Copeland And Afshari S Principles And Practice Of Cornea
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Copeland And Afshari S Principles And Practice Of Cornea
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Author : Robert A Copeland Jr
language : en
Publisher: JP Medical Ltd
Release Date : 2013-02-28
Copeland And Afshari S Principles And Practice Of Cornea written by Robert A Copeland Jr and has been published by JP Medical Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-28 with Medical categories.
The cornea is the transparent front part of the eye covering the iris and the pupil, allowing light to enter and covering two thirds of the eye’s focusing tasks. This two volume set is a comprehensive guide to the latest research and techniques for the cornea. Beginning with basic science, examination techniques and epidemiology, the following chapters discuss the diagnosis and the medical and surgical treatment of numerous different conditions and diseases that may affect the cornea. Written by an extensive international editor and author team, this manual features more than 1300 full colour clinical and histopathological images, as well as a DVD demonstrating a multitude of surgical techniques described in the book. Key points Comprehensive two volume set describing diagnosis and treatment of numerous corneal disorders Features more than 1300 colour images and illustrations Includes a DVD demonstrating surgical techniques and procedures Extensive international author and editor team
Inhibitors Of Corneal Inflammation And Angiogenesis
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Author : Pierfrancesco Mirabelli
language : en
Publisher: Linköping University Electronic Press
Release Date : 2019-04-30
Inhibitors Of Corneal Inflammation And Angiogenesis written by Pierfrancesco Mirabelli and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-30 with categories.
Pathologic angiogenesis is involved in cancer and several blinding conditions such as wet age-related macular degeneration, proliferative retinopathies and corneal neovascularization. In these dieseases, the angiogenic triggers are hypoxia and inflammation, and both involve the main angiogenic mediator, which is Vascular Endothelial Growth Factor (VEGF). Among available treatments, anti-VEGF often shows limited or temporary efficacy, while steroids are potentially responsible for many side-effects. This thesis presents a series of linked studies aimed at elucidating the early pathologic changes leading to inflammation and corneal neovascularization, and how various treatments affect this process. In this thesis, anti-inflammatory and anti-angiogenic treatments are applied in corneal neovascularization models, to identify VEGF-independent pathways and other novel factors as future therapy targets, as well as to investigate the endogenous modulation of angiogenesis. A model of experimental neovascularization in the rat cornea was used as main model, where the neovascular response is triggered by a surgical suture placed into the cornea. Investigational treatments (anti-Vegf, dexamethasone, IMD0354, Gap27, or control substances) were then given topically, with the exception of IMD0354, which was given systemically. The effects in the cornea were studied in vivo with slit lamp photography to assess and quantify macroscopic vessel growth and using in vivo confocal microscopy (IVCM) to study cell infiltration and limbal vessel dilation and detect microscopic vessel sprouts; these examinations were performed longitudinally. Genomic analysis with RNA microarray, selected gene expression with q-RT-PCR, and selected protein expression in tissue (immunohistochemistry, immunofluorescence, Western blot) were performed at different time-points. Moreover, other experiments on cell cultures (HUVEC and HCEC), organ cultures (human corneas), ex vivo models (aortic rings) and in vivo studies (zebrafish vasculogenesis) were performed. Dexamethasone suppressed limbal vasodilation and corneal neovascularization more than anti-Vegf, despite no difference in inflammatory cell infiltration into the cornea. Five-hundred eleven fewer genes were differentially expressed in dexamethasone-treated corneas relative to naïve corneas, compared to anti-Vegf. Among them, several major pro-angiogenic and pro-inflammatory factors and chemokines were suppressed only by dexamethasone and represent novel candidate factors to target in order to improve anti-VEGF treatment. On the other hand, selective inhibition of a single inflammatory pathway (NF-?B), despite showing similar early effects as dexamethasone in suppressing tissue inflammation, was not effective enough to suppress new vessel growth. The same factors suppressed by dexamethasone are also inhibited in endogenous modulation of angiogenesis. Surprisingly, dexamethasone activated several complement factors, which could possibly be beneficial in the anti-angiogenic response. In a different therapeutic approach, promoting cell migration to accelerate epithelial wound closure similarly was not sufficient to avoid inflammation and angiogenesis in the cornea. In conclusion, new and more effective treatments are needed for corneal inflammation and neovascularization with fewer side-effects. In this thesis, several novel factors and mechanisms related to inflammation are identified, factors that are not addressed by anti-Vegf therapy, and therefore represent interesting objects for further study, as they have the potential to be targets for adjuvant therapy. Specific anti-inflammatory treatment as well as therapeutic activation of endogenous regulatory pathways, and potentially complement modulation, might represent new strategies to improve anti-angiogenic therapy, but when used alone they do not seem to avoid corneal neovascularization.
