Cryptorchidism
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Cryptorchidism
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Author : F. Hadziselimovic
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cryptorchidism written by F. Hadziselimovic and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Ferment, a sign of progress in any scientific field, has previously been lacking in the area of cryptorchidism, where the only activity has been in improving operative methods. Now, however, profound changes in the care of boys with cryptorchidism are being brought about; ideas are arising from a fresh look at comparative anatomy, and histological and experimental observa tions are being supplemented by clinical tests made possible by new hormonal agents. The treatment of cryptorchidism begins with its recognition by the pediatri cian, who until now has shown little interest because of disappointing results from chorionic gonadotropin administration. As for the surgeon, his bent toward restoration of normal anatomical relationships has kept his attention focused on the development of better surgical technics to bring the recalci trant testis into the scrotum. Both specialists have avoided the primordial question of why the testis did not descend properly. If this were known they would treat the cause of cryptorchidism, and not be satisfied merely with trying to correct its end result. As one reads this book, one sees that in most patients cryptorchidism is not caused by some anatomical structure blocking the way or by some deformity of the testis interfering with the transport mechanism. Rather, deficiencies in the hormonal environment of the fetus retard the developmen tal sequences essential to the normal differentiation and descent of the testis. The clinical solution is thus to provide the deficient substances.
Normal Testicular Descent And The Aetiology Of Cryptorchidism
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Author : John M. Hutson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Normal Testicular Descent And The Aetiology Of Cryptorchidism written by John M. Hutson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This review describes recent research into the cause of testicular descent and discusses two controversial theories on the mechanism. New animal models of cryptorchidism are described which shed light on the possible aetiology. A brief summary is given of current management, highlighting the controversies of timing of surgery, use of hormone therapy and congenital versus 'acquired' undescended testes. New information about germ cell development in the postnatal testis is changing the way we view treatment and the ultimate prognosis.
Cryptorchidism
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Author : Jürgen R. Bierich
language : en
Publisher:
Release Date : 1979
Cryptorchidism written by Jürgen R. Bierich and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Medical categories.
Cryptorchidism
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Author : F. Hadziselimovic
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cryptorchidism written by F. Hadziselimovic and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cytological techniques have greatly improved in the last twenty years, largely as a result of further development of the microscope. Electron microscopy, in particular, has opened up great prospects for the study of cell morphology, while the develop ment of radio-immuno-assay has brought great progress in endocrinology. The applica tion of these two techniques, which are complementary to each other and provide mutually supporting evidence, is the subject of this monograph. The work is divided into two parts. The first deals with the ultrastructure of normal testicular development, describing four main elements of the testicle - the germ cells, the Sertoli cells, the peri tubular connective tissue and the Leydig cell- with details of their individual development. To make the electron micrographs more easily understandable, diagrams have been used to explain the most important points. The second part deals with cryptorchid testicles, including the primary and sec ondary changes involved and morphometric studies of the secondary changes. The significance of these ultrastructural observations for the treatment of cryptorchidism is emphasized. With the aid of radio-immuno-assay the level of testosterone in cryp torchid mice was determined and comparisons drawn between the ultrastructural changes in cryptorchidism in mouse and man. The experimental studies served as a basis for the hypothesis that, in all probability, a congenital disturbance of the hy pothalamo-hypophyso-gonadal axis is responsible for cryptorchidism. I hope that this monograph will contribute towards a better understanding of normal and cryptorchid testicular development and of the etiology of cryptorchidism.
The Cryptorchid Testis
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Author : Thomas O. Abney
language : en
Publisher: CRC Press
Release Date : 2020-08-11
The Cryptorchid Testis written by Thomas O. Abney and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-11 with Medical categories.
