Concepts And Models For Drug Permeability Studies
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Concepts And Models For Drug Permeability Studies
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Author : Bruno Sarmento
language : en
Publisher: Elsevier
Release Date : 2024-02-23
Concepts And Models For Drug Permeability Studies written by Bruno Sarmento and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-23 with Medical categories.
Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs.This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-derived tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route.Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models. Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules. - Summarizes the current advances in the use of permeability models in drug transport - Covers the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, renal, skin, and blood–brain barrier in vitro models. Includes case studies to facilitate understanding of various concepts in computer-aided applications - Updates in the second edition include organ-on-chip devices, 3D advanced models (multiple layered tissues, organoids, etc.), and multicompartmentalized tissue models
Hydrogels In Drug Delivery
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Author : Alejandro J. Paredes
language : en
Publisher: Elsevier
Release Date : 2025-02-22
Hydrogels In Drug Delivery written by Alejandro J. Paredes and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-22 with Technology & Engineering categories.
Hydrogels in Drug Delivery: Advances in the Manufacture, Characterization, and Application of Hydrogels to Address Current Global Healthcare Challenges presents the latest advances in hydrogels, ranging from their basic chemistry to specific application of existing and novel hydrogels in controlled drug delivery and biomedicine. Hydrogels have been increasingly used in the development of novel formulations in a wide variety of therapeutic and monitoring applications. Multidisciplinary work carried out by researchers working in synthetic chemistry, drug delivery, biomedicine and other fields has led to the development of novel polymers, enabling the preparation of hydrogels with adjustable physicochemical properties. Accordingly, these materials offer multiple advantages over other drug delivery systems, including an increased patient compliance by reducing the required number of medication doses, reducing the healing time in injuries, and simplifying patient monitoring by reducing the invasiveness of current methods.Hydrogels in Drug Delivery is an essential resource for graduate students and researchers working within drug delivery and synthetic chemistry, biomedicine, material science, pharmacology, and chemical engineering. - Covers the fundamental mechanisms of drug delivery from a hydrophilic matrix - Breaks down interconnections between introductory theory and applied materials chapters - Includes experimental pictures and links to multimedia features including videos and slides
The Blood Brain Barrier
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Author : Nicole Stone
language : en
Publisher: Springer Nature
Release Date : 2022-06-22
The Blood Brain Barrier written by Nicole Stone and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-22 with Medical categories.
This detailed volume features techniques to explore the complex interface that separates the systemic circulation from the central nervous system, known as the blood-brain barrier (BBB). Beginning with an introduction to its physiology, the book continues with sections on using pluripotent stem cells in models of the BBB, co-culture, permeability and transwell models, microfluidic and chip models, as well as models to study specific BBB pathologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The Blood-Brain Barrier: Methods and Protocols collects a wide range of methodologies which will aid all researchers in the fascinating world of the blood-brain barrier.
Physico Chemical Aspects Of Dosage Forms And Biopharmaceutics
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Author : Amit Kumar Nayak
language : en
Publisher: Elsevier
Release Date : 2024-08-09
Physico Chemical Aspects Of Dosage Forms And Biopharmaceutics written by Amit Kumar Nayak and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-09 with Medical categories.
Physico-Chemical Aspects of Dosage Forms and Biopharmaceutics: Recent and Future Trends in Pharmaceutics, Volume Two explores aspects of pharmaceutics with an original approach that focuses on technology, novelties and future trends. The field of pharmaceutics is highly dynamic and rapidly expanding day-by-day, so it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. Readers will find practical information for conducting research in pharmaceutics that is ideal for researchers in academia and industry as well as advanced graduate students in pharmaceutics. In addition, the book discusses the most recent developments in biopharmaceutics, including important and exciting areas such as solubility of drugs, pharmaceutical granulation, routes of drug administration, drug absorption, bioavailability and bioequivalence. - Provides extensive details on the most recent developments in biopharmaceutics - Contains contributions from leading experts from academia, research, industry and regulatory agencies - Includes high quality illustrations, flow charts and tables for easier understanding of the concepts - Discusses practical examples and research case studies
Nanoparticles In Life Sciences And Biomedicine
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Author : Ana Rute Neves
language : en
Publisher: CRC Press
Release Date : 2018-02-13
Nanoparticles In Life Sciences And Biomedicine written by Ana Rute Neves and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-13 with Medical categories.
The creation of new and more efficient therapies for improving human health greatly depends on drug delivery systems. Nanotechnology has emerged as a powerful strategy for the development of nanoparticles, such as nanoemulsions, liposomes, nanocrystals, and nanocomplexes, applied in the diagnosis, treatment, or theranostics of several pathologies and diseases. This book reviews the most recent research and development in nanotechnology and, following a multidisciplinary approach, presents new strategies for drug delivery, including aspects from chemistry, physics, biology, and imaging methodologies and exploiting several administration routes, internalization pathways, site-specific delivery strategies, and the potential cytotoxicity of nanoparticles. Beginning with a description of the importance and application of nanotechnology for enhancing existing therapy, the book moves on to detailing oral, topical, pulmonary, brain, cancer, and anti-inflammatory drug delivery approaches; gene delivery approaches; theranostic approaches; and nanoparticle cytotoxicity. Practical and user friendly, it is suitable for advanced undergraduate, graduate, and postgraduate students of nanoscience and nanotechnology; researchers in nanoscience, nanotechnology, chemistry, biology, biochemistry, pharmaceutical sciences, medicine, and bioengineering, especially those with an interest in drug delivery or theranostics; and academia and university readership.
