Computational Systems Neurobiology
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Computational Systems Neurobiology
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Author : N. Le Novère
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-20
Computational Systems Neurobiology written by N. Le Novère and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-20 with Medical categories.
Computational neurosciences and systems biology are among the main domains of life science research where mathematical modeling made a difference. This book introduces the many different types of computational studies one can develop to study neuronal systems. It is aimed at undergraduate students starting their research in computational neurobiology or more senior researchers who would like, or need, to move towards computational approaches. Based on their specific project, the readers would then move to one of the more specialized excellent textbooks available in the field. The first part of the book deals with molecular systems biology. Functional genomics is introduced through examples of transcriptomics and proteomics studies of neurobiological interest. Quantitative modelling of biochemical systems is presented in homogeneous compartments and using spatial descriptions. A second part deals with the various approaches to model single neuron physiology, and naturally moves to neuronal networks. A division is focused on the development of neurons and neuronal systems and the book closes on a series of methodological chapters. From the molecules to the organ, thinking at the level of systems is transforming biology and its impact on society. This book will help the reader to hop on the train directly in the tank engine.
Theoretical Neuroscience
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Author : Peter Dayan
language : en
Publisher: Mit Press
Release Date : 2001
Theoretical Neuroscience written by Peter Dayan and has been published by Mit Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Computers categories.
The construction and analysis of mathematical and computational models of neural systems.
Theoretical Neuroscience
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Author : Laurence F. Abbott
language : en
Publisher: MIT Press
Release Date : 2005-08-12
Theoretical Neuroscience written by Laurence F. Abbott and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-12 with Medical categories.
Theoretical neuroscience provides a quantitative basis for describing what nervous systems do, determining how they function, and uncovering the general principles by which they operate. This text introduces the basic mathematical and computational methods of theoretical neuroscience and presents applications in a variety of areas including vision, sensory-motor integration, development, learning, and memory. The book is divided into three parts. Part I discusses the relationship between sensory stimuli and neural responses, focusing on the representation of information by the spiking activity of neurons. Part II discusses the modeling of neurons and neural circuits on the basis of cellular and synaptic biophysics. Part III analyzes the role of plasticity in development and learning. An appendix covers the mathematical methods used, and exercises are available on the book's Web site.
Principles Of Computational Modelling In Neuroscience
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Author : David Sterratt
language : en
Publisher: Cambridge University Press
Release Date : 2011-06-30
Principles Of Computational Modelling In Neuroscience written by David Sterratt and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-30 with Medical categories.
The nervous system is made up of a large number of interacting elements. To understand how such a complex system functions requires the construction and analysis of computational models at many different levels. This book provides a step-by-step account of how to model the neuron and neural circuitry to understand the nervous system at all levels, from ion channels to networks. Starting with a simple model of the neuron as an electrical circuit, gradually more details are added to include the effects of neuronal morphology, synapses, ion channels and intracellular signalling. The principle of abstraction is explained through chapters on simplifying models, and how simplified models can be used in networks. This theme is continued in a final chapter on modelling the development of the nervous system. Requiring an elementary background in neuroscience and some high school mathematics, this textbook is an ideal basis for a course on computational neuroscience.
The Computational Neurobiology Of Reaching And Pointing
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Author : Reza Shadmehr
language : en
Publisher: MIT Press
Release Date : 2004-10-28
The Computational Neurobiology Of Reaching And Pointing written by Reza Shadmehr and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-10-28 with Medical categories.
An introduction to the computational biology of reaching and pointing, with an emphasis on motor learning. Neuroscience involves the study of the nervous system, and its topics range from genetics to inferential reasoning. At its heart, however, lies a search for understanding how the environment affects the nervous system and how the nervous system, in turn, empowers us to interact with and alter our environment. This empowerment requires motor learning. The Computational Neurobiology of Reaching and Pointing addresses the neural mechanisms of one important form of motor learning. The authors integrate material from the computational, behavioral, and neural sciences of motor control that is not available in any other single source. The result is a unified, comprehensive model of reaching and pointing. The book is intended to be used as a text by graduate students in both neuroscience and bioengineering and as a reference source by experts in neuroscience, robotics, and other disciplines. The book begins with an overview of the evolution, anatomy, and physiology of the motor system, including the mechanisms for generating force and maintaining limb stability. The sections that follow, "Computing Locations and Displacements", "Skills, Adaptations, and Trajectories", and "Predictions, Decisions, and Flexibility", present a theory of sensorially guided reaching and pointing that evolves organically based on computational principles rather than a traditional structure-by-structure approach. The book also includes five appendixes that provide brief refreshers on fundamentals of biology, mathematics, physics, and neurophysiology, as well as a glossary of relevant terms. The authors have also made supplemental materials available on the Internet. These web documents provide source code for simulations, step-by-step derivations of certain mathematical formulations, and expanded explanations of some concepts.
Computational Neuroscience
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Author : Jianfeng Feng
language : en
Publisher: Chapman and Hall/CRC
Release Date : 2003-10-20
Computational Neuroscience written by Jianfeng Feng and has been published by Chapman and Hall/CRC this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-20 with Science categories.
