Patient Specific Modeling Of The Cardiovascular System
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Patient Specific Modeling Of The Cardiovascular System
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Author : Roy C.P. Kerckhoffs
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-03
Patient Specific Modeling Of The Cardiovascular System written by Roy C.P. Kerckhoffs and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-03 with Science categories.
Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.
Patient Specific Modeling Of The Cardiovascular System
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Author : Roy C.P. Kerckhoffs
language : en
Publisher: Springer
Release Date : 2010-09-09
Patient Specific Modeling Of The Cardiovascular System written by Roy C.P. Kerckhoffs and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-09 with Science categories.
Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.
Mathematical Modelling Of The Human Cardiovascular System
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Author : Alfio Quarteroni
language : en
Publisher: Cambridge University Press
Release Date : 2019-05-09
Mathematical Modelling Of The Human Cardiovascular System written by Alfio Quarteroni and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-09 with Mathematics categories.
Addresses the mathematical and numerical modelling of the human cardiovascular system, from patient data to clinical applications.
Patient Specific Hemodynamic Computations Application To Personalized Diagnosis Of Cardiovascular Pathologies
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Author : Lucian Mihai Itu
language : en
Publisher: Springer
Release Date : 2017-05-31
Patient Specific Hemodynamic Computations Application To Personalized Diagnosis Of Cardiovascular Pathologies written by Lucian Mihai Itu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-31 with Medical categories.
Hemodynamic computations represent a state-of-the-art approach for patient-specific assessment of cardiovascular pathologies. The book presents the development of reduced-order multiscale hemodynamic models for coronary artery disease, aortic coarctation and whole body circulation, which can be applied in routine clinical settings for personalized diagnosis. Specific parameter estimation frameworks are introduced for calibrating the parameters of the models and high performance computing solutions are employed to reduce their execution time. The personalized computational models are validated against patient-specific measurements. The book is written for scientists in the field of biomedical engineering focusing on the cardiovascular system, as well as for research-oriented physicians in cardiology and industrial players in the field of healthcare technologies.
Multiscale And Patient Specific Cardiovascular Modeling
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Author : Daniel Joseph Canuto
language : en
Publisher:
Release Date : 2019
Multiscale And Patient Specific Cardiovascular Modeling written by Daniel Joseph Canuto and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Despite continuing advances in computational power, full-body models of the human cardiovascular system remain a costly task. Two principal reasons for this cost are the total overall length of the vascular network (spanning O(10^8) m) and the broad range of length scales (from 10^ 2 to 10^ 6 m) involved. Multiscale modeling can be employed to overcome these issues; specifically, subsystems of higher spatial dimension representing domains of interest can be coupled at their boundaries to lower-dimensional subsystems that mimic relevant inflow/outflow conditions. Though this scheme can increase computational efficiency, the inherent reduction in spatial dimension results in parameterizations that can be difficult to optimize in patient-specific contexts. This work is divided into two parts: in the first segment, a closed-loop multiscale model of the entire cardiovascular system is developed and integrated with a feedback control model for blood pressure regulation. It is tested against clinical data for cohorts of healthy subjects, and its predictive utility is demonstrated in a simulation of acute hemorrhage from the upper leg. After validating the multiscale/reduced-order approach, a parameter optimization technique based on the ensemble Kalman filter (EnKF) is constructed. By assimilating patients' clinical measurements, this method is shown to successfully tune parameters in two models: a zero-dimensional model of the pulmonary circulation, and a multiscale 0D-1D model of the lower leg.
Mathematical And Numerical Modeling Of The Cardiovascular System And Applications
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Author : Daniele Boffi
language : en
Publisher: Springer
Release Date : 2018-11-03
Mathematical And Numerical Modeling Of The Cardiovascular System And Applications written by Daniele Boffi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-03 with Mathematics categories.
The book comprises contributions by some of the most respected scientists in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. It covers a wide range of topics, from the assimilation of clinical data to the development of mathematical and computational models, including with parameters, as well as their efficient numerical solution, and both in-vivo and in-vitro validation. It also considers applications of relevant clinical interest. This book is intended for graduate students and researchers in the field of bioengineering, applied mathematics, computer, computational and data science, and medicine wishing to become involved in the highly fascinating task of modeling the cardiovascular system.
Patient Specific Computational Modeling
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Author : Begoña Calvo Lopez
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-05-20
Patient Specific Computational Modeling written by Begoña Calvo Lopez and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-20 with Technology & Engineering categories.
This book addresses patient-specific modeling. It integrates computational modeling, experimental procedures, imagine clinical segmentation and mesh generation with the finite element method (FEM) to solve problems in computational biomedicine and bioengineering. Specific areas of interest include cardiovascular problems, ocular and muscular systems and soft tissue modeling. Patient-specific modeling has been the subject of serious research over the last seven years and interest in the area is continually growing and this area is expected to further develop in the near future.
Patient Specific Modeling And Quantification Of The Heart Valves From Multimodal Cardiac Images
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Author : Razvan Ioan Ionasec
language : en
Publisher:
Release Date : 2010
Patient Specific Modeling And Quantification Of The Heart Valves From Multimodal Cardiac Images written by Razvan Ioan Ionasec and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
3 Dimensional Modeling In Cardiovascular Disease
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Author : Evan M. Zahn
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-09-14
3 Dimensional Modeling In Cardiovascular Disease written by Evan M. Zahn and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-14 with Medical categories.
Written by physicians and surgeons, imaging specialists, and medical technology engineers, and edited by Dr. Evan M. Zahn of the renowned Cedars-Sinai Heart Institute, this concise, focused volume covers must-know information in this new and exciting field. Covering everything from the evolution of 3D modeling in cardiac disease to the various roles of 3D modeling in cardiology to cardiac holography and 3D bioprinting, 3-Dimensional Modeling in Cardiovascular Disease is a one-stop resource for physicians, cardiologists, radiologists, and engineers who work with patients, support care providers, and perform research. Provides history and context for the use of 3D printing in cardiology settings, discusses how to use it to plan and evaluate treatment, explains how it can be used as an education resource, and explores its effectiveness with medical interventions. Presents specific uses for 3D modeling of the heart, examines whether it improves outcomes, and explores 3D bioprinting. Consolidates today’s available information and guidance into a single, convenient resource.
Mathematical Modeling And Validation In Physiology
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Author : Jerry J. Batzel
language : en
Publisher: Springer
Release Date : 2012-12-14
Mathematical Modeling And Validation In Physiology written by Jerry J. Batzel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-14 with Mathematics categories.
This volume synthesizes theoretical and practical aspects of both the mathematical and life science viewpoints needed for modeling of the cardiovascular-respiratory system specifically and physiological systems generally. Theoretical points include model design, model complexity and validation in the light of available data, as well as control theory approaches to feedback delay and Kalman filter applications to parameter identification. State of the art approaches using parameter sensitivity are discussed for enhancing model identifiability through joint analysis of model structure and data. Practical examples illustrate model development at various levels of complexity based on given physiological information. The sensitivity-based approaches for examining model identifiability are illustrated by means of specific modeling examples. The themes presented address the current problem of patient-specific model adaptation in the clinical setting, where data is typically limited.