Coronavirus Drug Discovery
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Coronavirus Drug Discovery
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Author : Chukwuebuka Egbuna
language : en
Publisher: Elsevier
Release Date : 2022-07-06
Coronavirus Drug Discovery written by Chukwuebuka Egbuna and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-06 with Medical categories.
Coronavirus Drug Discovery, Volume Three: Druggable Targets and In Silico Update presents comprehensive information on drug discovery against COVID-19. Chapters in Part One of this volume describe the various druggable targets and associated signaling pathways for effective targeting of SARS-CoV-2. In Part Two, chapters discuss the various computational approaches and in silico studies against SARS-CoV-2. Written by global team of experts, this book is an excellent resource that will be extremely useful to drug developers, medicinal chemists, pharmaceutical companies in R&D, research institutes in both academia and industry, and the National Library of Medicines and Health. In addition, agencies such as the National Institutes of Health, Centers for Disease Control and Prevention, World Health Organization, European Medicines Agency, the US Food and Drug Administration, and all others involved in drug discovery against COVID-19 will find this book useful. Discusses the pathogenic mechanisms of SARS-CoV-2 and druggable targets Reviews the various signaling pathways associated with SAR-CoV-2 as possible druggable targets Presents computational approaches and in silico studies against SARS-CoV-2
Coronavirus Drug Discovery
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Author : Chukwuebuka Egbuna
language : en
Publisher: Elsevier
Release Date : 2022-05-25
Coronavirus Drug Discovery written by Chukwuebuka Egbuna and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-25 with Science categories.
Coronavirus Drug Discovery, Volume 1: SARS-CoV-2 (COVID-19) Prevention, Diagnosis, and Treatment is the first of three volumes presenting comprehensive information on drug discovery against COVID-19. This volume provides background information on the genesis of COVID-19, the epidemiology, transmission, pathogenesis, and mutagenesis. It also presents the various treatment options, drug discovery opportunities and vaccine developmental processes. Written by global team of experts from key institutions across the globe, this book is recommended to all concerned agencies, private research firms, and consortiums working on finding a solution to COVID-19 and its variants. By design, this book will be useful to drug developers, medicinal chemists, pharmacologists, health experts, researchers, students and faculty members in industry and academia. Presents information on the genesis of COVID-19, global impact and collaborative efforts Details the epidemiology, transmission, pathogenesis, and mutagenesis of SARS-CoV-2 Documents the various treatment options and vaccine development for COVID-19
Coronavirus Drug Discovery
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Author : Chukwuebuka Egbuna
language : en
Publisher: Elsevier
Release Date : 2022-07-07
Coronavirus Drug Discovery written by Chukwuebuka Egbuna and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-07 with Science categories.
Coronavirus Drug Discovery, Volume Two: Antiviral Agents from Natural Products and Nanotechnological Applications presents detailed information on drug discovery against COVID-19. Sections in this volume present chapters that focus on the various antiviral agents from natural products that have the propensity to be used as chemical scaffolds for the development of drugs against COVID-19. Also captured are the dietary sources of antioxidant bioactives that may help boost the immune system for the management of COVID-19. Other chapters describe the application of nanotechnology for efficient and effective delivery of drugs against COVID-19. Written by global team of experts, this book is an excellent resource for drug developers, medicinal chemists, pharmaceutical companies in R&D and research institutes in both academia and industry. Presents the various antiviral bioactive compounds from natural products Discusses the roles of antioxidant in the prevention and management of COVID-19 Details the application of nanotechnology for efficient and effective drug delivery
Exscalate4cov
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Author : Silvano Coletti
language : en
Publisher: Springer Nature
Release Date : 2023-05-02
Exscalate4cov written by Silvano Coletti and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-02 with Technology & Engineering categories.
