Conceptual Modelling In Computational Immunology

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Conceptual Modelling In Computational Immunology
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Author : Martina Husáková
language : en
Publisher: Tomáš Bruckner
Release Date : 2015-09-10
Conceptual Modelling In Computational Immunology written by Martina Husáková and has been published by Tomáš Bruckner this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-10 with Computers categories.
Computational immunology offers in silico strategies for understanding of complex processes occurring in the natural immune system of a living organism that are difficult to explore by traditional in vivo or in vitro techniques. The monograph introduces conceptual languages and approaches for modelling biological processes. The Agent Modelling Language is investigated for conceptualisation of immune processes. AML-based diagrams represent properties and processes occurring in a lymph node.
Conceptual Modelling In Computational Immunology
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Author : Martina Husakova
language : en
Publisher: Tomas Bruckner
Release Date : 2015-09-10
Conceptual Modelling In Computational Immunology written by Martina Husakova and has been published by Tomas Bruckner this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-10 with Computers categories.
The natural immune system is an amazing complex system aiming at the homeostasis maintenance of a living organism. The non-linear, dynamic and complex nature of this system renders the behaviour far from predictable. This fact complicates exploration of immune processes and their understanding with traditional in vivo or in vitro strategies. Techniques of computer science are a promising alternative for the investigation of the natural immune system. Computational immunology investigates an inner life of the natural immune system with the assistance of various approaches of computer science (artificial or computational intelligence), mathematics, physics or statistics. It offers in silico strategies helping with the understanding of phenomena that are difficult to explore through traditional techniques. The monograph introduces the historical context of this research area and the first computer science-based applications. It concentrates mainly on conceptual modelling of various biological processes with the usage of particular conceptual languages and approaches (concept maps, entity-relationship diagrams, ontologies, topic maps, SBML, CellML, SBGN, statecharts and UML) differing in the degree of formality and use. Conceptual models are crucial, because they highlight the most important "players" of immune processes and relations between them. Conceptualisation is inevitable especially if we study really complex system. The primary goal of the monograph is to investigate the usefulness of the Agent Modelling Language for conceptualisation of particular immune processes. The Agent Modelling Language (AML) extends the UML for conceptualisation of multi-agent systems. The natural immune system is perceived as the multi-agent system in the monograph. Selected types of AML-based diagrams represent properties and processes occurring in a secondary lymphoid organ - a lymph node where interactions between T-cells and dendritic cells are mainly taken into account.
Computational Collective Intelligence
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Author : Manuel Núñez
language : en
Publisher: Springer
Release Date : 2015-09-09
Computational Collective Intelligence written by Manuel Núñez and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-09 with Computers categories.
This two-volume set (LNAI 9329 and LNAI 9330) constitutes the refereed proceedings of the 7th International Conference on Collective Intelligence, ICCCI 2014, held in Madrid, Spain, in September 2015. The 110 full papers presented were carefully reviewed and selected from 186 submissions. They are organized in topical sections such as multi-agent systems; social networks and NLP; sentiment analysis; computational intelligence and games; ontologies and information extraction; formal methods and simulation; neural networks, SMT and MIS; collective intelligence in Web systems – Web systems analysis; computational swarm intelligence; cooperative strategies for decision making and optimization; advanced networking and security technologies; IT in biomedicine; collective computational intelligence in educational context; science intelligence and data analysis; computational intelligence in financial markets; ensemble learning; big data mining and searching.
Computational Immunology
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Author : Josep Bassaganya-Riera
language : en
Publisher: Academic Press
Release Date : 2015-10-21
Computational Immunology written by Josep Bassaganya-Riera and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-21 with Medical categories.
Computational Immunology: Models and Tools encompasses the methodological framework and application of cutting-edge tools and techniques to study immunological processes at a systems level, along with the concept of multi-scale modeling. The book's emphasis is on selected cases studies and application of the most updated technologies in computational modeling, discussing topics such as computational modeling and its usage in immunological research, bioinformatics infrastructure, ODE based modeling, agent based modeling, and high performance computing, data analytics, and multiscale modeling. There are also modeling exercises using recent tools and models which lead the readers to a thorough comprehension and applicability. The book is a valuable resource for immunologists, computational biologists, bioinformaticians, biotechnologists, and computer scientists, as well as all those who wish to broaden their knowledge in systems modeling. - Offers case studies with different levels of complexity - Provides a detailed view on cutting-edge tools for modeling that are useful to experimentalists with limited computational skills - Explores the usage of simulation for hypothesis generation, helping the reader to understand the most valuable points on experimental setting
Killer Cell Dynamics
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Author : Dominik Wodarz
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-04-05
Killer Cell Dynamics written by Dominik Wodarz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-05 with Mathematics categories.
