Connecting The Dots Between Inflammation And The Inner Workings Of Programmed Cell Death
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Connecting The Dots Between Inflammation And The Inner Workings Of Programmed Cell Death
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Author : Thomas Kaufmann
language : en
Publisher: Frontiers Media SA
Release Date : 2020-05-21
Connecting The Dots Between Inflammation And The Inner Workings Of Programmed Cell Death written by Thomas Kaufmann and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-21 with categories.
Programmed cell death (PCD) is central in maintaining the life of multicellular organisms, during development as well as in healthy adulthood or in the context of disease. The best understood form of PCD is apoptosis, a caspase mediated, immunologically silent cell death that can be initiated in probably all cell types upon aging, lack of growth support, critical damage or infection. One of the key pathways of apoptosis involves mitochondrial outer membrane permeabilization (MOMP), a process tightly regulated by members of the BCL-2 family. Whereas PCD and apoptosis were used synonymously in the past, other forms of PCD have been discovered more recently, including RIPK1/3- and MLKL-dependent necroptosis, resulting in a necrotic phenotype, and pyroptosis. Interestingly, key components of the necroptotic pathway are actively suppressed by apoptotic caspases, and this interconnection allows a switch in cell death modalities with greatly impact on the host’s immune response. Recent findings link mitochondria and/or MOMP to non-apoptotic forms of PCD, including ferroptosis and necroptosis, putting this organelle even more in the center of cellular death. This article collection highlights the exciting potential and as yet undiscovered regulation of programmed cell death that can impact the immune system and its response.
Plant Programmed Cell Death
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Author : Arunika N. Gunawardena
language : en
Publisher: Springer
Release Date : 2015-10-08
Plant Programmed Cell Death written by Arunika N. Gunawardena and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-08 with Science categories.
Programmed cell death (PCD) is a genetically encoded, active process which results in the death of individual cells, tissues, or whole organs. PCD plays an essential role in plant development and defense, and occurs throughout a plant’s lifecycle from the death of the embryonic suspensor to leaf and floral organ senescence. In plant biology, PCD is a relatively new research area, however, as its fundamental importance is further recognized, publications in the area are beginning to increase significantly. The field currently has few foundational reference books and there is a critical need for books that summarizes recent findings in this important area. This book contains chapters written by several of the world’s leading researchers in PCD. This book will be invaluable for PhD or graduate students, or for scientists and researchers entering the field. Established researchers will also find this timely work useful as an up-to-date overview of this fascinating research area.
Perinatal Neuropathology
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Author : Mirna Lechpammer
language : en
Publisher:
Release Date : 2021
Perinatal Neuropathology written by Mirna Lechpammer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Nervous system categories.
"1 Clinical history, clinical correlations with placental pathology and prematurity The initial steps in the process of perinatal nervous system evaluation, namely the planning of the optimal approach and choice of samples to be obtained, are driven by the clinical context. Of key importance are the following data: a. Gestational age at time of demise (if stillborn); or gestational age and postnatal age (if liveborn), for comparison with normative standards of development (see Appendix); b. State of maternal health (age, parity, pre-existing medical conditions or ones appearing during gestation or around the time of delivery, exposure to medications/toxins/infections), and of health of siblings or other family members: - Concerns for inherited (i.e., genetic) conditions, metabolic disorders, congenital infections, etc., may indicate the need for special testing; c. Details of prenatal course, including any imaging, amniocentesis, or monitoring: - Prenatal imaging modalities most commonly consist of transabdominal ultrasonography, generally done at the time of the first prenatal visit (to confirm pregnancy) or more usually in the mid-second-trimester for detection of fetal or placental anomalies"--
The Role Of Apoptosis In Development Tissue Homeostasis And Malignancy
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Author : R.M. Dexter
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Role Of Apoptosis In Development Tissue Homeostasis And Malignancy written by R.M. Dexter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The past five years have witnessed a remarkable development of interest in cell death 'from inside out'. After 30 years of relative obscurity, its quantitative importance in the building and maintenance of normal tissues, the subtle strategies involved in its regulation, and its significance in the pathogenesis of diseases of major social importance are becoming clear. Moreover, because a distinct set of biological events is involved in this death, these events themselves become reason able targets for new pharmacological agents in the treatment of cancer. The articles in this volume summarize the contents of a discussion meeting held at the Royal Society on 23 and 24 February 1994. The authors are a distinguished international group from a variety of disciplines in biology and medicine and hopefully their articles will convey something of the excitement of this fast-moving field. The three organizers are enormously indebted to all the contributors for the enthusiasm with which they delivered their talks, shared in discussion, and finally committed their contributions to these printed pages. We would also like to acknowledge the gracious way in which the Royal Society hosted the meeting, and in particular Mary Manning for making it the trouble-free and enjoyable experience that it was, and Janet Clifford and Simon Gribbin for skillfully managing the editorial processing of this volume. Michael Dexter June 1994 Martin Raff Andrew Wyllie x 1 Death from inside out: an overVIew ANDREW H.
Dermatologic Ultrasound With Clinical And Histologic Correlations
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Author : Ximena Wortsman
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-02
Dermatologic Ultrasound With Clinical And Histologic Correlations written by Ximena Wortsman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-02 with Medical categories.
Significant technological advances have produced equipment that allows imaging of the skin with variable frequency ultrasound in previously unseen detail and provides a range of dynamic data that is currently unmatched by any other technology. Dermatologic Ultrasound with Clinical and Histologic Correlations is a comprehensive introduction to ultrasonography of the skin, nails, and scalp as it relates to the assessment and diagnosis of dermatologic diseases. It provides radiologists, sonographers, dermatologists, and physicians with interest in skin imaging with a concise understanding of the diagnosis of dermatologic conditions through extensive high-resolution gray scale and color Doppler ultrasound images and presents classical correlations of clinical dermatologic lesions with sonographic and histologic findings. Featuring more than 1700 images, this text-atlas provides an excellent starting point in learning about this topic. Featuring contributions from world-renowned authorities in the field of superficial ultrasound imaging, the book reviews the technical considerations relating to color Doppler ultrasound of the skin; surveys the dermatologic entities that can be visualized with ultrasound imaging, such as cutaneous tumors, inflammatory diseases, hemangiomas and vascular malformations, melanoma, nail tumors, scalp diseases and cosmetic conditions; shows common simulators of cutaneous diseases; and discusses protocols for assessing common dermatologic conditions. Inclusion of clinical overviews, tips, and pitfalls enables a better understanding of the pathologies of the disorders and the methodological approach in assessing these entities.
Working Mother
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Author :
language : en
Publisher:
Release Date : 2000-10
Working Mother written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10 with categories.
The magazine that helps career moms balance their personal and professional lives.
Nanozymes Next Wave Of Artificial Enzymes
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Author : Xiaoyu Wang
language : en
Publisher: Springer
Release Date : 2016-07-27
Nanozymes Next Wave Of Artificial Enzymes written by Xiaoyu Wang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-27 with Technology & Engineering categories.
This book describes the fundamental concepts, the latest developments and the outlook of the field of nanozymes (i.e., the catalytic nanomaterials with enzymatic characteristics). As one of today’s most exciting fields, nanozyme research lies at the interface of chemistry, biology, materials science and nanotechnology. Each of the book’s six chapters explores advances in nanozymes. Following an introduction to the rise of nanozymes research in the course of research on natural enzymes and artificial enzymes in Chapter 1, Chapters 2 through 5 discuss different nanomaterials used to mimic various natural enzymes, from carbon-based and metal-based nanomaterials to metal oxide-based nanomaterials and other nanomaterials. In each of these chapters, the nanomaterials’ enzyme mimetic activities, catalytic mechanisms and key applications are covered. In closing, Chapter 6 addresses the current challenges and outlines further directions for nanozymes. Presenting extensive information on nanozymes and supplemented with a wealth of color illustrations and tables, the book offers an ideal guide for readers from disparate areas, including analytical chemistry, materials science, nanoscience and nanotechnology, biomedical and clinical engineering, environmental science and engineering, green chemistry, and novel catalysis.
Macromolecular Protein Complexes Iii Structure And Function
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Author : J. Robin Harris
language : en
Publisher: Springer Nature
Release Date : 2020-11-30
Macromolecular Protein Complexes Iii Structure And Function written by J. Robin Harris and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-30 with Science categories.
This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Brain And Human Body Modeling 2020
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Author : Sergey N. Makarov
language : en
Publisher: Springer Nature
Release Date : 2021
Brain And Human Body Modeling 2020 written by Sergey N. Makarov and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Biomedical engineering categories.
The 41st Annual International Conference of the IEEE EMBS, took place between July 23 and 27, 2019, in Berlin, Germany. The focus was on "Biomedical engineering ranging from wellness to intensive care." This conference provided an opportunity for researchers from academia and industry to discuss a variety of topics relevant to EMBS and hosted the 4th Annual Invited Session on Computational Human Models. At this session, a bevy of research related to the development of human phantoms was presented, together with a substantial variety of practical applications explored through simulation.
Stress And Mental Disorders
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Author : Richard McCarty
language : en
Publisher: Oxford University Press, USA
Release Date : 2020
Stress And Mental Disorders written by Richard McCarty and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Medical categories.
Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.