This book highlights the different aspects of the research project “E4C Horizon 2020 European Project” aimed at fighting the coronavirus by combining the best supercomputing resources and artificial intelligence with state-of-the-art experimental facilities up through clinical validation. Coronavirus disease has become an important public issue across the globe since December 2019. There is an urgent need to develop potent anti-COVID-19 agents for the prevention of the outbreak and stop viral infections. To this aim, a public–private consortium composed by European and national infrastructures, center of excellence, universities, and a pharmaceutical company started the E4C Horizon 2020 European Project: Its core idea was to use the EXaSCale smArt pLatform Against paThogEns (EXSCALATE) supercomputing platform for a process known as “drug repurposing”, namely to identify the most promising safe in man drugs for immediate treatment of the already infected population and then novel pan-coronavirus inhibitors to address future emergencies. This ambitious goal exploited a “chemical library” of 500 billion molecules, thanks to a processing capacity of more than 3 million molecules per second, made available by the computing power of the EXSCALATE platform.
Novel Coronavirus 2019
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Author : Amit Kumar
language : en
Publisher: Springer Nature
Release Date : 2020-09-26
Novel Coronavirus 2019 written by Amit Kumar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-26 with Science categories.
This book highlights the genomic findings, observations, and analysis of DNA/RNA sequences and protein structure of the dreadful virus of this decade- COVID-19. The Corona group of viruses though known species, the strain that caused the Pandemic of 2019 is a completely new strain, belonging to the same corona family with a novel genetic make-up. This makes it a new pathogen which is causing the current outbreak leaving the global scientific community clueless of any therapeutic breakthrough. NCOV enjoys life threatening pathogenicity with mysterious genetic annotations. This book details and offers insights into its viral genetic arrangement, Virulence factors, probable mutations leading to the evolution of this new strain and more. It contains chapters on Virus evolutionary status and Genetic makeup leading to its pathogenicity which can be a new insight in understanding the nature of this clever microorganism and can pave way to the development of new drugs and Vaccines or a novel diagnostic approach for the early prognosis of the disease. A dedicated chapter on annotation of NCOV-19 virulence genes, translation of the genes to protein product, annotation of the antigenic sites on these proteins is also included. In all, this brief is a complete genomic annotation insight of NCOV-19 using AI, Data analytics and Bioinformatics analysis. In the current situation, this book is an extensive preliminary resource for Medical practitioners, Researchers, Academicians, Scientists, Biochemists, Bioinformaticians and other professionals interested in understanding the genetics of Novel Coronavirus 19, the best possible drug targets, ideal vaccine candidates and novel prognostic and diagnostic biomarkers.
Coronavirus Therapeutics Volume I
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Author : Alexzander A. A. Asea
language : en
Publisher: Springer Nature
Release Date : 2022-02-24
Coronavirus Therapeutics Volume I written by Alexzander A. A. Asea and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-24 with Medical categories.
The book Coronavirus Therapeutics Volume I provides the most comprehensive review on contemporary knowledge on the origin and structural biology and molecular aspects of Coronaviruses. This also describes the etiology and pathogeny and therapeutic targets including vaccine drug candidates against Coronaviruses in the light of current scientific knowledge. Using an integrative approach to the understanding of Coronaviruses structure, function and immunobiology, the contributors provide a synopsis of novel mechanisms by which Coronaviruses can be treated. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Ethnopharmacology And Drug Discovery For Covid 19 Anti Sars Cov 2 Agents From Herbal Medicines And Natural Products
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Author : Jen-Tsung Chen
language : en
Publisher: Springer Nature
Release Date : 2023-10-09
Ethnopharmacology And Drug Discovery For Covid 19 Anti Sars Cov 2 Agents From Herbal Medicines And Natural Products written by Jen-Tsung Chen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-09 with Medical categories.
