Computer Aided Applications In Pharmaceutical Technology
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Computer Aided Applications In Pharmaceutical Technology
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Author : Jelena Duris
language : en
Publisher: Woodhead Publishing
Release Date : 2023-09-13
Computer Aided Applications In Pharmaceutical Technology written by Jelena Duris and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-13 with Medical categories.
Computer-Aided Applications in Pharmaceutical Technology: Delivery Systems, Dosage Forms, and Pharmaceutical Unit Operations, Second Edition covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with an emphasis on their applications in process control, neural computing, data science, computer-aided biopharmaceutical characterization, as well as the application of computational fluid dynamics in pharmaceutical technology. Completely updated, the book introduces the theory and practice of computational tools through new case studies. Chapters cover Quality by Design in pharmaceutical development, overview data mining methodologies, present computer-aided formulation development, cover experimental design applications, and much more.
Computer Aided Applications In Pharmaceutical Technology
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Author : Jelena Djuris
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-04-10
Computer Aided Applications In Pharmaceutical Technology written by Jelena Djuris and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-10 with Technology & Engineering categories.
This chapter provides a basic theoretical background on experimental design application and interpretation. Techniques described include screening designs, full and fractional factorial designs, Plackett–Burman design, D-optimal designs, response surface methodology, central composite designs, Box–Behnken design, and mixture designs, etc. The reader will be introduced to the experimental domains covered by specific design, making it easier to select the one appropriate for the problem. After theoretical introduction, a number of illustrative examples of design of experiments application in the field of pharmaceutical technology are presented.
Computer Aided Applications In Pharmaceutical Technology
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Author : Jelena Duris
language : en
Publisher: Elsevier
Release Date : 2023-09-07
Computer Aided Applications In Pharmaceutical Technology written by Jelena Duris and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-07 with Medical categories.
Computer-Aided Applications in Pharmaceutical Technology: Delivery Systems, Dosage Forms, and Pharmaceutical Unit Operations, Second Edition covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with an emphasis on their applications in process control, neural computing, data science, computer-aided biopharmaceutical characterization, as well as the application of computational fluid dynamics in pharmaceutical technology. Completely updated, the book introduces the theory and practice of computational tools through new case studies. Chapters cover Quality by Design in pharmaceutical development, overview data mining methodologies, present computer-aided formulation development, cover experimental design applications, and much more. - Presents a comprehensive review of the current state of the art on various computer-aided applications in pharmaceutical technology - Includes case studies to facilitate understanding of various concepts in computer-aided applications - Covers applications such as the development of dosage forms and/or delivery systems, pharmaceutical unit operations, and relevant physiologically based pharmacokinetic simulations
Computer Aided Applications In Pharmaceutical Technology
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Author : Jelena Djuris
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-04-10
Computer Aided Applications In Pharmaceutical Technology written by Jelena Djuris and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-10 with Technology & Engineering categories.
This chapter presents a review of the possible applications of methods based on neural computing in pharmaceutical products and process development. Some of the methods described are used for classification purposes, whereas others can be applied to modeling and optimization, or even induction of rules. Basic concepts of each method are theoretically described, followed by examples of their application in pharmaceutical technology. A theoretical background aims to provide a better understanding of the methods and is based upon their most important features. Examples should encourage the reader to embrace the above-mentioned methods and use them to complement conventional statistical methods for classification and regression.
Computer Aided Applications In Pharmaceutical Technology
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Author : Sandra Grbic
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-04-10
Computer Aided Applications In Pharmaceutical Technology written by Sandra Grbic and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-10 with Technology & Engineering categories.
This chapter introduces the concept of gastrointestinal absorption simulation using in silico methodology. Parameters used for model construction and the sensitivity predicted pharmacokinetic responses to various input parameters are described. Virtual trials for in silico modeling of drug absorption are presented. The influence of food on drug absorption, as well as correlation between the in vitro and in vivo results, are also addressed, followed by biowaiver considerations. Numerous examples are provided throughout the chapter.
Computer Aided Applications In Pharmaceutical Technology
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Author : Ljiljana Djekic
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-04-10
Computer Aided Applications In Pharmaceutical Technology written by Ljiljana Djekic and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-10 with Technology & Engineering categories.
