Concomitant Chemoradiation
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Concomitant Continuous Infusion Chemotherapy And Radiation
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Author : Marvin Rotman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Concomitant Continuous Infusion Chemotherapy And Radiation written by Marvin Rotman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The administration of chemotherapeutic agents by continuous infusion with concomitant radiation therapy heralds a new approach in the treatment of cancer. This comprehensive book on the subject includes, besides a discussion of its scientific basis, the most promising clinical data on the use of continuous infusion chemotherapy and radiation. Thus, it is an important update for clinical investigators involved in frontline research as well as for practicing physicians participating in the direct care of cancer patients. The contributions include the latest results of this new approach in a number of tumor sites. There is a detailed description of the principles of radiosensitization for malignant tumors and radioprotection for normal tissues; these are the principles which have led to concrete clinical applications. There is also a presentation of the most recent data on the beneficial effects resulting from the administration of commonly used drugs, such as 5-fluorouracil, cisplatinum and adriamycin, with concomitant radiation therapy. Much of the data has never before been published. The wealth of information in this volume makes it a valuable reference; at the same time it gives practicing physicians a detailed presentation of various therapeutic regimens which they could administer in their daily clinical practice. In the future, this innovative cancer treatment may lead to the decreased need for radical surgery and the increased ability to preserve organ function.
Concomitant Chemoradiation
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Author : Françoise Mornex
language : en
Publisher:
Release Date : 1999
Concomitant Chemoradiation written by Françoise Mornex and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Cancer categories.
Clinical Applications Of Continuous Infusion Chemotherapy And Concomitant Radiation Therapy
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Author : C. Julian Rosenthal
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Clinical Applications Of Continuous Infusion Chemotherapy And Concomitant Radiation Therapy written by C. Julian Rosenthal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The first conference on concomitant infusion chemotherapy and radia tion therapy was organized with the intention of bringing together some of the investigators who have tested, during the last few years, the hypo thesis that continuous infusion chemotherapy could modulate the cytotoxic effect of radiation therapy to the point of having a strongly additive, if not synergistic activity on certain malignant tumors. This volume represents the detailed proceedings of this conference presented in a way that offers the reader a review of the on-going re search in the field. We have stressed a number of subjects from basic biologic research and influence of cell kinetics to the practical methods of drug delivery systems and early clinical experiences. The rationale for this new type of combined modality therapy has been presented by some of its pioneers. Early clinical investigations as well as the preliminary data of many that have not yet completely matured have also been included. The reader should look at these data with some reser vations. Ultimately, these results must be confirmed by larger prospective randomized studies with proper controls before becoming accepted as the treatment of choice in locally advanced tumors.
Concomitant Chemoradiation In Locally Advanced Head And Neck Carcinoma At University Of Malaya Medical Centre
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Author : Mastura Md Yusof
language : en
Publisher:
Release Date : 2009
Concomitant Chemoradiation In Locally Advanced Head And Neck Carcinoma At University Of Malaya Medical Centre written by Mastura Md Yusof and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Chemoradiation In Cancer Therapy
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Author : Hak Choy
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-12-04
Chemoradiation In Cancer Therapy written by Hak Choy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-04 with Medical categories.
Internationally recognized experts in cancer biology and clinical research review the present status of the multimodality approach to the management of solid tumors and speculate on possible future strategies for chemoradiation therapy. The authors detail applications of combined modality therapy in lung, esophageal, breast, gastric, pancreatic, colon, and rectal cancers. They also show how radiation interacts with such chemotherapeutic agents as the platinum complexes, taxanes, and gemcitabine in the treatment of malignant gliomas, and head and neck cancer. A review of how to integrate new specific molecular targeted agents into multimodality therapy in the future.