How does the brain work? After a century of research, we still lack a coherent view of how neurons process signals and control our activities. But as the field of computational neuroscience continues to evolve, we find that it provides a theoretical foundation and a set of technological approaches that can significantly enhance our understanding. Computational Neuroscience: A Comprehensive Approach provides a unified treatment of the mathematical theory of the nervous system and presents concrete examples demonstrating how computational techniques can illuminate difficult neuroscience problems. In chapters contributed by top researchers, the book introduces the basic mathematical concepts, then examines modeling at all levels, from single-channel and single neuron modeling to neuronal networks and system-level modeling. The emphasis is on models with close ties to experimental observations and data, and the authors review application of the models to systems such as olfactory bulbs, fly vision, and sensorymotor systems. Understanding the nature and limits of the strategies neural systems employ to process and transmit sensory information stands among the most exciting and difficult challenges faced by modern science. This book clearly shows how computational neuroscience has and will continue to help meet that challenge.
Emergent Neural Computational Architectures Based On Neuroscience
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Author : Stefan Wermter
language : en
Publisher: Springer
Release Date : 2003-05-15
Emergent Neural Computational Architectures Based On Neuroscience written by Stefan Wermter and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-05-15 with Computers categories.
It is generally understood that the present approachs to computing do not have the performance, flexibility, and reliability of biological information processing systems. Although there is a comprehensive body of knowledge regarding how information processing occurs in the brain and central nervous system this has had little impact on mainstream computing so far. This book presents a broad spectrum of current research into biologically inspired computational systems and thus contributes towards developing new computational approaches based on neuroscience. The 39 revised full papers by leading researchers were carefully selected and reviewed for inclusion in this anthology. Besides an introductory overview by the volume editors, the book offers topical parts on modular organization and robustness, timing and synchronization, and learning and memory storage.
Dynamical Systems In Neuroscience
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Author : Eugene M. Izhikevich
language : en
Publisher: MIT Press
Release Date : 2010-01-22
Dynamical Systems In Neuroscience written by Eugene M. Izhikevich and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-22 with Medical categories.
Explains the relationship of electrophysiology, nonlinear dynamics, and the computational properties of neurons, with each concept presented in terms of both neuroscience and mathematics and illustrated using geometrical intuition. In order to model neuronal behavior or to interpret the results of modeling studies, neuroscientists must call upon methods of nonlinear dynamics. This book offers an introduction to nonlinear dynamical systems theory for researchers and graduate students in neuroscience. It also provides an overview of neuroscience for mathematicians who want to learn the basic facts of electrophysiology. Dynamical Systems in Neuroscience presents a systematic study of the relationship of electrophysiology, nonlinear dynamics, and computational properties of neurons. It emphasizes that information processing in the brain depends not only on the electrophysiological properties of neurons but also on their dynamical properties. The book introduces dynamical systems, starting with one- and two-dimensional Hodgkin-Huxley-type models and continuing to a description of bursting systems. Each chapter proceeds from the simple to the complex, and provides sample problems at the end. The book explains all necessary mathematical concepts using geometrical intuition; it includes many figures and few equations, making it especially suitable for non-mathematicians. Each concept is presented in terms of both neuroscience and mathematics, providing a link between the two disciplines. Nonlinear dynamical systems theory is at the core of computational neuroscience research, but it is not a standard part of the graduate neuroscience curriculum—or taught by math or physics department in a way that is suitable for students of biology. This book offers neuroscience students and researchers a comprehensive account of concepts and methods increasingly used in computational neuroscience. An additional chapter on synchronization, with more advanced material, can be found at the author's website, www.izhikevich.com.
Encyclopedia Of Computational Neuroscience
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Author : Dieter Jäger
language : en
Publisher: Springer
Release Date : 2022-04-26
Encyclopedia Of Computational Neuroscience written by Dieter Jäger and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-26 with Medical categories.
The annual Computational Neuroscience Meeting (CNS) began in 1990 as a small workshop called Analysis and Modeling of Neural Systems. The goal of the workshop was to explore the boundary between neuroscience and computation. Riding on the success of several seminal papers, physicists had made "Neural Networks" fashionable, and soon the quantitative methods used in these abstract model networks started permeating the methods and ideas of experimental neuroscientists. Although experimental neurophysiological approaches provided many advances, it became increasingly evident that mathematical and computational techniques would be required to achieve a comprehensive and quantitative understanding of neural system function. “Computational Neuroscience” emerged to complement experimental neurophysiology. The Encyclopedia of Computational Neuroscience, published in conjunction with the Organization for Computational Neuroscience, will be an extensive reference work consultable by both researchers and graduate level students. It will be a dynamic, living reference, updatable and containing linkouts and multimedia content whenever relevant.
20 Years Of Computational Neuroscience
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Author : James M Bower
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-11
20 Years Of Computational Neuroscience written by James M Bower and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-11 with Medical categories.
When funding agencies and policy organizations consider the role of modeling and simulation in modern biology, the question is often posed, what has been accomplished ? This book will be organized around a symposium on the 20 year history of the CNS meetings, to be held as part of CNS 2010 in San Antonio Texas in July 2010. The book, like the symposium is intended to summarize progress made in Computational Neuroscience over the last 20 years while also considering current challenges in the field. As described in the table of contents, the chapter’s authors have been selected to provide wide coverage of the applications of computational techniques to a broad range of questions and model systems in neuroscience. The proposed book will include several features that establish the history of the field. For each article, its author will select an article originally appearing in a CNS conference proceedings from 15 – 20 years ago. These short (less than 6 page) articles will provide illustrations of the state of the field 20 years ago. The new articles will describe what has been learned about the subject in the following 20 years, and pose specific challenges for the next 20 years. The second historical mechanism will be the reproduction of the first 12 years of posters from the CNS meeting. These posters in and of themselves have become famous in the field (they hang in the halls of the NIH in Bethesda Maryland) and were constructed as allegories for the state and development of computational neuroscience. The posters were designed by the book’s editor, who will, for the first time, provide a written description of each poster.