Concepts In Eukaryotic Dna Replication
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Concepts In Eukaryotic Dna Replication
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Author : Melvin L. DePamphilis
language : en
Publisher:
Release Date : 1999
Concepts In Eukaryotic Dna Replication written by Melvin L. DePamphilis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Science categories.
National Institutes of Health, Bethesda, MD. Abridged version of the first fourteen chapters of the monograph: DNA Replication in Eukaryotic Cells, c1996, by DePamphilis. Recent advances are summarized in a new chapter: DNA Replication in Eukaryotic Cells: 1996 to 1998. For students and researchers. Softcover.
Dna Replication
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Author : Hisao Masai
language : en
Publisher: Springer
Release Date : 2018-01-22
Dna Replication written by Hisao Masai and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-22 with Science categories.
This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.
New Approaches In Eukaryotic Dna Replication
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Author : A. De Recondo
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
New Approaches In Eukaryotic Dna Replication written by A. De Recondo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
DNA replication in eukaryotes is an important field, particular ly because of its direct impact on the study of cancer. The under standing of molecular mechanisms of replication and their regulation should allow a better comprehension of the alterations that lead to the proliferation of tumor cells and to error-prone repair in cells exposed to radiation or chemical carcinogens. During the last several years, many enzymes and proteins which participate in replication of DNA in eukaryotic cells have been identified, isolated and characterized. New concepts in chromatin structure have refocused attention on the study of replication of DNA complexed with his tones and non-histone chromosomal proteins. However, progress has been noticeably slower than for prokaryotes, essentially because of the difficulty in genetic analysis of eukaryo tic DNA replication. In June 1980, a workshop was organized in Cargese, Corsica (France) to facilitate exchanges of information between workers spe cializing in prokaryotes and those specializing in eukaryotes, and to allow discussion of new experimental approaches. With this in mind, special interest has been taken in the origin and termination of chromosome cycles and how they are controlled.
Concepts Of Biology
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Author : Samantha Fowler
language : en
Publisher:
Release Date : 2018-01-07
Concepts Of Biology written by Samantha Fowler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-07 with Science categories.
Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.
Dna Replication In Eukaryotic Cells
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Author : Melvin L. DePamphilis
language : en
Publisher: CSHL Press
Release Date : 1996
Dna Replication In Eukaryotic Cells written by Melvin L. DePamphilis and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
National Institutes of Health. Cold Spring Harbor Monograph, Volume 31 Extensive text on the replication of DNA, specifically in eukaryotic cells, for researchers. 68 contributors, 54 U.S.
Dna Replication
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Author : Hisao Masai
language : en
Publisher:
Release Date : 2017
Dna Replication written by Hisao Masai and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Biochemistry categories.
Eukaryotic Dna Replication
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Author : Sue Cotterill
language : en
Publisher: OUP Oxford
Release Date : 1999-02-18
Eukaryotic Dna Replication written by Sue Cotterill and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-02-18 with Science categories.
Eukaryotic DNA Replication: A Practical Approach is a comprehensive practical manual, with each of its eleven chapters describing an aspect of the methods currently used to investigate DNA replication in eukaryotes. The sequence of the chapters corresponds roughly to the order of events during DNA replication. The first chapters are concerned with initiation, looking at methods to characterize origins of replication and the proteins that interact with them. There then follow chapters describing protocols for the study of the elongation phase and the synthesis of the telomeres. The final chapters provide a more general overview of the study of DNA replication - including its investigation in model systems such as yeast, xenopus and viruses, and looks into methods used to study DNA:protein interactions that could be applied to the study of replication proteins. This exciting new volume provides over 120 tried and tested protocols for the analysis of eukaryotic DNA replication and will be of major interest to a wide variety of molecular and cell biologists, biochemists and medical researchers.
The Initiation Of Dna Replication In Eukaryotes
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Author : Daniel L. Kaplan
language : en
Publisher:
Release Date : 2016
The Initiation Of Dna Replication In Eukaryotes written by Daniel L. Kaplan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Cytology categories.
Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.
The Initiation Of Dna Replication In Eukaryotes
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Author : Daniel L. Kaplan
language : en
Publisher: Springer
Release Date : 2016-02-11
The Initiation Of Dna Replication In Eukaryotes written by Daniel L. Kaplan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-11 with Medical categories.
Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.
Replicating And Repairing The Genome From Basic Mechanisms To Modern Genetic Technologies
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Author : Kenneth N Kreuzer
language : en
Publisher: World Scientific
Release Date : 2020-03-16
Replicating And Repairing The Genome From Basic Mechanisms To Modern Genetic Technologies written by Kenneth N Kreuzer and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-16 with Science categories.
Replicating and Repairing the Genome provides a concise overview of the fields of DNA replication and repair. The book is particularly appropriate for graduate students and advanced undergraduates, and scientists entering the field or working in related fields. The breadth of information regarding DNA replication and repair is vast and often difficult to absorb, with terminology that differs between experimental systems and with complex interconnections of these processes with other cellular pathways. This book provides simple conceptual descriptions of replication and repair pathways using mostly generic protein names, laying out the logic for how the pathways function and highlighting fascinating aspects of the underlying biochemical mechanisms and biology. The book incorporates extensive and informative diagrams and figures, as well as descriptions of a number of carefully chosen experiments that had major influences in the field.The process of DNA replication is explained progressively by starting with the system of a simple bacterial virus that uses only a few proteins, followed by the well-understood bacterial (E coli) system, and then culminating with the more complex eukaryotic systems. In the second half of the book, individual chapters cover key areas of DNA repair — postreplication repair of mismatches and incorporated ribonucleotides, direct damage reversal, excision repair, and DNA break repair, as well as the related areas of DNA damage tolerance (including translesion DNA polymerases) and DNA damage responses. The book closes with chapters that describe the huge impact of DNA replication and repair on aspects of human health and on modern biotechnology.