Computational Neuropharmacology
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Computational Neuropharmacology
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Author : Bhupendra Prajapati
language : en
Publisher: John Wiley & Sons
Release Date : 2025-06-04
Computational Neuropharmacology written by Bhupendra Prajapati and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-04 with Science categories.
The book gives comprehensive insights into the cutting-edge intersection of computational methods and neuropharmacology, making it an essential resource for understanding and advancing medication for neurological and psychiatric disorders. Computational Neuropharmacology is an in-depth exploration of the convergence of computational methods with neuropharmacology, a science concerned with understanding pharmacological effects on the nervous system. This volume explores the most recent breakthroughs and potential advances in computational neuropharmacology, providing an extensive overview of the computational tools that are transforming medication discovery and development for neurological and psychiatric illnesses. Fundamental principles of computational neuropharmacology, descriptions of molecular-level interactions and their consequences for modern neuropharmacology, and an introduction to theoretical neuroscience are highlighted throughout this resource. Additionally, this study addresses computational attitudes in counseling psychology to improve therapeutic procedures through data-driven insights. Computational psychiatry uses computational technologies to bridge the gap between the molecular basis and clinical symptoms of psychiatric diseases. This volume covers computational approaches to drug discovery in neurohumoral transmission and signal transduction, Parkinson’s disease, epilepsy, and Alzheimer’s disease, and the use of molecular docking and machine learning in drug development for neurological disorders. It also discusses the use of computational methods to uncover potential treatments for autism spectrum disorder, depression, and anxiety. Audience This book is a valuable resource for computer scientists, engineers, researchers, clinicians, and students, providing a detailed understanding of the computational tools that are changing the developing field of neuropharmacology, leading the future of medication discovery and development for neurological and psychiatric illnesses by combining modern computational approaches with neuropharmacological research.
Validating Neuro Computational Models Of Neurological And Psychiatric Disorders
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Author : Basabdatta Sen Bhattacharya
language : en
Publisher: Springer
Release Date : 2015-10-30
Validating Neuro Computational Models Of Neurological And Psychiatric Disorders written by Basabdatta Sen Bhattacharya and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-30 with Medical categories.
This book is a collection of articles by leading researchers working at the cutting edge of neuro-computational modelling of neurological and psychiatric disorders. Each article contains model validation techniques used in the context of the specific problem being studied. Validation is essential for neuro-inspired computational models to become useful tools in the understanding and treatment of disease conditions. Currently, the immense diversity in neuro-computational modelling approaches for investigating brain diseases has created the need for a structured and coordinated approach to benchmark and standardise validation methods and techniques in this field of research. This book serves as a step towards a systematic approach to validation of neuro-computational models used for studying brain diseases and should be useful for all neuro-computational modellers.
Advanced Computational Approaches To Biomedical Engineering
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Author : Punam K. Saha
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-01-23
Advanced Computational Approaches To Biomedical Engineering written by Punam K. Saha and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-23 with Computers categories.
There has been rapid growth in biomedical engineering in recent decades, given advancements in medical imaging and physiological modelling and sensing systems, coupled with immense growth in computational and network technology, analytic approaches, visualization and virtual-reality, man-machine interaction and automation. Biomedical engineering involves applying engineering principles to the medical and biological sciences and it comprises several topics including biomedicine, medical imaging, physiological modelling and sensing, instrumentation, real-time systems, automation and control, signal processing, image reconstruction, processing and analysis, pattern recognition, and biomechanics. It holds great promise for the diagnosis and treatment of complex medical conditions, in particular, as we can now target direct clinical applications, research and development in biomedical engineering is helping us to develop innovative implants and prosthetics, create new medical imaging technologies and improve tools and techniques for the detection, prevention and treatment of diseases. The contributing authors in this edited book present representative surveys of advances in their respective fields, focusing in particular on techniques for the analysis of complex biomedical data. The book will be a useful reference for graduate students, researchers and industrial practitioners in computer science, biomedical engineering, and computational and molecular biology.
Computational Neurology And Psychiatry
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Author : Péter Érdi
language : en
Publisher: Springer
Release Date : 2017-01-25
Computational Neurology And Psychiatry written by Péter Érdi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-25 with Technology & Engineering categories.
