Pore Forming Peptides And Protein Toxins

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Pore Forming Peptides And Protein Toxins

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Author : Gianfranco Menestrina
language : en
Publisher: CRC Press
Release Date : 2003-01-30

Pore Forming Peptides And Protein Toxins written by Gianfranco Menestrina and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-30 with Medical categories.

Pore-forming proteins and peptides play a central role in bacterial pathogenesis, the immune response, defense from venomous attack, and innate immunity. These proteins attack and eliminate other organisms by punching an aqueous channel through their membranes, which disrupts appropriate cell function. The discovery of this cellular interaction has

Proteins

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Author : Gregor Anderluh
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-11

Proteins written by Gregor Anderluh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-11 with Medical categories.

Formation of transmembrane pores is a very effective way of killing cells. It is thus not surprising that many bacterial and eukaryotic toxic agents are pore-forming proteins. Pore formation in a target membrane is a complex process composed of several steps; proteins need to attach to the lipid membrane, possibly aggregate in the plane of the membrane and finally form a pore by inserting part of the polypeptide chain across the lipid bilayer. Structural information about toxins at each stage is indispensible for the biochemical and molecular biological studies that aim to - derstand how pores are formed at the molecular level. There are currently only two Staphylococcus aureus and hemolysin E from Escherichia coli. Therefore, what we know about these proteins was obtained over many years of intense experimentation. We have nevertheless, in the last couple of years, witnessed a significant rise in structural information on the soluble forms of pore-forming proteins. Surprisingly, many unexpected similarities with other proteins were noted, despite extremely low or insignificant sequence similarity. It appears that lipid membrane binding and formation of transmembrane channels is achieved in many cases by a limited repertoire of structures. This book describes how several of the important pore forming toxin families achieve membrane bi- ing and which structural elements are used for formation of transmembrane pores. Our contributors have thus provided the means for a comparative analysis of several unrelated families.

Pore Forming Toxins

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Author : Gisou van der Goot
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Pore Forming Toxins written by Gisou van der Goot and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

Pore-forming toxins are virulence factors produced by a great variety of pathogenic bacteria ranging from the Gram-positive Staphylococcus aureus to the Gram-negative Helicobacter pylory. The recent studies reviewed in this volume describe the progress that has been made in dissecting the different steps of the mode of action of these proteins which generally include binding to specific cell surface receptors, oligomerization into ring like structures and membrane perforation.

The Comprehensive Sourcebook Of Bacterial Protein Toxins

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Author : Joseph E. Alouf
language : en
Publisher: Elsevier
Release Date : 2005-12-20

The Comprehensive Sourcebook Of Bacterial Protein Toxins written by Joseph E. Alouf and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-20 with Science categories.

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology Includes the major toxins of both basic and clinical interest are described in depth Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology Evolutionary and functional aspects of bacterial toxins evaluated and summarized Toxin applications in cell biology presented Therapy (cancer therapy, dystonias) discussed Vaccines (native and genetically engineered vaccines) featured Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

Crystallographic Studies Of Pore Forming Protein Toxins

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Author : Susanne C. Feil
language : en
Publisher:
Release Date : 2002

Crystallographic Studies Of Pore Forming Protein Toxins written by Susanne C. Feil and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Crystallography categories.

From Peptide And Protein Toxins To Ion Channel Structure Function And Drug Design

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Author : Victor I. Tsetlin
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-09

From Peptide And Protein Toxins To Ion Channel Structure Function And Drug Design written by Victor I. Tsetlin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-09 with Science categories.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Bacterial Protein Toxins

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Author : Drusilla L. Burns
language : en
Publisher:
Release Date : 2003

Bacterial Protein Toxins written by Drusilla L. Burns and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.

Table of contents http://www.loc.gov/catdir/toc/fy037/2002152890.html.

Comprehensive Biophysics

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Author :
language : en
Publisher: Academic Press
Release Date : 2012-04-12

Comprehensive Biophysics written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-12 with Science categories.

Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource

Pore Forming Cytotoxic Proteins Advances In Research And Application 2012 Edition

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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26

Pore Forming Cytotoxic Proteins Advances In Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Science categories.

Pore Forming Cytotoxic Proteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pore Forming Cytotoxic Proteins. The editors have built Pore Forming Cytotoxic Proteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pore Forming Cytotoxic Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Pore Forming Cytotoxic Proteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Bacterial Toxins

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Author : Klaus Aktories
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-26

Bacterial Toxins written by Klaus Aktories and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-26 with Science categories.

This is a survey of well characterized and recently discovered bacterial protein toxins. Leading investigators of the respective toxins review the various molecular mechanisms of action, ranging from toxin-induced ADP-ribosylation up to membrane perforation by pore-forming toxins. Thy also describe the consequences on host physiology before focusing on potential applications as cell biological and pharmacological tools for research and medical applications. Detailed descriptions of the methodology include the engineering and use of modified and chimeric toxins for better performance. A solid introduction to toxin structure and functions, as well as a valuable source of methodology for researchers in molecular biology, pharmacology and experimental medicine.