Coupling Of Capillary Electrophoresis With Nuclear Magnetic Resonance Spectroscopy For The Analysis Of Pharmaceutical And Environmental Relevant Compounds
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Coupling Of Capillary Electrophoresis With Nuclear Magnetic Resonance Spectroscopy For The Analysis Of Pharmaceutical And Environmental Relevant Compounds
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Author : Joana Diekmann
language : en
Publisher: GRIN Verlag
Release Date : 2011-03-21
Coupling Of Capillary Electrophoresis With Nuclear Magnetic Resonance Spectroscopy For The Analysis Of Pharmaceutical And Environmental Relevant Compounds written by Joana Diekmann and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-21 with Science categories.
Master's Thesis from the year 2009 in the subject Chemistry - Analytical Chemistry, grade: 1,0, University of Hannover (Anorganische Chemie), language: English, abstract: Separation and identification of mass-limited chemical samples is the key to understand the complex nature of pharmaceutical and environmental systems. High efficiency separation techniques, such as capillary electrophoresis (CE), coupled to a non-destructive, information-rich detection, such as nuclear magnetic resonance (NMR) spectroscopy, have revolutionized the ability to separate and identify components in small sample volumes. Using this hyphenated system, structure elucidation of analytes separated during an electrophoretic process can be performed using NMR as an on-line detector. Although sensitivity remains an issue for on-line NMR detection, capillary NMR spectroscopy using microcoils has emerged as a major breakthrough for increasing the mass-sensitivity of NMR spectroscopy, because the limit of detection is proportional to the coil diameter. A further development is the miniaturization of the magnet enabling the possibility of a truly portable NMR system. This portable, low-cost NMR sensor, coupled to the rapid CE separation system could enable high-throughput and on-site identification of nanoliter amounts of solution. Furthermore, CE can provide on-line pre-concentration via electrokinetic injection or other stacking techniques to increase the sample concentration. In this research, coupling CE to a laboratory-scale NMR and to a portable NMR system are investigated, with the emphasis on the development of the miniaturized system. For the experiments with the large-scale 1H NMR system, a group of selected uric acids and xan- thines are studied since those compounds are representative of various classes of therapeutical drugs. The portable NMR instrument incorporates lithographically patterned microcoils and a small 1.8 T permanent magnet to measure 19F NMR spectra for the analysis of trifluoroacetic acid (TFA) and longer chain perfluorinated carboxylic acids (PFCAs). Our results demonstrate that coupling CE to a portable NMR system is feasible and can provide a low cost method to obtain structural information about the samples of interest. The results confirm that it was possible to acquire congruent sample data using the ultraviolet/visible (UV/VIS) detector of the CE and the 19F NMR detector. To obtain data, CE and NMR conditions were optimized and different modes of data acquisition were investigated.
Coupling Of Capillary Electrophoresis With Nuclear Magnetic Resonance Spectroscopy For The Analysis Of Pharmaceutical And Environmental Relevant Compo
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Author :
language : en
Publisher: GRIN Verlag
Release Date :
Coupling Of Capillary Electrophoresis With Nuclear Magnetic Resonance Spectroscopy For The Analysis Of Pharmaceutical And Environmental Relevant Compo written by and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Capillary Electrophoresis Mass Spectrometry Ce Ms
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Author : Gerhardus de Jong
language : en
Publisher: John Wiley & Sons
Release Date : 2016-06-16
Capillary Electrophoresis Mass Spectrometry Ce Ms written by Gerhardus de Jong and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-16 with Science categories.
This monograph offers the reader a complete overview on both principles and applications of CE-MS. Starting with an introductory chapter on detection in CE, also related and more specialized techniques such as electrophoretic and chromatographic preconcentration are discussed. A special emphasis is put on CE-MS interfaces, which are described in detail. In a separate chapter, attention is paid to sheath-liquid interfacing. The developments and possibilities of microchip CE-MS are also described. Applications to all relevant areas are discussed in distinct chapters, each written by experts in the respective fields. Besides applications in pharmaceutical analysis and bioanalysis, recent implementations in food science, forensic analysis, analysis of intact proteins, metabolomics and proteomics are highlighted. MS is a perfectly appropriate detection system for CE, as efficient separation is coupled to sensitive and selection detection. Moreover, MS can provide structure information on the separated compounds. CE-MS has now been developed into a strong hyphenated system complementary to LC-MS. This monograph is an unique source of knowledge for everyone dealing with and interested in CE-MS.
Capillary Electrophoresis Methods For Pharmaceutical Analysis
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Author : Satinder Ahuja
language : en
Publisher: Elsevier
Release Date : 2011-08-09
Capillary Electrophoresis Methods For Pharmaceutical Analysis written by Satinder Ahuja and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-09 with Medical categories.
Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control. - Provides current status and future developments in CE analysis of pharmaceuticals. - Explains how to develop and validate methods. - Includes major pharmaceutical applications including assays and impurity testing.
Capillary Electrophoresis
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Author : Suvardhan Kanchi
language : en
Publisher: CRC Press
Release Date : 2017-08-21
Capillary Electrophoresis written by Suvardhan Kanchi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-21 with Medical categories.
Capillary electrophoresis (CE) has become an established method with widespread recognition as an analytical technique of choice in numerous analytical laboratories, including industrial and academic sectors. Pharmaceutical and biochemical research and quality control are the most important CE applications. This book provides a comparative assessment of related techniques on mode selection, method development, detection, and quantitative analysis and estimation of pharmacokinetic parameters and broadens the understanding of modern CE applications, developments, and prospects. It introduces the fundamentals of CE and clearly outlines the procedures used to mitigate several barriers, such as detection limits, signal detection, changing capillary environment, resolution separation of analytes, and hyphenation of mass spectrometry with CE, for a range of analytical problems. Each chapter outlines a specific electrophoretic variant with detailed instructions and some standard operating procedures. In this respect, the book meets its desired goal of rendering assistance to lovers of electrophoresis.
Analysis And Detection By Capillary Electrophoresis
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Author : Maria Luisa Marina
language : en
Publisher: Elsevier
Release Date : 2005-09-06
Analysis And Detection By Capillary Electrophoresis written by Maria Luisa Marina and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-06 with Science categories.
Capillary Electrophoresis (CE) is a powerful analytical technique used to separate compounds and is increasingly being used in routine analytical laboratories. Analysis and Detection by Capillary Electrophoresis presents developments enabling the enhancement of the detection sensitivity in CE, including the different strategies used to achieve sensitivity requirements. It describes techniques allowing sample preconcentration and sensitive continuous detection systems and looks at recent developments such as chiral analysis in CE and electrochemical detection in microchips. UV-Vis absorbance detection, as the most widely used detection system in CE, is also presented. Analysis and Detection by Capillary Electrophoresis delves into the practical approaches used in the field and will greatly benefit analytical chemists, as well as students, teachers, technical analysts, scientists and researchers involved in capillary electrophoresis. * An overview of practical approaches employed in capillary electrophoresis, including the fundamentals, instrumentation, and applications of continuous detections systems employed in capillary electrophoresis * Covers aspects of capillary electrophoresis that have never previously been covered * Written by leading experts in the field
Capillary Electrophoresis In Biotechnology And Environmental Analysis
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Author : Hasan Parvez
language : en
Publisher: CRC Press
Release Date : 2023-01-06
Capillary Electrophoresis In Biotechnology And Environmental Analysis written by Hasan Parvez and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-06 with Science categories.
This text aims to evaluate the actual impact of high-performance capillary electrophoresis on analytical biotechnology and environmental analysis. The first part of the book presents a survey of present innovations in instrument design and different methods of pre-concentration techniques in order to obtain increased separations at higher sensitivities. The second part contains articles on applications of HPCE to protein and peptide analysis. In the third part, applications of HPCE in the investigation of drug abuse and drug interactions are presented. The last two parts of the book deal with the use of HPCE at low-UV wavelengths and negative-UV absorption. The book should be of interest to those working in HPCE research and applications.