Evaluation Of Concomitant Systemic Treatment In Older Adults With Head And Neck Squamous Cell Carcinoma Undergoing Definitive Radiotherapy
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Author : Alexander Rühle
language : en
Publisher:
Release Date : 2023
Evaluation Of Concomitant Systemic Treatment In Older Adults With Head And Neck Squamous Cell Carcinoma Undergoing Definitive Radiotherapy written by Alexander Rühle and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Abstract: Importance The number of older adults with head and neck squamous cell carcinoma (HNSCC) is increasing, and these patients are underrepresented in clinical trials. It is unclear whether the addition of chemotherapy or cetuximab to radiotherapy is associated with improved survival in older adults with HNSCC. Objective To examine whether the addition of chemotherapy or cetuximab to definitive radiotherapy is associated with improved survival in patients with locoregionally advanced (LA) HNSCC. Design, Setting, and Participants The Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy (SENIOR) study is an international, multicenter cohort study including older adults (≥65 years) with LA-HNSCCs of the oral cavity, oropharynx/hypopharynx, or larynx treated with definitive radiotherapy, either alone or with concomitant systemic treatment, between January 2005 and December 2019 at 12 academic centers in the US and Europe. Data analysis was conducted from June 4 to August 10, 2022. Interventions All patients underwent definitive radiotherapy alone or with concomitant systemic treatment. Main Outcomes and Measures The primary outcome was overall survival. Secondary outcomes included progression-free survival and locoregional failure rate. Results Among the 1044 patients (734 men [70.3%]; median [IQR] age, 73 [69-78] years) included in this study, 234 patients (22.4%) were treated with radiotherapy alone and 810 patients (77.6%) received concomitant systemic treatment with chemotherapy (677 [64.8%]) or cetuximab (133 [12.7%]). Using inverse probability weighting to attribute for selection bias, chemoradiation was associated with longer overall survival than radiotherapy alone (hazard ratio [HR], 0.61; 95% CI, 0.48-0.77; P .001), whereas cetuximab-based bioradiotherapy was not (HR, 0.94; 95% CI, 0.70-1.27; P = .70). Progression-free survival was also longer after the addition of chemotherapy (HR, 0.65; 95% CI, 0.52-0.81; P .001), while the locoregional failure rate was not significantly different (subhazard ratio, 0.62; 95% CI, 0.30-1.26; P = .19). The survival benefit of the chemoradiation group was present in patients up to age 80 years (65-69 years: HR, 0.52; 95% CI, 0.33-0.82; 70-79 years: HR, 0.60; 95% CI, 0.43-0.85), but was absent in patients aged 80 years or older (HR, 0.89; 95% CI, 0.56-1.41).
Chemoradiotherapy
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Author : Daniel Sullivan
language : en
Publisher: Nova Science Publishers
Release Date : 2017
Chemoradiotherapy written by Daniel Sullivan and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Chemotherapy categories.
Chemoradiotherapy is the use of both chemotherapy and radiotherapy for the treatment of cancer. This book discusses it's concurrent uses, efficacy in the medical field, and the impact it has on the prognosis of cancers.
Role Of Completion Hysterectomy After Concomitant Chemoradiation In Cervical Cancer Outcome
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Author : MARIA LUIZA DIAS
language : en
Publisher:
Release Date : 2017
Role Of Completion Hysterectomy After Concomitant Chemoradiation In Cervical Cancer Outcome written by MARIA LUIZA DIAS and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Objectives: To compare outcomes of patients with cervical cancertreated by chemoradiation alone (CRT) versus chemoradiationplus completion hysterectomy (CRT+CH).Methods: This is a retrospective comparison of 44 patients withinvasive cervical carcinoma treated by the combination ofchemoradiation plus completion hysterectomy (CRT+CH) and130 patients treated by chemoradiation alone (CRT), in a singleinstitution, from 2008 to 2018. CRT was the same to bothgroups: combination of external beam radiotherapy (EBRT) tothe pelvis and intracavitary brachytherapy and concomitantplatin-based chemotherapy. CH were performed after 6 to 12weeks from the end of CRT. All surgeries were Piver Ihysterectomy without lymph node dissection, performed bytraditional laparoscopic approach.In adittion to the raw data analysis, we used a propensitymatched analysis after pairing FIGO stage, histologic type andage of each group, to minimize selection bias and prove theresults.Results: In the raw data, FIGO (2009) stage in the study were as follow:30 IB2, 19 IIA, 125 IIB. There were 137 squamous cellcarcinomas (SCC) and 37 adenocarcinomas (ADC). Amongall cases, there were 36 recurrences (20.7%), being 29 (22.3%)in the CRT group and 7 (15.9%) in the CRT+CH group. Deathsoccurred in 79 cases (45.4%), being 71 in the CRT group(54.6%) and 8 in the CRT+CH group (18.2%). There was nodifference in complications among the two groups.29 pairs of cases were matched for the propensity analysis 1:1according to variables of FIGO, age and histologic type. Relapsesoccurred in 5 cases in the CRT + CH group and in 3 in the CRTalone group. Disease free was no different in the two group(p=0.933). Death occurred in 5 cases (17.2%) in the CRT + CHgroup, and 15 (51.7%) in the CRT alone group.Overall survival of the operative group was higher than the nonoperative group (97.01 VS 56.79 months) (p
Concomitant Treatment Of Colorectal Cancer With Platinum Based Chemotherapy And Radiation
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Author : Thititip Tippayamontri
language : en
Publisher:
Release Date : 2013
Concomitant Treatment Of Colorectal Cancer With Platinum Based Chemotherapy And Radiation written by Thititip Tippayamontri and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Concomitant Chemoradiotherapy For Solid Tumors
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Author : Everett E. Vokes
language : en
Publisher:
Release Date : 1992
Concomitant Chemoradiotherapy For Solid Tumors written by Everett E. Vokes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.