Current knowledge concerning both morphological and functional cryptorchid-related alterations in the various testicular compartments is summarized in this valuable new publication. Damage to the germinal epithelium and resulting infertility in both humans and experimental animals as well as the degree of damage to the different stages of germ cell development is discussed. In addition, information concerning hormonal therapy and orchidopexy to reverse cryptorchid-related damage is provided. Morphological alterations in Sertoli and Leydig cells is discussed in terms of cellular hypertrophy and hyperplasia, alterations in organelle number and characteristics as well as changes in cell-cell junctional complexes. Changes in Sertoli cell and Leydig cell function, including gonadotropin binding, steroidogenesis and other metabolic alterations is also outlined,as well as the influence of altered testicular function on subsequent hypothalamic-pituitary changes. Vascular disruption, the potential role of paracrine substances and direct thermal damage, all of which may be responsible for the resulting detrimental changes in one or more testicular compartments, are considered.
Cryptorchidism
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Author : Faruk Hadziselimovic
language : en
Publisher: Springer
Release Date : 1977-01-01
Cryptorchidism written by Faruk Hadziselimovic and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977-01-01 with Cryptorchism categories.
Cryptorchidism Causes And Consequences
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Author : Richard Ivell
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-24
Cryptorchidism Causes And Consequences written by Richard Ivell and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-24 with categories.
Cryptorchidism is the failure of one or both testes to descend into the scrotum at birth or shortly thereafter, depending on species, or the ascent of previously descended testes later in life. It is the commonest of all congenital conditions in the human representing between 1 and 9% of all male babies born. It is also common in domestic species such as pigs, dogs and horses. Importantly, cryptorchidism is seen as a sentinel of fetal well-being and is associated with other less common ailments such as testis cancer and hypospadias as part of the testicular dysgenesis syndrome (TDS), as well as being linked to maternal smoking and intrauterine growth restriction. It also likely results from maternal exposure to endocrine disrupting chemicals. Surprisingly, we know relatively little about its immediate causes although deficits in fetal hormonal signaling through INSL3 or testosterone and complex genetic susceptibility seem to be involved. The testes may be affected unilaterally or bilaterally with anatomical arrest anywhere between the abdomen to just above the scrotum. Significantly, we need to distinguish between the consequences of cryptorchidism simply due to retention of the testes within the body cavity at abdominal rather than scrotal temperature, and those sequelae which share a common fetal cause. The former are largely correctable by early orchidopexy. In this Research Topic we aim to bring together a broad selection of articles (reviews, original research articles, commentaries and hypotheses) from the leading experts in the field, discussing all aspects of this common congenital condition, and throwing light on its genetic and environmental causes including its relationship to TDS and the biological mechanisms involved, its sequelae, and how these relate to optimal treatment.
Descended And Cryptorchid Testis
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Author : E.S. Hafez
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Descended And Cryptorchid Testis written by E.S. Hafez and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
During the past decade extensive investigations have been done on the testis. Since the observations have been published in many different journals. it seemed appropriate to bring together and summarize some of the pertinent findings in a single volume. Twenty-eight scientists and clinicians from nine countries have contributed to this book. They have reviewed the literature and presented their own, new observations on the developmentaL anatomicaL physiologicaL biochemical and pathological aspects of the descended and cryptorchid testis. In addition, several contributors have evaluated the usefulness of certain animals as models for systematically studying specific aspects of cryptorchidism. It is hoped that this volume will serve as a useful summary and reference for those working in this area and that it will encourage further research in testicular physiopathology. The editor thanks the contributors for their enthusiasm, cooperation and meticulous writing of the chapters. The support of the Departments of GynecologyjObstetrics and the Department of Physiology of Wayne State University School of Medicine. Detroit and the assistance from the staff of Martinus Nijhoff are gratefully acknowledged. The cheerful cooperation of Miss Lori Rust and Miss Penny Stoops who helped to type and assemble the volume is most deeply appreciated.
Cryptorchidism
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Author : F Hadziselimovic
language : en
Publisher:
Release Date : 1982-12-01
Cryptorchidism written by F Hadziselimovic and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-12-01 with categories.
The Undescended Testis
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Author : Eric W. Fonkalsrud
language : en
Publisher: Year Book Medical Publishers, Incorporated
Release Date : 1981
The Undescended Testis written by Eric W. Fonkalsrud and has been published by Year Book Medical Publishers, Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Medical categories.