Capillary Electrophoresis In The Early Twenty First Century
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Author : Dr. Oscar Núñez
language : en
Publisher:
Release Date : 2019
Capillary Electrophoresis In The Early Twenty First Century written by Dr. Oscar Núñez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Capillary electrophoresis categories.
Capillary electrophoresis (CE) comprises a family of related separation techniques in which an electric field is used to achieve the separation of components in a mixture. One of the key features of CE is the simplicity of the instrumentation required, and today, these techniques have become powerful analytical tools for high efficiency separation, and the identification of a variety of ionic and neutral compounds. Moreover, the versatility of CE operational modes (capillary zone electrophoresis, micellar electrokinetic capillary chromatography, capillary electrochromatography, capillary isoelectric focusing, isotachophoresis, non-aqueous capillary electrophoresis, etc.) and detection systems (ultraviolet, fluorescence, amperometric, mass spectrometry...) make CE useful for applications in many fields such as environmental, food, pharmaceutical, and forensic analysis. The typcial drawback of CE techniques, based on their low sensitivity when dealing with conventional UV-detection, due to their short detection pathways and the short sample volume introduced into the capillary, has been largely resolved not only by using more sensitive detectors like fluorescence, amperometric, or mass spectrometry, but by the employment of both off-line and on-line enrichment procedures. The aim of this present book is to address the state-of-the art of capillary electrophoresis techniques within this early twenty-first century, by reviewing new trends and the most relevant applications described in the literature. Uses in fields such as food, environmental, forensic and biological analysis are addressed by means of relevant application. The scope of this book is intentionally broad and is aimed at worldwide analytical laboratories, both public and private, at acadamic institutions, as well as researchers.
Nanochromatography And Nanocapillary Electrophoresis
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Author : Imran Ali
language : en
Publisher: John Wiley & Sons
Release Date : 2009-04-01
Nanochromatography And Nanocapillary Electrophoresis written by Imran Ali and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-01 with Science categories.
Detection of drugs at low concentration is required in a variety of biological and medical situations, in order to avoid harmful side effects posed by some drug residues. The book details the instrumentation, detection, and application of nano chromatography (that is, any chromatographic and capillary electrophoretic method dealing with the detection of a sample at nano gram per liter or lower) and capillary electrophoresis in the analyses of biological and environmental samples. Methods discussed include: Nano Gas Chromatography, Nano Capillary Electrophoresis, Nano Chiral Chromatography, Micellar Electrokinetic Chromatography, Supercritical Fluid Chromatography, and Nano High Performance Liquid Chromatography.
Pharmaceutical And Biomedical Applications Of Capillary Electrophoresis
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Author : S.M. Lunte
language : en
Publisher: Elsevier
Release Date : 1996-08-13
Pharmaceutical And Biomedical Applications Of Capillary Electrophoresis written by S.M. Lunte and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-08-13 with Science categories.
The book describes the theory and applications of Capillary Electrophoresis (CE) in the field of pharmaceutical and biomedical analysis. It is targeted towards users who are intimately involved in analytical problems, especially those which involve small samples. This book presents the technique of capillary electrophoresis from the point of view of the serious hands-on use in the field of pharmaceutical and biomedical analysis. An overview of general theory is presented to acquaint the novice with the fundamental principles. A more theoretical approach is taken in the presentation of electrokinetic chromatography. The next chapter discusses advances in column technologies, the preceding chapters having provided a foundation as to how separations occur. In the next three chapters, recognized experts in their fields present fundamentals and state-of-the-art techniques in the areas of optical, electrochemical and mass spectrometric detection. The major focus of the remaining chapters is on applications. This includes the analysis of pharmaceuticals, amino acids and peptides, macromolecules, nucleosides, nucleotides and oligonucleotides. The use of CE for analysis of small ions and separation of biological particles is also discussed. The issue of sample preparation for analysis by CE is addressed, especially as it relates to clinical analysis.