Practical Cytopathology
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Author : Huihong Xu
language : en
Publisher: Springer Nature
Release Date : 2019-10-31
Practical Cytopathology written by Huihong Xu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-31 with Medical categories.
This book provides a comprehensive, practical, and state-of-the art review addressing the major issues and challenges in cytopathology practice using a question and answer format. Making an accurate diagnosis, especially on a limited cytology sample obtained by minimally invasive procedures, is often challenging, yet crucial to patient care. Using the most current and evidence-based approaches, this book: 1) focuses on frequently asked questions in day-to-day practice of cytopathology as well as surgical pathology; 2) provides quick, accurate, and useful answers; 3) emphasizes the importance of clinical, radiological, and cytological correlation, as well as cyto-histological correlation; and 4) delineates how to judiciously use immunohistochemistry, molecular tests, flow cytometry, cytogenetics, and other established ancillary studies including next generation sequencing and computer-assisted diagnostics. Chapters are written by experts in their fields and provide the most up-to-date information in the field of cytopathology. Practical Cytopathology: Frequently Asked Questions serves as a practical resource and guide to relevant references for trainees, cytotechnologists, and cytopathologists at various skill levels.
Refractive Surgery
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Author : Howard V. Gimbel
language : en
Publisher: Slack
Release Date : 2000
Refractive Surgery written by Howard V. Gimbel and has been published by Slack this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Cornea categories.
Drs. Gimbel and Penno provide a comprehensive look at a wide variety of refractive surgery techniques in their new book. Specific techniques are discussed along with preoperative assessments, counseling, and informed consent. In addition to chapters on the commonly performed techniques of LASIK and PRK, there are chapters on intracorneal ring segments, phakic IOL implants, refractive lensectomy, and retreatments. The authors take a practical and concise approach to a wide scope of modern refractive surgery techniques which makes this reference valuable for both the experienced and beginning surgeon. Patient examples are featured illustrating the fundamental principles of assessment and choosing the appropriate refractive surgery technique for an individual patient. The inclusion of co-management principles emphasizes integrated care during the assessment and preoperative work-up, as well as during the postoperative period. This book is an important source that covers many refractive surgery approaches to help you choose the best procedure for your patients and achieve the best results possible.
Gems Of Ophthalmology Cornea Sclera
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Author : HV Nema
language : en
Publisher: JP Medical Ltd
Release Date : 2018-06-30
Gems Of Ophthalmology Cornea Sclera written by HV Nema and has been published by JP Medical Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-30 with Medical categories.
