Cracking The Genome
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Cracking The Genome
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Author : Kevin Davies
language : en
Publisher: Simon and Schuster
Release Date : 2001-01-05
Cracking The Genome written by Kevin Davies and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-05 with Science categories.
In 1953, James Watson and Francis Crick discovered the double helix structure of DNA. The discovery was a profound, Nobel Prize-winning moment in the history of genetics, but it did not decipher the messages on the twisted, ladderlike strands within our cells. No one knew what the human genome sequence actually was. No one had cracked the code of life. Now, at the beginning of a new millennium, that code has been cracked. Kevin Davies, founding editor of the leading journal in the field, Nature Genetics, has relentlessly followed the story as it unfolded, week by week, for ten years. Here for the first time, in rich human, scientific, and financial detail, is the dramatic story of one of the greatest scientific feats ever accomplished: the mapping of the human genome. In 1990, the U.S. government approved a 15-year, $3 billion plan to launch the Human Genome Project, whose goal was to sequence the 3 billion letters of human DNA. At the helm of the project was James Watson, who resigned after only a couple of years, following a feud with National Institutes of Health (NIH) Director Bernadine Healy over gene patenting. His successor was the brilliant young medical geneticist Francis Collins, who had made his name discovering the gene for cystic fibrosis. As Davies reports, Collins is a devout Christian who has traveled to Africa to work in a missionary hospital. He believes the human genome sequence is "the language of God." Just as Collins became project director, J. Craig Venter, a maverick DNA sequencer and Vietnam veteran, was leaving the NIH to start his own private research institute. Venter had developed a simple "shotgun" strategy for sequencing DNA, and his fame skyrocketed when his new institute proved his sequencing system worked by becoming the first to sequence the entire genome of a microorganism. Only 3 percent of the human genome had been sequenced by early 1998, the public project's halfway point. That same year, Venter was approached by PE Corporation to launch a private human genome project. He stunned the world when he announced the formation of a new company to sequence the human genome in a mere three years for $300 million. A war of words broke out between public and private researchers. Undeterred, Venter built Celera Genomics with the motto "Speed matters. Discovery can't wait." and an $80 million supercomputer. While the insults intensified, Celera's stock price soared, tumbled, and soared again. Negotiations for cooperation between the public and private institutes began, only to fall apart in acrimony. Then in the spring of 2000 President Clinton stepped in, telling his science adviser to restart negotiations. History was about to be made. Davies captures the drama of this momentous achievement, drawing on his own genetics expertise and interviews with key scientists including Venter and Collins, as well as Eric Lander, an MIT computer wizard who refers to the public genome project as "the forces of good"; Kari Stefánsson, the genetics entrepreneur who is remaking Iceland's economy; and John Sulston, chief of the UK genome project, who led the charge against gene patenting. Davies has visited geneticists around the world to illustrate a vast international enterprise working on the frontier of human knowledge. Cracking the Genome is the definitive account of how the code that holds the answers to the origin of life, the evolution of humanity, and the future of medicine was broken.
The Human Genome Project
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Author : Thomas F. Lee
language : en
Publisher: Springer
Release Date : 1991-01-01
The Human Genome Project written by Thomas F. Lee and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-01-01 with Medical categories.
Describes the ten-year, multimillion dollar Human Genome Project and its process of gene mapping; includes concerns of critics of the project.
Life S Greatest Secret
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Author : Matthew Cobb
language : en
Publisher: Profile Books
Release Date : 2015-06-11
Life S Greatest Secret written by Matthew Cobb and has been published by Profile Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-11 with History categories.
Life's Greatest Secret is the story of the discovery and cracking of the genetic code. This great scientific breakthrough has had far-reaching consequences for how we understand ourselves and our place in the natural world. The code forms the most striking proof of Darwin's hypothesis that all organisms are related, holds tremendous promise for improving human well-being, and has transformed the way we think about life. Matthew Cobb interweaves science, biography and anecdote in a book that mixes remarkable insights, theoretical dead-ends and ingenious experiments with the pace of a thriller. He describes cooperation and competition among some of the twentieth century's most outstanding and eccentric minds, moves between biology, physics and chemistry, and shows the part played by computing and cybernetics. The story spans the globe, from Cambridge MA to Cambridge UK, New York to Paris, London to Moscow. It is both thrilling science and a fascinating story about how science is done.
A Crack In Creation
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Author : Jennifer Doudna
language : en
Publisher: Random House
Release Date : 2017-06-15
A Crack In Creation written by Jennifer Doudna and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-15 with Science categories.
'The most important advance of our era. One of the pioneers of the field describes the exciting hunt for the key breakthrough and what it portends for our future' Walter Isaacson World-famous scientist Jennifer Doudna - winner of the 2020 Nobel Prize in Chemistry for creating the revolutionary gene-editing technique CRISPR - explains her discovery, describes its power to reshape the future of all life and warns of its use. A handful of discoveries have changed the course of human history. This book is about the most recent and potentially the most powerful and dangerous of them all. It is an invention that allows us to rewrite the genetic code that shapes and controls all living beings. As a result, dreams of genetic manipulation have become a stark reality: the power to cure disease and alleviate suffering, as well as to re-design any species, including humans, for our own ends. Jennifer Doudna is the co-inventor of this technology - known as CRISPR - and a scientist of worldwide renown. Writing with fellow researcher Samuel Sternberg, here she provides the definitive account of her discovery, explaining how this wondrous invention works and what it is capable of. She also asks us to consider what our new-found power means: how do we enjoy its unprecedented benefits while avoiding its equally unprecedented dangers? _________________ PRAISE FOR A CRACK IN CREATION: 'The future is in our hands as never before, and this book explains the stakes like no other' George Lucas 'One of the most PIONEERING women in science . . . Exhilarating' Arianna Huffington 'Thrilling' Adam Rutherford 'An instant classic' Siddhartha Mukherjee
The Genome Odyssey
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Author : Dr. Euan Angus Ashley
language : en
Publisher: Celadon Books
Release Date : 2021-02-23
The Genome Odyssey written by Dr. Euan Angus Ashley and has been published by Celadon Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-23 with Science categories.
In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease. Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human. In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome. These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.
Genomes 3
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Author : Terence A. Brown
language : en
Publisher: Garland Science
Release Date : 2007
Genomes 3 written by Terence A. Brown and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Science categories.
The VitalBook e-book version of Genomes 3 is only available in the US and Canada at the present time. To purchase or rent please visit http://store.vitalsource.com/show/9780815341383 Covering molecular genetics from the basics through to genome expression and molecular phylogenetics, Genomes 3is the latest edition of this pioneering textbook. Updated to incorporate the recent major advances, Genomes 3 is an invaluable companion for any undergraduate throughout their studies in molecular genetics. Genomes 3 builds on the achievements of the previous two editions by putting genomes, rather than genes, at the centre of molecular genetics teaching. Recognizing that molecular biology research was being driven more by genome sequencing and functional analysis than by research into genes, this approach has gathered momentum in recent years.
A Life Decoded
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Author : J. Craig Venter
language : en
Publisher: Penguin
Release Date : 2007-10-18
A Life Decoded written by J. Craig Venter and has been published by Penguin this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-18 with Biography & Autobiography categories.
The triumphant memoir of the man behind one of the greatest feats in scientific history Of all the scientific achievements of the past century, perhaps none can match the deciphering of the human genetic code, both for its technical brilliance and for its implications for our future. In A Life Decoded, J. Craig Venter traces his rise from an uninspired student to one of the most fascinating and controversial figures in science today. Here, Venter relates the unparalleled drama of the quest to decode the human genome?a goal he predicted he could achieve years earlier and more cheaply than the government-sponsored Human Genome Project, and one that he fulfilled in 2001. A thrilling story of detection, A Life Decoded is also a revealing, and often troubling, look at how science is practiced today.
Editing Humanity
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Author : Kevin Davies
language : en
Publisher: Simon and Schuster
Release Date : 2020-10-06
Editing Humanity written by Kevin Davies and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-06 with Science categories.
One of the world's leading experts on genetics unravels one of the most important breakthroughs in modern science and medicine. IIf our genes are, to a great extent, our destiny, then what would happen if mankind could engineer and alter the very essence of our DNA coding? Millions might be spared the devastating effects of hereditary disease or the challenges of disability, whether it was the pain of sickle-cell anemia to the ravages of Huntington’s disease. But this power to “play God” also raises major ethical questions and poses threats for potential misuse. For decades, these questions have lived exclusively in the realm of science fiction, but as Kevin Davies powerfully reveals in his new book, this is all about to change. Engrossing and page-turning, Editing Humanity takes readers inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces readers to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale. Though the birth of the “CRISPR babies” in China made international news, there is much more to the story of CRISPR than headlines seemingly ripped from science fiction. In Editing Humanity, Davies sheds light on the implications that this new technology can have on our everyday lives and in the lives of generations to come.
Politics In The Laboratory
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Author : Ira H. Carmen
language : en
Publisher: Univ of Wisconsin Press
Release Date : 2004
Politics In The Laboratory written by Ira H. Carmen and has been published by Univ of Wisconsin Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
Ira Carmen seeks a fusion of experimental biological research and political science research as he explores the important and controversial realm of human genomics. Politics in the Laboratory takes a close look at the ethical, legal, social, constitutional, and political implications of modern biological research. It addresses both biopolicy issues and basic science--including cloning, embryonic stem cell investigations, and experimentation involving the human germline--from the perspective of a political scientist.
A Prescription For Change
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Author : Michael Kinch
language : en
Publisher: UNC Press Books
Release Date : 2016-10-07
A Prescription For Change written by Michael Kinch and has been published by UNC Press Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-07 with Medical categories.
The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes — and indeed because of them — our ability to deliver new medicines may be quickly coming to an end. Moving from the beginning of the twentieth century to the present, A Prescription for Change reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy. To explain how we have arrived at this pivotal moment, Michael Kinch recounts the history of pharmaceutical and biotechnological advances in the twentieth century. Kinch relates stories of the individuals and organizations that built the modern infrastructure that supports the development of innovative new medicines. He shows that an accelerating cycle of acquisition and downsizing is cannibalizing that infrastructure Kinch demonstrates the dismantling of the pharmaceutical and biotechnological research and development enterprises could also provide opportunities to innovate new models that sustain and expand the introduction of newer and better breakthrough medicines in the years to come.