy C.P. Kerckhoffs
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-03
Patient Specific Modeling Of The Cardiovascular System written by Roy C.P. Kerckhoffs and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-03 with Science categories.
Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.
Patient Specific Modeling Of The Cardiovascular System
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Author :
language : en
Publisher:
Release Date : 2011-07-11
Patient Specific Modeling Of The Cardiovascular System written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-11 with categories.
Mathematical Modelling Of The Human Cardiovascular System
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Author : Alfio Quarteroni
language : en
Publisher: Cambridge University Press
Release Date : 2019-05-09
Mathematical Modelling Of The Human Cardiovascular System written by Alfio Quarteroni and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-09 with Mathematics categories.
Addresses the mathematical and numerical modelling of the human cardiovascular system, from patient data to clinical applications.
Statistical Atlases And Computational Models Of The Heart Imaging And Modelling Challenges
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Author : Oscar Camara
language : en
Publisher: Springer
Release Date : 2014-12-31
Statistical Atlases And Computational Models Of The Heart Imaging And Modelling Challenges written by Oscar Camara and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-31 with Computers categories.
This book constitutes the thoroughly refereed post-conference proceedings of the 5th International Workshop on Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges, STACOM 2014, held in conjunction with MICCAI 2014, in Boston, MA, USA, in September 2014. The 30 revised full papers were carefully reviewed and selected from numerous submissions. The papers cover a wide range of topics such as sections on cardiac image processing; atlas construction; statistical modelling of cardiac function across different patient populations; cardiac mapping; cardiac computational physiology; model customization; atlas based functional analysis; ontological schemata for data and results; integrated functional and structural analyses; as well as the pre-clinical and clinical applicability of these methods.
Computational And Mathematical Methods In Cardiovascular Physiology
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Author : Liang Zhong
language : en
Publisher: World Scientific
Release Date : 2019-04-26
Computational And Mathematical Methods In Cardiovascular Physiology written by Liang Zhong and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-26 with Medical categories.
Cardiovascular diseases (CVD) including heart diseases, peripheral vascular disease and heart failure, account for one-third of deaths throughout the world. CVD risk factors include systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, and diabetic status. Clinical trials have demonstrated that when modifiable risk factors are treated and corrected, the chances of CVD occurring can be reduced. This illustrates the importance of this book's elaborate coverage of cardiovascular physiology by the application of mathematical and computational methods.This book has literally transformed Cardiovascular Physiology into a STEM discipline, involving (i) quantitative formulations of heart anatomy and physiology, (ii) technologies for imaging the heart and blood vessels, (iii) coronary stenosis hemodynamics measure by means of fractional flow reserve and intervention by grafting and stenting, (iv) fluid mechanics and computational analysis of blood flow in the heart, aorta and coronary arteries, and (v) design of heart valves, percutaneous valve stents, and ventricular assist devices.So how is this mathematically and computationally configured landscape going to impact cardiology and even cardiac surgery? We are now entering a new era of mathematical formulations of anatomy and physiology, leading to technological formulations of medical and surgical procedures towards more precise medicine and surgery. This will entail reformatting of (i) the medical MD curriculum and courses, so as to educate and train a new generation of physicians who are conversant with medical technologies for applying into clinical care, as well as (ii) structuring of MD-PhD (Computational Medicine and Surgery) Program, to train competent medical and surgical specialists in precision medical care and patient-specific surgical care.This book provides a gateway for this new emerging scenario of (i) science and engineering based medical educational curriculum, and (ii) technologically oriented medical and surgical procedures. As such, this book can be usefully employed as a textbook for courses in (i) cardiovascular physiology in both the schools of engineering and medicine of universities, as well as (ii) cardiovascular engineering in biomedical engineering departments worldwide.
Computational Modeling Of Cardiac Mechanics
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Author : Ce Xi
language : en
Publisher:
Release Date : 2019
Computational Modeling Of Cardiac Mechanics written by Ce Xi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic dissertations categories.
Heart diseases, which approximately account for 31% of all human mortality every year, are the leading cause of death worldwide. Computational cardiac models have gained increasing popularity and become an indispensable and powerful tool in elucidating the pathological process of different heart diseases. They can be used to estimate important physiological and clinically relevant quantities that are difficult to directly measure in experiments. The broad goals of this thesis were to develop 1) a microstructure-based constitutive model of the heart and 2) patient-specific computational models that would ultimately help medical scientists to diagnose and treat heart diseases.Heart diseases such as heart failure with preserved ejection fraction (HFpEF) are characterized by abnormalities of ventricular function that can be attributed to, changes in geometry, impaired myocyte (LV) relaxation, cardiac fibrosis and myocyte passive stiffening. Understanding how LV filling is affected by each of the many microstructural pathological features in heart diseases is very important and may help in the development of appropriate treatments. To address this need, we have developed and validated a microstructure-based computational model of the myocardium to investigate the role of tissue constituents and their ultrastructure in affecting the heart function. The model predicted that the LV filling function is sensitive to the collagen ultrastructure and the load taken up by the tissue constituents varies depending on the LV transmural location. This finding may have implications in the development of new pharmaceutical treatments targeting individual cardiac tissue constituents to normalize LV filling function in HFpEF.Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by elevated pulmonary artery pressure (PAP) and pulmonary artery vascular resistance, with limited survival rate and can affect patients of all ages. The increased pressure or afterload in the right ventricle (RV) can result in pathological changes in RV mechanics, which are currently not well-understood. To fill this void, we have developed patient-specific computational models to investigate effects of PAH on ventricular mechanics. Specifically, we have quantified regional ventricular myofiber stress, myofiber strain, contractility, and passive tissue stiffness in PAH patients, and compare them to those found in age- and gender-matched normal controls. Our results showed that RV longitudinal, circumferential and radial strain were depressed in PAH patients compared with controls; RV passive stiffness increased progressively with the degree of remodeling as indexed by the RV and LV end-diastolic volume ratio (RVEDV/LVEDV); Peak contractility of the RV was found to be strongly correlated, and had an inverse relationship with RVEDV/LVEDV. These results provide the mechanical basis of using RVEDV/LVEDV as a clinical index for delineating disease severity and estimating RVFW contractility in PAH patients.