When The Shape Does Matter Three Dimensional In Vitro Models Of Epithelial Barriers
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Author : Elena Martinez
language : en
Publisher: Frontiers Media SA
Release Date : 2021-01-18
When The Shape Does Matter Three Dimensional In Vitro Models Of Epithelial Barriers written by Elena Martinez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-18 with Science categories.
Recent Progress In Nanobiotechnology
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Author : P. M. Visakh
language : en
Publisher: Springer Nature
Release Date : 2024-06-30
Recent Progress In Nanobiotechnology written by P. M. Visakh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-30 with Science categories.
This book describes recent important advancements in nanobiotechnology for biomedical applications as well as explaining fundamentals and examining potential applications in biomedical settings. Nanobiotechnology is the study of applications of nanotechnologies in biological or biomedical settings. It is an interdisciplinary field of growing importance whose subcategories encompass chemical engineering, molecular biophysics, and cellular mechanics or tissue engineering. This book is structured in a way to summarize the latest process in nanobiotechnology at the molecular, cellular, tissue, and organ levels. The principles of the underlying science are presented, and widely accepted applications in the field and newly designed techniques are extensively described. Fresh insights are provided into the convergence of science and technology. This book is an ideal guide to the field that will be of value especially for researchers from interdisciplinary fields and higher level graduate students with extraordinary inspirations and research training.
Advances In Plant Biotechnology
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Author : Alma Angélica Del Villar-Martínez
language : en
Publisher: CRC Press
Release Date : 2023-08-31
Advances In Plant Biotechnology written by Alma Angélica Del Villar-Martínez and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-31 with Technology & Engineering categories.
The goal of Advances in Plant Biotechnology is to integrate the most recent knowledge on tissue culture, secondary metabolites production under controlled conditions, scaling up to produce them at bioreactor level, and their industrial applications. The biosynthetic pathways and the factors that affect them and the accumulation of metabolites, including metabolomics in medicinal plants, are key components as well. Several extraction and encapsulation technological procedures are reviewed. The structure and function of metabolites from selected commercial crops are reported in detail. Finally, items of paramount importance, such as bioavailability and stability of metabolites in pharma and food products are deeply analyzed. Key Features: Strategies for obtaining selected metabolites through in vitro culture Application of biotechnological and bioengineering principles to the management of plant metabolites Description of the encapsulation of selected metabolites Bioavailability and stability of metabolites in pharma, food, and industrial sectors This book is mainly addressed to research scientists, technical staff, and private and public organizations involved in plant biotechnology and in its processing industries. Last, but not least, students at all levels and postdoctoral researchers have received special attention from all editors and authors in this publication.
Characterization Of Pharmaceutical Nano And Microsystems
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Author : Leena Peltonen
language : en
Publisher: John Wiley & Sons
Release Date : 2020-10-27
Characterization Of Pharmaceutical Nano And Microsystems written by Leena Peltonen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-27 with Science categories.
Learn about the analytical tools used to characterize particulate drug delivery systems with this comprehensive overview Edited by a leading expert in the field, Characterization of Pharmaceutical Nano- and Microsystems provides a complete description of the analytical techniques used to characterize particulate drug systems on the micro- and nanoscale. The book offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker. Characterization of Pharmaceutical Nano- and Microsystems deals with a wide variety of topics relevant to chemical and solid-state analysis of drug delivery systems, including drug release, permeation, cell interaction, and safety. It is a complete resource for those interested in the development and manufacture of new medicines, the drug development process, and the translation of those drugs into life-enriching and lifesaving medicines. Characterization of Pharmaceutical Nano- and Microsystems covers all of the following topics: An introduction to the analytical tools applied to determine particle size, morphology, and shape Common chemical approaches to drug system characterization A description of solid-state characterization of drug systems Drug release and permeation studies Toxicity and safety issues The interaction of drug particles with cells Perfect for pharmaceutical chemists and engineers, as well as all other industry professionals and researchers who deal with drug delivery systems on a regular basis, Characterization of Pharmaceutical Nano- and Microsystems also belongs on bookshelves of interested students and faculty who interact with this topic.
Transmucosal Absorption Enhancers In The Drug Delivery Field
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Author : Luca Casettari
language : en
Publisher: MDPI
Release Date : 2020-01-07
Transmucosal Absorption Enhancers In The Drug Delivery Field written by Luca Casettari and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-07 with Medical categories.
Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.