This book presents the latest research in computational methods for modeling and simulating brain disorders. In particular, it shows how mathematical models can be used to study the relationship between a given disorder and the specific brain structure associated with that disorder. It also describes the emerging field of computational psychiatry, including the study of pathological behavior due to impaired functional connectivity, pathophysiological activity, and/or aberrant decision-making. Further, it discusses the data analysis techniques that will be required to analyze the increasing amount of data being generated about the brain. Lastly, the book offers some tips on the application of computational models in the field of quantitative systems pharmacology. Mainly written for computational scientists eager to discover new application fields for their model, this book also benefits neurologists and psychiatrists wanting to learn about new methods.
Complexity Explained
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Author : Peter Erdi
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-09
Complexity Explained written by Peter Erdi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-09 with Technology & Engineering categories.
This book is, of course about complexity. The title of the book, as you may recognize was motivated (excuse me for using this very mild expression) by Daniel Dennett’s Consciousness Explained [130]. Dennett’s intention was to explain consciousness as the emergent product of the interaction among c- stituents having physical and neural character. The goal of this book is to explain how various types of complexity emerge due to the interaction among constituents. There are many questions to be answered, how to understand, control, decompose, manage, predict the many-faced complexity. After tea- ing thissubjectforseveralyearsIfeelthatthe time hascome toputthe whole story together. The term “complex system” is a buzzword, but we certainly don’t have a single de?nition for it. There are several predominant features of compl- ity. Complex processes may show unpredictable behavior (which we still try to predict somehow), may lead to uncontrolled explosion (such in case of epilepsy, earthquake eruptions or stock market crashes). One of the char- teristic feature of simple systems is, that there is a single cause which implies a single e?ect. For large class of complex systems it is true that e?ects are fed back to modify causes. Biological cells belong to this class. Furthermore they are open to material, energetic and information ?ow by interaction with their environment, still they are organizationallyclosed units. Another aspect of complexity is the question how collective phenomena emerge by some se- organized mechanisms.
The Emerging Discipline Of Quantitative Systems Pharmacology
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Author : Tarek A. Leil
language : en
Publisher: Frontiers Media SA
Release Date : 2015-09-07
The Emerging Discipline Of Quantitative Systems Pharmacology written by Tarek A. Leil and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-07 with Biology categories.
In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems Biology” and “Quantitative Pharmacology”. Systems Biology is the field of biomedical research that seeks to understand the relationships between genes and biologically active molecules to develop qualitative models of these systems; and Quantitative Pharmacology is the field of biomedical research that seeks to use computer aided modeling and simulation to increase our understanding of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, and to aid in the design of pre-clinical and clinical experiments. The purpose of QSP modeling is to develop quantitative computer models of biological systems and disease processes, and the effects of drug PK and PD on those systems. QSP models allow testing of numerous potential experiments “in-silico” to eliminate those associated with a low probability of success, avoiding the potential costs of evaluating all of those failed experiments in the real world. At the same time, QSP models allow us to develop our understanding of the interaction between drugs and biological systems in a more systematic and rigorous manner. As the need to be more cost-efficient in the use of research funding increases, biomedical researchers will be required to gain the maximum insight from each experiment that is conducted. This need is even more acute in the pharmaceutical industry, where there is tremendous competition to develop innovative therapies in a highly regulated environment, combined with very high research and development (R&D) costs for bringing new drugs to market (~$1.3 billion/drug). Analogous modeling & simulation approaches have been successfully integrated into other disciplines to improve the fundamental understanding of the science and to improve the efficiency of R&D (e.g., physics, engineering, economics, etc.). The biomedical research community has been slow to integrate computer aided modeling & simulation for many reasons: including the perception that biology and pharmacology are “too complex” and “too variable” to be modeled with mathematical equations; a lack of adequate graduate training programs; and the lack of support from government agencies that fund biomedical research. However, there is an active community of researchers in the pharmaceutical industry, the academic community, and government agencies that develop QSP and quantitative systems biology models and apply them both to better characterize and predict drug pharmacology and disease processes; as well as to improve efficiency and productivity in pharmaceutical R&D.
