Crystallographic Studies Of Pore Forming Protein Toxins
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Crystallographic Studies Of Pore Forming Protein Toxins
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Author : Susanne C. Feil
language : en
Publisher:
Release Date : 2002
Crystallographic Studies Of Pore Forming Protein Toxins written by Susanne C. Feil and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Crystallography categories.
Pore Forming Toxins
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-03-10
Pore Forming Toxins written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-10 with Science categories.
Pore Forming Toxins, Volume 649 in the Methods in Enzymology series continues the legacy of this premier serial with quality chapters authored by field leaders. Chapters in this new release include X-ray crystallography shines a light on pore-forming toxins, Giant unilamellar vesicles for studying activity of pore forming proteins, Combined applications of fluorescence spectroscopy and molecular dynamics simulations in studies of Diphtheria Toxin translocation domain, Biophysical approaches to study actinoporin-lipid interactions, Molecular basis for activation of Actinoporins by lipids, Engineered ClyA for detection of biological molecules, Pore-forming Toxins for the Size-Discrimination of Polymers and Biopolymers: Towards Biomolecules Sequencing, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series
Pore Forming Toxins
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Author : Gisou van der Goot
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pore Forming Toxins written by Gisou van der Goot and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Pore-forming toxins are virulence factors produced by a great variety of pathogenic bacteria ranging from the Gram-positive Staphylococcus aureus to the Gram-negative Helicobacter pylory. The recent studies reviewed in this volume describe the progress that has been made in dissecting the different steps of the mode of action of these proteins which generally include binding to specific cell surface receptors, oligomerization into ring like structures and membrane perforation.
Pore Forming Toxins
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Author : Gisou van der Goot
language : en
Publisher:
Release Date : 2014-09-01
Pore Forming Toxins written by Gisou van der Goot and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-01 with categories.
Protein Toxin Structure
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Author : Michael W. Parker
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Protein Toxin Structure written by Michael W. Parker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Joseph E. Alouf "The empirical basis of objective science has thus nothing 'abso lute' about it. Science does not rest upon solid bedrock. The bold structure of its theories rises, as it were, above swamp. It is like a building erected on piles. The piles are driven down from above into the swamp, but not down to any natural or 'given' base; and if we stop driving the piles deeper, it is not because we have reached firm ground. We simply stop when we are satisfied that the piles are firm enough to carry the structure, at least for the time being. " -Karl Popper (The Logic of Scientific Discovery) hen I was invited to write this introductory chapter I was hon W ored and pleased to have the opportunity to briefly highlight some important issues relevant to structural aspects of bacterial protein tox ins. The present book attempts for the first time to provide into one volume a series of chapters prepared by invited experts on the struc ture of these fascinating macromolecules. A particular emphasis is placed on the molecular features of these highly active biomolecules in rela tion to their biological properties and mechanisms of action. The researchers in bacterial protein toxinology of my generation have had the privilege of witnessing over 40 years the tremen dous development of this field of biological sciences, particularly in the past decade.
Pore Forming Peptides And Protein Toxins
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Author : Gianfranco Menestrina
language : en
Publisher: CRC Press
Release Date : 2003-01-30
Pore Forming Peptides And Protein Toxins written by Gianfranco Menestrina and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-30 with Medical categories.
Pore-forming proteins and peptides play a central role in bacterial pathogenesis, the immune response, defense from venomous attack, and innate immunity. These proteins attack and eliminate other organisms by punching an aqueous channel through their membranes, which disrupts appropriate cell function. The discovery of this cellular interaction has
Structural And Biochemical Characterization Of The Yaxab Pore Forming Toxin From Yersinia Enterocolitica
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Author : Bastian Bräuning
language : en
Publisher: Springer Nature
Release Date : 2019-09-26
Structural And Biochemical Characterization Of The Yaxab Pore Forming Toxin From Yersinia Enterocolitica written by Bastian Bräuning and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-26 with Science categories.
This book discusses the decoding of the lytic mechanism of an α-helical pore-forming toxin, YaxAB, composed of two different subunits. Pore-forming toxins (PFTs) are among the most common bacterial toxins. They are produced by a variety of pathogens, which infect a wide range of organisms including plants, insects and humans. Yet the maturation of these particles and the structural changes required for pore formation are still poorly understood for many PFT families. Using a diverse panel of biochemical and structural techniques, including X-ray crystallography and cryo-electron microscopy, Dr. Bräuning and colleagues have succeeded in identifying the mechanistic contributions of the two toxin components and elucidating the lytic state of the pore complex. The results of this thesis on the YaxAB system are applicable to orthologues from agriculturally relevant insect pathogens, and offer valuable structural and mechanistic insights to inform future bioengineering efforts.
Crystal Structure Of The Pore Forming Toxin Cytolysin A In Its Assembled Form
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Author : Marcus Müller
language : en
Publisher:
Release Date : 2009
Crystal Structure Of The Pore Forming Toxin Cytolysin A In Its Assembled Form written by Marcus Müller and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Bacterial Protein Toxins
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Author : K. Aktories
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Bacterial Protein Toxins written by K. Aktories and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Medical categories.
In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.
The Comprehensive Sourcebook Of Bacterial Protein Toxins
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Author : Joseph E. Alouf
language : en
Publisher: Elsevier
Release Date : 2005-12-20
The Comprehensive Sourcebook Of Bacterial Protein Toxins written by Joseph E. Alouf and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-20 with Science categories.
This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology Includes the major toxins of both basic and clinical interest are described in depth Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology Evolutionary and functional aspects of bacterial toxins evaluated and summarized Toxin applications in cell biology presented Therapy (cancer therapy, dystonias) discussed Vaccines (native and genetically engineered vaccines) featured Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.