Part of the new series Gems of Ophthalmology, this book provides the latest information in the diagnosis and management of diseases of the cornea and sclera. Beginning with an overview of corneal topography, the following chapters compare LASIK and SMILE procedures for refractive surgery, and their potential complications. The remaining sections discuss numerous disorders, covering both common conditions and more complex, less common infections such as fungal keratitis and acanthamoeba keratitis. Corneal dystrophies and their latest classification and management are explained in depth, as is DALK (Deep Anterior Lamellar Keratoplasty). A chapter on corneal changes in contact lens wearers, is also included. This comprehensive text is further enhanced by clinical and surgical photographs. Other topics in the series include: Diseases of the Uvea, Glaucoma, and Retina. Key points Comprehensive guide to diagnosis and management of diseases of the cornea and sclera Part of the new Gems of Ophthalmology series Covers many common and more complex disorders and infections Other topics in the series include: Diseases of the Uvea, Glaucoma, and Retina
Diagnosis And Surgical Therapy Of Infantile Corneal Opacities
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Author : Sarah Barbara Zwingelberg
language : en
Publisher: Springer Nature
Release Date :
Diagnosis And Surgical Therapy Of Infantile Corneal Opacities written by Sarah Barbara Zwingelberg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Textbook On Clinical Ocular Pharmacology Therapeutics
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Author : Renu Agarwal
language : en
Publisher: JP Medical Ltd
Release Date : 2014-09-30
Textbook On Clinical Ocular Pharmacology Therapeutics written by Renu Agarwal and has been published by JP Medical Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-30 with Medical categories.
This book is a comprehensive guide to ocular pharmacology for trainees and practising ophthalmologists. Beginning with the basic physiological aspects of ocular pharmacology and ophthalmic drug administration, the following sections discuss different types of drugs used in the treatment of eye disease. The final sections examine contact lens care systems, nutritional supplements and adverse effects of systematically administered drugs into the eye. This useful, quick reference text is highly illustrated with more than 145 images and tables. Key points Comprehensive guide to ocular pharmacology for trainees and practising ophthalmologists Covers different drugs for treatment of eye diseases Includes section on adverse effects of systematically administered drugs Highly illustrated with more than 145 images and tables
Cornea E Book
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Author : Mark J Mannis
language : en
Publisher: Elsevier Health Sciences
Release Date : 2016-09-23
Cornea E Book written by Mark J Mannis and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-23 with Medical categories.
Highly praised in its first three editions, Cornea has become a market-leading cornerstone text and the immediate go-to resource for anyone working in this hugely popular and evolving sub-specialty. Offered over two volumes and featuring the knowledge of over 200 experts worldwide, it presents state-of-the-art coverage of the expanding range of contemporary corneal surgery, new diagnostic technology, and medical management of corneal and external disease as well as ocular surface disease. This updated edition includes 20 brand-new chapters, while an enhanced focus on images provides key visual guidance in this challenging field. Exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs offer superb visual guidance. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos, and references from the book on a variety of devices. 20 brand-new chapters cover the latest advances in the field, such as DMEK, Ultra-Thin DSEK and DSAEK techniques; endothelial cell transplantation; keratoplasty and prosthokeratoplasty techniques; collagen cross-linking; and new refractive surgical techniques (presbyopic implants and SMILE surgery). 60 video clips on Expert Consult show new footage of the latest corneal surgery techniques, including Boston Keratoprosthesis, corneal inlay surgery, and lenticule extraction. Boasts over 170 chapters with unique, cutting-edge content, as well as 2,300 clear illustrations – 670 of which are new to this edition. Presents a detailed exposition of the growing number of techniques for lamellar keratoplasty, including outcomes. Includes new sections on the latest developments in the management of ocular surface disease. Key point overviews in each chapter offer easier access to crucial information.
Peyman S Principles And Practice Of Ophthalmology
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Author : N. VENKATESH. PRAJNA
language : en
Publisher:
Release Date : 2018
Peyman S Principles And Practice Of Ophthalmology written by N. VENKATESH. PRAJNA and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Eye categories.
Principles And Practice Of Refractive Surgery
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Author : Richard Elander
language : en
Publisher: Saunders
Release Date : 1997
Principles And Practice Of Refractive Surgery written by Richard Elander and has been published by Saunders this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
Introducing the first comprehensive textbook covering all aspects of refractive surgery. Provides the reader with a broad, in-depth description of the principles, theories, methods, instrumentation, and economics involved with incisional, lamellar, and laser surgery correction of refractive errors. Includes contributions from international authorities, and provides comprehensive coverage of currently available instrumentations.