Systems biology and computational biology have recently become prominent areas of research in the biomedical community, especially in the area of cell biology. Given that much information on genes and their protein products has become available, the big question is how the individual components interact and work together, and how this determines the functioning of cells, organs, and organisms. Long before the popularity of systems biology in biomedicine, however, such approaches have been used successfully in a di?erent area of biology: population ecology. Research in the area of population dynamics - vestigated complex interactions between di?erent populations of organisms, such as the dynamics of competition and predation, food webs, community structure, as well as the epidemiology of infectious diseases. In this ?eld, t- oretical biology and mathematical modeling have become an integral part of research. Mathematical models allowed people to obtain interesting and counter-intuitive insights into how complex interactions among di?erent p- ulations can play out. Such mathematical studies not only gave rise to - teresting theoretical ideas, but also provided the basis for the design of new experimental work and de?ned major questions and directions of research. Around 1990, such population dynamic concepts, and the use of mathema- cal/computational approaches, started to be applied to the in vivo dynamics between viruses and the immune system. These interactions have many s- ilarities to ecological, epidemiological, and evolutionary principles. Consider theepidemiologicalspreadofapathogen(suchasthecommoncold)througha population of hosts.
New Trends In Intelligent Information And Database Systems
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Author : Dariusz Barbucha
language : en
Publisher: Springer
Release Date : 2015-03-22
New Trends In Intelligent Information And Database Systems written by Dariusz Barbucha and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-22 with Technology & Engineering categories.
Intelligent information and database systems are two closely related subfields of modern computer science which have been known for over thirty years. They focus on the integration of artificial intelligence and classic database technologies to create the class of next generation information systems. The book focuses on new trends in intelligent information and database systems and discusses topics addressed to the foundations and principles of data, information, and knowledge models, methodologies for intelligent information and database systems analysis, design, and implementation, their validation, maintenance and evolution. They cover a broad spectrum of research topics discussed both from the practical and theoretical points of view such as: intelligent information retrieval, natural language processing, semantic web, social networks, machine learning, knowledge discovery, data mining, uncertainty management and reasoning under uncertainty, intelligent optimization techniques in information systems, security in databases systems, and multimedia data analysis. Intelligent information systems and their applications in business, medicine and industry, database systems applications, and intelligent internet systems are also presented and discussed in the book. The book consists of 38 chapters based on original works presented during the 7th Asian Conference on Intelligent Information and Database Systems (ACIIDS 2015) held on 23–25 March 2015 in Bali, Indonesia. The book is divided into six parts related to Advanced Machine Learning and Data Mining, Intelligent Computational Methods in Information Systems, Semantic Web, Social Networks and Recommendation Systems, Cloud Computing and Intelligent Internet Systems, Knowledge and Language Processing, and Intelligent Information and Database Systems: Applications.
Complex Systems And Computational Biology Approaches To Acute Inflammation
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Author : Yoram Vodovotz
language : en
Publisher: Springer Nature
Release Date : 2020-11-04
Complex Systems And Computational Biology Approaches To Acute Inflammation written by Yoram Vodovotz and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-04 with Medical categories.
This second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. In this second edition, we cover both well-established and emerging modeling methods, especially state-of-the-art machine learning approaches and the integration of data-driven and mechanistic modeling. This volume introduces the concept of Model-based Precision Medicine as an alternative approach to the current view of Precision Medicine, based on leveraging mechanistic computational modeling to decrease cost while increasing the information value of the data being obtained. By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-based Precision Medicine offers a window into the recent past, the present, and the future of computationally-augmented biomedical research.
Advances In Bioinformatics And Computational Biology
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Author : Osmar Norberto de Souza
language : en
Publisher: Springer
Release Date : 2011-07-21
Advances In Bioinformatics And Computational Biology written by Osmar Norberto de Souza and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-21 with Computers categories.
This book constitutes the proceedings of the 6th Brazilian Symposium on Bioinformatics, BSB 2011, held in Brasília, Brazil, in August 2011. The 8 full papers and 4 extended abstracts presented were carefully peer-reviewed and selected for inclusion in this book. The BSB topics of interest cover many areas of bioinformatics that range from theoretical aspects of problems in bioinformatics to applications in molecular biology, biochemistry, genetics, and associated subjects.
Computational Biology Of Cancer
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Author : Dominik Wodarz
language : en
Publisher: World Scientific
Release Date : 2005
Computational Biology Of Cancer written by Dominik Wodarz and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Science categories.
- Provides an introduction to computational methods in cancer biology - Follows a multi-disciplinary approach
Encyclopedia Of Bioinformatics And Computational Biology
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Author :
language : en
Publisher: Elsevier
Release Date : 2018-08-21
Encyclopedia Of Bioinformatics And Computational Biology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-21 with Medical categories.
Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases