Contemporary Challenges In Immunologic Testing In Clinical And Research Laboratories
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Contemporary Challenges In Immunologic Testing In Clinical And Research Laboratories
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Author : Pablo Engel
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-24
Contemporary Challenges In Immunologic Testing In Clinical And Research Laboratories written by Pablo Engel and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-24 with Medical categories.
Along the last several decades, it has been progressively appreciated that immunology plays an overwhelming role in the physiology and pathophysiology of most organs, tissues, and biological systems in multicellular organisms. Accordingly, several immunological parameters are used in research and clinical laboratories with the purpose of investigating, diagnosing, and monitoring a variety of pathological conditions. The rapidly evolving field of laboratory testing in immunology poses several challenges to professionals working in research and clinical laboratories, medical practice, educational activities, in vitro diagnostic industry, and regulatory agencies. Regular analytes, such as albumin, glucose, and insulin, are homogeneous among individuals of the same species. This property represents an advantage when it comes to optimize the determination methods as well as to establish standardization and quality assessment strategies. In contrast, several immunologic analytes present tremendous variability across individuals in the same species. In fact, some are unique at the individual level. For example, the repertoire of immunoglobulins specific for a given pathogen (e.g., rubella) is specific for each individual in terms of the balance of targeted antigens and epitopes, immunoglobulin isotypes, antibody avidity, Fc glycosylation rate, and so on. As a corollary, the panel of anti-rubella antibodies is necessarily different from one to other individual. This also applies to autoantibodies and to IgE to allergens. Polymorphism is prevalent for other immunologic parameters, such as Complement components, cell receptors (cluster differentiation molecules - CD) and downstream signal transduction mediators.
The Present And Future Of Immunology Education
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Author : Andrea Bottaro
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-24
The Present And Future Of Immunology Education written by Andrea Bottaro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-24 with Medical categories.
The explosion of basic and applied immunology in the first decades of the 21st century has brought forth new opportunities and challenges for immunology education at all academic levels, from professional to undergraduate, medical, graduate and post-graduate instruction. Moreover, developing methods and techniques for educating general audiences on the importance and benefits of immunology will be critical for increasing public awareness and support. One major immediate challenge consists in accommodating, within the confines of traditional immunology curricula, a body of knowledge that continues to grow exponentially in both size and complexity. Furthermore, the practical toolbox of immunological research has vastly expanded, and even in the present environment of highly interdisciplinary and collaborative science, future immunologists will likely need to be at least conversant in, for instance, computational, structural and system biology, nanotechnology and tissue engineering. At the same time, our perspective of the immune system has progressively developed from primarily a host defense mechanism to a fundamental homeostatic system with organism-wide physiological and clinical significance, and with potentially transformative biotechnological and therapeutic applications. As a consequence, in addition to stand-alone courses, immunology is increasingly integrated into other courses, or distributed longitudinally, throughout a multi-year curriculum. This necessitates inter-disciplinary approaches to reach an expanding range of disciplines, as diverse as neurobiology, cancer biology/ oncology, infectious diseases, pharmacology, orthopedics and bioengineering. Creative approaches and pedagogical flexibility will be needed to avoid the pitfall of “one-size-fits-all” instruction, and to tailor level- and discipline-appropriate content to different types of students using multiple teaching formats. Finally, like most other disciplines, immunology education is also under strong pressure to introduce new didactic strategies that are relevant and meaningful to a generation of students who are “digital natives”, comfortable with and expect on-demand and multi-modal learning, diversified sources, and active engagement. Thankfully, the dynamic and interactive behavior of immune system cells, now visualized with striking immediacy by in vivo imaging, has the ability to capture and hold the interest of even the most jaded learner. The need for an increasingly immunology-knowledgeable workforce – not just academic and industry scientists, but also clinical and research lab technicians, biomedical engineers, and physicians in a growing array of specialties - will also expand job opportunities for immunologists as educators, and for content creators dedicated to generating new didactic tools in this field. Acknowledgement: We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS).
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1989
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medicine categories.
Subject Index Of Current Research Grants And Contracts Administered By The National Institute Of General Medical Sciences
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Author : National Institute of General Medical Sciences (U.S.)
language : en
Publisher:
Release Date : 1976
Subject Index Of Current Research Grants And Contracts Administered By The National Institute Of General Medical Sciences written by National Institute of General Medical Sciences (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Medicine categories.
Subject Index Of Current Research Grants And Contracts Administered By The National Institute Of General Medical Sciences
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Author : National Institute of General Medical Sciences (U.S.). Division of Research Grants
language : en
Publisher:
Release Date : 1976
Subject Index Of Current Research Grants And Contracts Administered By The National Institute Of General Medical Sciences written by National Institute of General Medical Sciences (U.S.). Division of Research Grants and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Medicine categories.