Computational Models Of Brain And Behavior
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Author : Ahmed A. Moustafa
language : en
Publisher: John Wiley & Sons
Release Date : 2017-09-11
Computational Models Of Brain And Behavior written by Ahmed A. Moustafa and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-11 with Psychology categories.
A comprehensive Introduction to the world of brain and behavior computational models This book provides a broad collection of articles covering different aspects of computational modeling efforts in psychology and neuroscience. Specifically, it discusses models that span different brain regions (hippocampus, amygdala, basal ganglia, visual cortex), different species (humans, rats, fruit flies), and different modeling methods (neural network, Bayesian, reinforcement learning, data fitting, and Hodgkin-Huxley models, among others). Computational Models of Brain and Behavior is divided into four sections: (a) Models of brain disorders; (b) Neural models of behavioral processes; (c) Models of neural processes, brain regions and neurotransmitters, and (d) Neural modeling approaches. It provides in-depth coverage of models of psychiatric disorders, including depression, posttraumatic stress disorder (PTSD), schizophrenia, and dyslexia; models of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy; early sensory and perceptual processes; models of olfaction; higher/systems level models and low-level models; Pavlovian and instrumental conditioning; linking information theory to neurobiology; and more. Covers computational approximations to intellectual disability in down syndrome Discusses computational models of pharmacological and immunological treatment in Alzheimer's disease Examines neural circuit models of serotonergic system (from microcircuits to cognition) Educates on information theory, memory, prediction, and timing in associative learning Computational Models of Brain and Behavior is written for advanced undergraduate, Master's and PhD-level students—as well as researchers involved in computational neuroscience modeling research.
20 Years Of Computational Neuroscience
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Author : James M Bower
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-11
20 Years Of Computational Neuroscience written by James M Bower and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-11 with Medical categories.
When funding agencies and policy organizations consider the role of modeling and simulation in modern biology, the question is often posed, what has been accomplished ? This book will be organized around a symposium on the 20 year history of the CNS meetings, to be held as part of CNS 2010 in San Antonio Texas in July 2010. The book, like the symposium is intended to summarize progress made in Computational Neuroscience over the last 20 years while also considering current challenges in the field. As described in the table of contents, the chapter’s authors have been selected to provide wide coverage of the applications of computational techniques to a broad range of questions and model systems in neuroscience. The proposed book will include several features that establish the history of the field. For each article, its author will select an article originally appearing in a CNS conference proceedings from 15 – 20 years ago. These short (less than 6 page) articles will provide illustrations of the state of the field 20 years ago. The new articles will describe what has been learned about the subject in the following 20 years, and pose specific challenges for the next 20 years. The second historical mechanism will be the reproduction of the first 12 years of posters from the CNS meeting. These posters in and of themselves have become famous in the field (they hang in the halls of the NIH in Bethesda Maryland) and were constructed as allegories for the state and development of computational neuroscience. The posters were designed by the book’s editor, who will, for the first time, provide a written description of each poster.
The Amygdala
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Author : Barbara Ferry
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-12-19
The Amygdala written by Barbara Ferry and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-19 with Medical categories.
Among the components of the limbic system, the amygdala is a fascinating structure that is involved in the processes of liking and disliking and in the ways our emotions drive our actions and affect the strength of our memories. Combined with new conceptual breakthroughs, the very latest data obtained by leading world experts in amygdala function that are reviewed in this book have helped to understand how the amygdala contribute to these processes and also to a variety of neurological and neuropsychiatric pathologies. Of course, due to the rate of research advancement, all the chapters presented here correspond to precise questions addressed by experts using highly specific techniques. Therefore, each chapter should be viewed as pieces of a puzzle that represent all the different research areas that have to be taken into consideration in discussing the role of the amygdala in emotion and memory. Although the primary goal of this book is to inform experts and newcomers of some of the latest data in the field of brain structures involved in mechanisms underlying emotional learning and memory, we hope it will also help to stimulate discussion on the functional role of the amygdala and connected brain structures in these mechanisms.
Molecular Neuropharmacology
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Author : Arne Schousboe
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-12-22
Molecular Neuropharmacology written by Arne Schousboe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-22 with Medical categories.
A powerful collection of readily reproducible cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. By illuminating how neurons in the central nervous communicate with other, these techniques can lead to the development of novel therapeutic strategies for neurological diseases.