From Peptide And Protein Toxins To Ion Channel Structure Function And Drug Design
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From Peptide And Protein Toxins To Ion Channel Structure Function And Drug Design
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Author : Victor I. Tsetlin
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-09
From Peptide And Protein Toxins To Ion Channel Structure Function And Drug Design written by Victor I. Tsetlin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-09 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Ion Channel Drug Discovery
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Author : Brian Cox
language : en
Publisher: Royal Society of Chemistry
Release Date : 2014-09-24
Ion Channel Drug Discovery written by Brian Cox and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-24 with Medical categories.
A rapidly growing field, this book covers the recent advances in screening technology, ion channel structure and modelling, with up-to-date case histories.
Ion Channel Structure And Drug Discovery Accelerated By Cryo Em
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Author : Shujia Zhu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-30
Ion Channel Structure And Drug Discovery Accelerated By Cryo Em written by Shujia Zhu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Science categories.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Voltage Gated Sodium Channels
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Author : Peter C. Ruben
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-04-15
Voltage Gated Sodium Channels written by Peter C. Ruben and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-15 with Medical categories.
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Venoms To Drugs
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Author : Glenn King
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-02-11
Venoms To Drugs written by Glenn King and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-11 with Science categories.
This unique book will provide an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book will provide the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.
Structure Function Relationship Of K Ion Channel Toxins
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Author : Isabelle Huys
language : en
Publisher: Leuven University Press
Release Date : 2004
Structure Function Relationship Of K Ion Channel Toxins written by Isabelle Huys and has been published by Leuven University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Science categories.
"This is a Ph.D. dissertation. Many fundamental processes underlying nerve and muscle excitation, hormone secretion, learning and memory, cell proliferation, sensory transduction and regulation of blood pressure and osmotic balance, are attributed to a div"
Isotope Labeling In Biomolecular Nmr
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Author : Hanudatta S. Atreya
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-18
Isotope Labeling In Biomolecular Nmr written by Hanudatta S. Atreya and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-18 with Medical categories.
NMR spectroscopy has undergone a revolution in recent years with the advent of several new methods overcoming the problems of sensitivity and resolution. Recent developments in biotechnology have made it easier and economical to introduce 13C, 15N and 2H into proteins and nucleic acids. At the same time, there has been an explosion in the number of NMR experiments that utilize such isotope labeled samples. Thus, a combination of isotopic labeling and multidimensional, multinuclear NMR has opened up new avenues for structural studies of proteins, nucleic acids and their complexes. This book will focus on recent developments in isotope labeling methods for structural studies of small molecules, peptides, proteins and nucleic acids. The aim of the book is to serve as a compendium of isotope labeling for the biomolecular NMR community providing comprehensive coverage of the existing methods and latest developments along with protocols and practical hints on the various experimental aspects. The book will cover a wide range of topics in isotope labeling under one title including emerging areas of metabolonomics and solid state NMR.
Ion Channels And Disease
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Author : Frances M. Ashcroft
language : en
Publisher: Academic Press
Release Date : 1999-10-20
Ion Channels And Disease written by Frances M. Ashcroft and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-10-20 with Science categories.
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
Textbook Of Drug Design And Discovery
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Author : H. John Smith
language : en
Publisher: CRC Press
Release Date : 2002-08-01
Textbook Of Drug Design And Discovery written by H. John Smith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-08-01 with Medical categories.
Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lea