Scientific Foundations Of Ophthalmology
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Author : Edward S. Perkins
language : en
Publisher: Butterworth-Heinemann
Release Date : 2013-10-22
Scientific Foundations Of Ophthalmology written by Edward S. Perkins and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Scientific Foundations of Ophthalmology focuses on scientific grounds of ophthalmology, including anatomy, genetics, pathology, and epidemiology of blindness and blinding diseases. The selection first offers information on aqueous outflow pathway in vertebrate eyes; retinal receptors and pigment epithelium; and vascular supply of the optic disc. Discussions focus on glaucomatous cupping of the optic disc, venous drainage, receptor synapses, outer plexiform layer, primates, and lower mammals. The book then ponders on anatomical and neurophysiological review of cerebral control of ocular movements and the structure and transparency of the cornea. The publication elaborates on the biochemistry of lens, regulation of retinal blood flow, and biochemical basis of toxic amblyopias. The text also takes a look at the hereditary aspects of glaucoma, inborn errors of metabolism, retinal dystrophies, and gyrate atrophy of the choroid and retina with hyperornithinaemia. Vitreoretinal degenerations in myopia, retinitis pigmentosa, albinism, lens dislocation, and storage disorders involving complex lipids and carbohydrates are discussed. The selection is highly recommended for ophthalmologists and readers interested in ophthalmology.
Manual Of Molecular And Clinical Laboratory Immunology
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Author : Barbara Detrick
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-16
Manual Of Molecular And Clinical Laboratory Immunology written by Barbara Detrick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-16 with Medical categories.
THE authoritative guide for clinical laboratory immunology For over 40 years the Manual of Molecular and Clinical Laboratory Immunology has served as the premier guide for the clinical immunology laboratory. From basic serology testing to the present wide range of molecular analyses, the Manual has reflected the exponential growth in the field of immunology over the past decades. This eighth edition reflects the latest advances and developments in the diagnosis and treatment of patients with infectious and immune-mediated disorders. The Manual features detailed descriptions of general and specific methodologies, placing special focus on the interpretation of laboratory findings, and covers the immunology of infectious diseases, including specific pathogens, as well as the full range of autoimmune and immunodeficiency diseases, cancer, and transplantation. Written to guide the laboratory director, the Manual will also appeal to other laboratory scientists, especially those working in clinical immunology laboratories, and pathologists. It is also a useful reference for physicians, mid-level providers, medical students, and allied health students with an interest in the role that immunology plays in the clinical laboratory.
Handbook Of Human Immunology
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Author : Mary S. Leffell
language : en
Publisher: CRC Press
Release Date : 1997-04-10
Handbook Of Human Immunology written by Mary S. Leffell and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-04-10 with Medical categories.
Combining basic explanations of laboratory tests with 115 tables full of reference data and applications, the Handbook of Human Immunology provides practicing clinicians with a current, complete guide to molecular immunology. Introductory chapters overview the molecular basis of immune responses and immunological disorders, focusing on the role of cell receptors, accessory molecules, and cytokines in these processes. Emphasis is placed on immunological parameters that are clinically useful. The basic principles underlying assays of the immune system are discussed, and the book stresses the application and interpretation of immune tests. Comprehensive coverage is given to immunoglobulins and their age-dependent concentration. Cellular immunology is discussed from the perspectives of lymphocyte functional parameters, as well as through immunophenotyping of lymphocytes and other leukocytes. Both serological and molecular diagnosis of infectious diseases are reviewed. The Handbook of Human Immunology contains up-to-date information on exciting developments in immunogenetics, covering the application of T-cell receptor genes and the HLA alleles in disease associations and transplantation.
Immunology Laboratory Testing An Issue Of The Clinics In Laboratory Medicine
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Author : Vinay Subash Mahajan
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-11-02
Immunology Laboratory Testing An Issue Of The Clinics In Laboratory Medicine written by Vinay Subash Mahajan and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-02 with Medical categories.
This issue of Clinics in Laboratory Medicine, guest edited by Dr. Vinay Subhash Mahajan, will focus on Immunology Laboratory Testing. Topics include, but are not limited to, Analysis of proteins and immunoglobulins in the clinical immunology laboratory; Antinuclear antibody tests; Serological diagnosis of rheumatoid arthritis; ANCA; Anti-phospholipid antibodies; Diagnostic pitfalls in autoantibody testing; Analysis of the complement pathway; Flow cytometric analysis of immune cell subsets; Testing of cellular immune function in immunodeficiencies; Food allergy testing; Evaluation of the immune response in transplantation; Laboratory testing in the context of biologics and cellular therapies; Testing immune-related adverse-events in cancer immunotherapy; Molecular diagnosis of inherited immune disorders; and Future of immunology lab testing.
Issues In Allergy And Asthma Research And Treatment 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Issues In Allergy And Asthma Research And Treatment 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Issues in Allergy and Asthma Research and Treatment: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Allergy and Asthma Research and Treatment. The editors have built Issues in Allergy and Asthma Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Allergy and Asthma Research and Treatment in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Allergy and Asthma Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.