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Computational Systems Pharmacology And Toxicology

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Computational Systems Pharmacology And Toxicology

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Author : Rudy J Richardson
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-03-01

Computational Systems Pharmacology And Toxicology written by Rudy J Richardson and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-01 with Science categories.

The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment. This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics. This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.

Computational Systems Pharmacology And Toxicology

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Author : Rudy J Richardson
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-03-03

Computational Methods For Reproductive And Developmental Toxicology

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Author : Donald R. Mattison
language : en
Publisher: CRC Press
Release Date : 2015-12-02

Computational Methods For Reproductive And Developmental Toxicology written by Donald R. Mattison and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-02 with Medical categories.

Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology.The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three br

Computational Systems Toxicology

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Author : Julia Hoeng
language : en
Publisher: Humana
Release Date : 2016-10-29

Computational Systems Toxicology written by Julia Hoeng and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-29 with Medical categories.

This detailed volume explores key state-of-the-art computational applications that are crucial in Systems Toxicology. The recent technological developments in experimental biology and multi-omics measurements that enable Systems Biology and Systems Toxicology can only be fully leveraged by the application of a broad range of computational approaches ranging from data management to mathematical modeling. Taking this into account, chapters in this book cover data management and processing, data analysis, biological network building and analysis, as well as the application of computational methods to toxicological assessment. Written for the Methods in Pharmacology and Toxicology series, Computational Systems Toxicology includes the kind of key practical advice that will aid readers in furthering our knowledge of toxic substances and reactions to them.

Nanoparticle Protein Corona

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Author : Ashutosh Kumar
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019-08-02

Nanoparticle Protein Corona written by Ashutosh Kumar and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-02 with Science categories.

Nanoparticles have numerous biomedical applications including drug delivery, bone implants and imaging. A protein corona is formed when proteins existing in a biological system cover the nanoparticle surface. The formation of a nanoparticle–protein corona, changes the behaviour of the nanoparticle, resulting in new biological characteristics and influencing the circulation lifetime, accumulation, toxicity, cellular uptake and agglomeration. This book provides a detailed understanding of nanoparticle–protein corona formation, its biological significance and the factors that govern the formation of coronas. It also explains the impact of nanoparticle–protein interactions on biological assays, ecotoxicity studies and proteomics research. It will be of interest to researchers studying the application of nanoparticles as well as toxicologists and pharmaceutical chemists.

Fish Species In Environmental Risk Assessment Strategies

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Author : Guillermo Eli Liwszyc
language : en
Publisher: Royal Society of Chemistry
Release Date : 2024-10-04

Fish Species In Environmental Risk Assessment Strategies written by Guillermo Eli Liwszyc and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-04 with Science categories.

With the expansion of human settlements and the environmental changes brought on by human activity and pollutants, toxicology and risk assessment of piscine species is becoming increasingly of interest to scientists involved in environmental research and connected disciplines. This book focuses specifically on environmental risk assessment in fish species from different zoogeographical regions of the world. Fish Species in Environmental Risk Assessment Strategies is an ideal companion to toxicologists and ecologists interested in risk assessment in the environments of ichthyic fauna, particularly those with an interest in the deleterious impact introduced by human activity. The book is also of interest to those working in conservation biology, biological invasion, biocontrol, habitat management and related disciplines.

Big Data In Predictive Toxicology

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Author : Daniel Neagu
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019-12-04

Big Data In Predictive Toxicology written by Daniel Neagu and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-04 with Medical categories.

The rate at which toxicological data is generated is continually becoming more rapid and the volume of data generated is growing dramatically. This is due in part to advances in software solutions and cheminformatics approaches which increase the availability of open data from chemical, biological and toxicological and high throughput screening resources. However, the amplified pace and capacity of data generation achieved by these novel techniques presents challenges for organising and analysing data output. Big Data in Predictive Toxicology discusses these challenges as well as the opportunities of new techniques encountered in data science. It addresses the nature of toxicological big data, their storage, analysis and interpretation. It also details how these data can be applied in toxicity prediction, modelling and risk assessment. This title is of particular relevance to researchers and postgraduates working and studying in the fields of computational methods, applied and physical chemistry, cheminformatics, biological sciences, predictive toxicology and safety and hazard assessment.

Amphibian Species In Environmental Risk Assessment Strategies

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Author : Marcelo L Larramendy
language : en
Publisher: Royal Society of Chemistry
Release Date : 2023-12-18

Amphibian Species In Environmental Risk Assessment Strategies written by Marcelo L Larramendy and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-18 with Science categories.

With the expansion of human settlements and the environmental changes brought about by human activity and pollutants, toxicology and risk assessment of amphibian species has become increasingly of interest to toxicologists involved in environmental research. This book focuses specifically on environmental risk assessment in premetamorphic stages and adults of amphibians. Amphibian ecotoxicology is not totally understood in scientific research and as such environmental risk assessment in these vertebrates is an area of rapidly growing interest. It has the potential to answer some of the questions regarding risks to our environment. An ideal companion, this book will be useful to toxicologists and ecologists investigating risk assessment in the environments of amphibians, while also of interest to those working in conservation biology, biological invasion, biocontrol and habitat management.

Ecotoxicology And Genotoxicology

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Author : Marcelo L Larramendy
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-07-05

Ecotoxicology And Genotoxicology written by Marcelo L Larramendy and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-05 with Science categories.

The potential impact of anthropogenic pollutants such as agrochemicals on the environment is of global concern. Increasing use of certain compounds can result in contamination of food, water and atmospheric systems and in order to combat this pollution it is important to be able to accurately monitor the short and long term effects. This book describes the latest aquatic species models used as indicators of the toxic effects of environmental pollutants, including models that have not routinely been used. The book enables understanding of the effects of pollutants in non-target species, and therefore enables analysis of the effects on ecosystems. This book will be of interest to anyone interested in developing new biomarker species with high degrees of ecological relevance. It will serve as a useful resource for regulatory and research toxicologists, particularly those studying freshwater, marine water and sediment environments.

Formaldehyde

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Author : Luoping Zhang
language : en
Publisher: Royal Society of Chemistry
Release Date : 2018-05-24

Formaldehyde written by Luoping Zhang and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-24 with Medical categories.

Formaldehyde is virtually ubiquitous in the modern environment due to its cost-effective nature, its use in resin formation, and its preservative properties. Though formaldehyde is necessary for many products and processes important to the world’s economy, this economic dependence on formaldehyde comes at a cost to public health. Growth and consequent industrialization rely heavily on formaldehyde use. New buildings—residences, public places, and offices—are not only built with timber preserved by formaldehyde, but they are also furnished with wood, wool, and textile products that contain formaldehyde. The general population faces environmental exposure from indoor and outdoor air pollution, food, and even medicine. Scientific inquiry into formaldehyde exposure has grown in response. This book consolidates the new and established body of formaldehyde research in the scholarly community, focusing on exposure, genotoxicity, and adverse health outcomes. Through this resource, we hope to increase awareness of the broad range of health effects posed by formaldehyde exposure, and to encourage interdisciplinary interest, as well as research, into this pervasive compound—especially in the United States and China, where formaldehyde production and usage is high. This book will be useful to researchers of environmental and occupational exposure, students, and government regulators and anyone exposed to formaldehyde in the workplace and/or at home.

Computational Systems Pharmacology And Toxicology

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