This book presents a complete overview of COVID-19 and provides a series of in-depth analyses of the literature and a comprehensive discussion and perspectives on promising anti-SARS-CoV-2 agents based on the system of ethnopharmacology, which covers Chinese medicine, traditional medicines of India and Africa, Turkish folk medicine, essential oils, and some well-known medicinal plants. In this book, the current status of therapeutic strategies against COVID-19 was summarized and a perspective of potential options for the future was proposed. Based on ethnopharmacology, some well-established traditional herbal formulations and bioactive compounds with anti-virus activity were repurposed for managing COVID-19 and post-illness, including neurological disorders and kidney illness. Using drug discovery tools, promising immune enhancers were explored from phytochemicals against SARS-CoV-2. Nutraceuticals from dietary plants, spices, and fruits with anti-virus and antioxidant activities were recommended to prevent infection or severe illness caused by emerging variants. With the aid of systems pharmacology, researchers have gained insights into possible molecular mechanisms of anti-SARS-CoV-2 activity and have predicted a range of candidate compounds from medicinal plants to combat COVID-19. This book explores the current knowledge of drug discovery and ethnopharmacology for managing coronavirus diseases. The content proved the anti-SARS-CoV-2 activity from natural products and traditional herbal medicines. It contributes to the management of global public health and fits the goal of establishing “Good Health and Well-Being,” which is one of “The Sustainable Development Goals (SDGs) 2030".
Coronavirus Therapeutics Volume Ii
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Author : Alexzander A. A. Asea
language : en
Publisher: Springer Nature
Release Date : 2022-02-08
Coronavirus Therapeutics Volume Ii written by Alexzander A. A. Asea and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-08 with Medical categories.
The book Coronavirus Therapeutics Volume II provides the most comprehensive review on contemporary knowledge on the consequences during the outbreak of Coronavirus. This also describes the clinical features, diagnostic evaluation and management of Coronavirus patients. Using an integrative approach to the understanding of paradigm gap in host-pathogen interaction studies to the management of Coronavirus patients in the Intensive Care Unit to the current challenges for the effective management of Coronavirus pandemic risk factors including diabetes, hypertension, obesity and repercussion on the central and peripheral nervous system. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Modeling Control And Drug Development For Covid 19 Outbreak Prevention
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Author : Ahmad Taher Azar
language : en
Publisher: Springer Nature
Release Date : 2021-11-01
Modeling Control And Drug Development For Covid 19 Outbreak Prevention written by Ahmad Taher Azar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-01 with Computers categories.
This book is well-structured book which consists of 31 full chapters. The book chapters' deal with the recent research problems in the areas of modeling, control and drug development, and it presents various techniques of COVID-19 outbreak prevention modeling. The book also concentrates on computational simulations that may help speed up the development of drugs to counter the novel coronavirus responsible for COVID-19. This is an open access book.
Development Of Covid 19 Therapies Lessons Learnt And Ongoing Efforts
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Author : Bruno Villoutreix
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-24
Development Of Covid 19 Therapies Lessons Learnt And Ongoing Efforts written by Bruno Villoutreix and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-24 with Science categories.
Massive experimental, computational, and clinical studies have been performed worldwide, and are still ongoing, to understand and characterize Covid-19 molecular basis and transmission mechanisms, to develop diagnostics and vaccines, and to search for small chemical drug candidates and therapeutic proteins and peptides. Impressive results have been obtained for transmission control and vaccines so far, but what is the status of the other therapeutic options? The crisis has exposed different types of weaknesses in biomedical research in many countries. What can we learn from this crisis in the field of drug discovery and development so as to emerge stronger? The Covid-19 crisis has revealed the strengths of modern drug discovery and vaccine development but also exposed different types of weaknesses that would need to be addressed to be better prepared for a possible next global health crisis. These challenges/weaknesses/obstacles are of very different nature and as such hard to tackle. For instance, in addition to the inherent challenging nature of the scientific discovery, some scientists have mentioned insufficient local/national coordination and observed a fragmented drug discovery research, others have underlined a lack of coordination between the academic system and the private sector, an inadequate international global coordination and cooperation, others highlighted insufficient infrastructures, inappropriate financial supports, limited discussions between the scientific community performing the research and the public health authorities, decision makers and the society, while some remarked insufficient education/training about drug discovery and development leading to confusion… The crisis also raised important scientific questions about the technologies that would need to be used during an emergency situation, combined, integrated, or developed so as to accelerate the identification of small molecule drug candidates and of therapeutic peptides/proteins.