This chapter introduces the concept of formulation development assisted by computer applications. Development and optimization of various types of pharmaceutical emulsions microemulsions, self-microemulsifying systems, and double emulsions are presented. Illustrative examples are presented to demonstrate the ability of computer-aided tools to facilitate formulation development. Various techniques, such as design of experiments and artificial neural networks, are implemented for optimization of the formulation and/or processing parameters. Furthermore, some of the critical quality attributes and processing parameters are optimized simultaneously. The examples presented should serve as the foundation for the future quality-by-design development of pharmaceutical emulsion and (self) microemulsion formulations.
Computer Aided Applications In Pharmaceutical Technology
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Author : Ivana Masic
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-04-10
Computer Aided Applications In Pharmaceutical Technology written by Ivana Masic and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-10 with Technology & Engineering categories.
This chapter introduces the concept of computational fluid dynamics (CFD) and its applications in pharmaceutical technology. Basic theoretical explanations on the mathematics of fluid flow and numerical grids are provided. CFD is a versatile tool that is mainly used in complex dynamical process characterization. Examples of CFD applications in development of inhalers, analysis of dissolution apparatus hydrodynamics, and fluidized bed process simulations are presented.
Computer Aided Applications In Pharmaceutical Technology
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Author : Jelena Djuris
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-04-10
Computer Aided Applications In Pharmaceutical Technology written by Jelena Djuris and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-10 with Technology & Engineering categories.
This first chapter introduces the concept of quality-by-design (QbD) and its role in pharmaceutical product development. QbD assures the quality of a pharmaceutical product through scientific development and risk management tools, and will eventually enable real-time release, regardless of the formulation type. Several guidelines on pharmaceutical development, quality risk management, and pharmaceutical quality systems are presented that are applicable throughout the product lifecycle. Design space appointment and control strategies for risk management are introduced. The meaning of the QbD concept is presented from both regulatory and manufacturers’ points of view. Several illustrative examples are provided to facilitate the understanding of the QbD concept and ease of its application.
Computer Aided Applications In Pharmaceutical Technology
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Author : Jelena Djuris
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-04-10
Computer Aided Applications In Pharmaceutical Technology written by Jelena Djuris and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-10 with Technology & Engineering categories.
This chapter provides a basic theoretical background on chemometrics and chemometric methods for the analysis of multivariate data. Multivariate data analysis is essential for both product and process development and optimization. Depending on the problem studied, classification and/or regression multivariate methods are applied for data analysis. Different supervised and unsupervised methods for classification and regression are presented, followed by examples of their application in pharmaceutical technology. Some of the methods described include principal component analysis, various supervised classification methods, multiple linear regression, principal component regression, partial least squares regression, support vector machines, etc.
Computer Aided Pharmaceutics And Drug Delivery
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Author : Vikas Anand Saharan
language : en
Publisher: Springer Nature
Release Date : 2022-05-30
Computer Aided Pharmaceutics And Drug Delivery written by Vikas Anand Saharan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-30 with Medical categories.
This book examines the role of computer-assisted techniques for discovering, designing, optimizing and manufacturing new, effective, and safe pharmaceutical formulations and drug delivery systems. The book discusses computational approaches, statistical modeling and molecular modeling for the development and safe delivery of drugs in humans. The application of concepts of QbD (Quality by Design), DoE (Design of Experiments), artificial intelligence and in silico pharmacokinetic assessment/simulation have been made a lot easier with the help of commercial software and expert systems. This title provides in-depth knowledge of such useful software with illustrations from the latest researches. The book also fills in the gap between pharmaceutics and molecular modeling at micro, meso and maro scale by covering topics such as advancements in computer-aided Drug Design (CADD), drug-polymer interactions in drug delivery systems, molecular modeling of nanoparticles and pharmaceutics/bioinformatics. This book provides abundant applications of computers in formulation designing and characterization are provided as examples, case studies and illustrations. Short reviews of software, databases and expert systems have also been added to culminate the interest of readers for novel applications in formulation development and drug delivery. Computer-aided pharmaceutics and drug delivery is an authoritative reference source for all the latest scholarly update on emerging developments in computed assisted techniques for drug designing and development. The book is ideally designed for pharmacists, medical practitioners, students and researchers.