Cure Models

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Cure Models

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Author : Yingwei Peng
language : en
Publisher: CRC Press
Release Date : 2021-03-22

Cure Models written by Yingwei Peng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-22 with Mathematics categories.

Cure Models: Methods, Applications and Implementation is the first book in the last 25 years that provides a comprehensive and systematic introduction to the basics of modern cure models, including estimation, inference, and software. This book is useful for statistical researchers and graduate students, and practitioners in other disciplines to have a thorough review of modern cure model methodology and to seek appropriate cure models in applications. The prerequisites of this book include some basic knowledge of statistical modeling, survival models, and R and SAS for data analysis. The book features real-world examples from clinical trials and population-based studies and a detailed introduction to R packages, SAS macros, and WinBUGS programs to fit some cure models. The main topics covered include the foundation of statistical estimation and inference of cure models for independent and right-censored survival data, cure modeling for multivariate, recurrent-event, and competing-risks survival data, and joint modeling with longitudinal data, statistical testing for the existence and difference of cure rates and sufficient follow-up, new developments in Bayesian cure models, applications of cure models in public health research and clinical trials.

Advanced Survival Models

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Author : Catherine Legrand
language : en
Publisher: CRC Press
Release Date : 2021-03-22

Advanced Survival Models written by Catherine Legrand and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-22 with Mathematics categories.

Survival data analysis is a very broad field of statistics, encompassing a large variety of methods used in a wide range of applications, and in particular in medical research. During the last twenty years, several extensions of "classical" survival models have been developed to address particular situations often encountered in practice. This book aims to gather in a single reference the most commonly used extensions, such as frailty models (in case of unobserved heterogeneity or clustered data), cure models (when a fraction of the population will not experience the event of interest), competing risk models (in case of different types of event), and joint survival models for a time-to-event endpoint and a longitudinal outcome. Features Presents state-of-the art approaches for different advanced survival models including frailty models, cure models, competing risk models and joint models for a longitudinal and a survival outcome Uses consistent notation throughout the book for the different techniques presented Explains in which situation each of these models should be used, and how they are linked to specific research questions Focuses on the understanding of the models, their implementation, and their interpretation, with an appropriate level of methodological development for masters students and applied statisticians Provides references to existing R packages and SAS procedure or macros, and illustrates the use of the main ones on real datasets This book is primarily aimed at applied statisticians and graduate students of statistics and biostatistics. It can also serve as an introductory reference for methodological researchers interested in the main extensions of classical survival analysis.

Bayesian Survival Analysis

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Author : Joseph G. Ibrahim
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09

Bayesian Survival Analysis written by Joseph G. Ibrahim and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.

Survival analysis arises in many fields of study including medicine, biology, engineering, public health, epidemiology, and economics. This book provides a comprehensive treatment of Bayesian survival analysis. Several topics are addressed, including parametric models, semiparametric models based on prior processes, proportional and non-proportional hazards models, frailty models, cure rate models, model selection and comparison, joint models for longitudinal and survival data, models with time varying covariates, missing covariate data, design and monitoring of clinical trials, accelerated failure time models, models for mulitivariate survival data, and special types of hierarchial survival models. Also various censoring schemes are examined including right and interval censored data. Several additional topics are discussed, including noninformative and informative prior specificiations, computing posterior qualities of interest, Bayesian hypothesis testing, variable selection, model selection with nonnested models, model checking techniques using Bayesian diagnostic methods, and Markov chain Monte Carlo (MCMC) algorithms for sampling from the posteiror and predictive distributions. The book presents a balance between theory and applications, and for each class of models discussed, detailed examples and analyses from case studies are presented whenever possible. The applications are all essentially from the health sciences, including cancer, AIDS, and the environment. The book is intended as a graduate textbook or a reference book for a one semester course at the advanced masters or Ph.D. level. This book would be most suitable for second or third year graduate students in statistics or biostatistics. It would also serve as a useful reference book for applied or theoretical researchers as well as practitioners.

Frailty Models In Survival Analysis

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Author : Andreas Wienke
language : en
Publisher: CRC Press
Release Date : 2010-07-26

Frailty Models In Survival Analysis written by Andreas Wienke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-26 with Mathematics categories.

The concept of frailty offers a convenient way to introduce unobserved heterogeneity and associations into models for survival data. In its simplest form, frailty is an unobserved random proportionality factor that modifies the hazard function of an individual or a group of related individuals. Frailty Models in Survival Analysis presents a comprehensive overview of the fundamental approaches in the area of frailty models. The book extensively explores how univariate frailty models can represent unobserved heterogeneity. It also emphasizes correlated frailty models as extensions of univariate and shared frailty models. The author analyzes similarities and differences between frailty and copula models; discusses problems related to frailty models, such as tests for homogeneity; and describes parametric and semiparametric models using both frequentist and Bayesian approaches. He also shows how to apply the models to real data using the statistical packages of R, SAS, and Stata. The appendix provides the technical mathematical results used throughout. Written in nontechnical terms accessible to nonspecialists, this book explains the basic ideas in frailty modeling and statistical techniques, with a focus on real-world data application and interpretation of the results. By applying several models to the same data, it allows for the comparison of their advantages and limitations under varying model assumptions. The book also employs simulations to analyze the finite sample size performance of the models.

Textbook Of Clinical Trials In Oncology

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Author : Susan Halabi
language : en
Publisher: CRC Press
Release Date : 2019-04-24

Textbook Of Clinical Trials In Oncology written by Susan Halabi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-24 with Medical categories.

There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area. The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology. Key Features: Cutting-edge topics with appropriate technical background Built around case studies which give the work a "hands-on" approach Real examples of flaws in previously reported clinical trials and how to avoid them Access to statistical code on the book’s website Chapters written by internationally recognized statisticians from academia and pharmaceutical companies Carefully edited to ensure consistency in style, level, and approach Topics covered include innovating phase I and II designs, trials in immune-oncology and rare diseases, among many others

Bayesian Mediation Analysis Using R

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Author : Atanu Bhattacharjee
language : en
Publisher: CRC Press
Release Date : 2024-07-04

Bayesian Mediation Analysis Using R written by Atanu Bhattacharjee and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-04 with Mathematics categories.

Delve into the realm of statistical methodology for mediation analysis with a Bayesian perspective in high dimensional data through this comprehensive guide. Focused on various forms of time-to-event data methodologies, this book helps readers master the application of Bayesian mediation analysis using R. Across ten chapters, this book explores concepts of mediation analysis, survival analysis, accelerated failure time modeling, longitudinal data analysis, and competing risk modeling. Each chapter progressively unravels intricate topics, from the foundations of Bayesian approaches to advanced techniques like variable selection, bivariate survival models, and Dirichlet process priors. With practical examples and step-by-step guidance, this book empowers readers to navigate the intricate landscape of high-dimensional data analysis, fostering a deep understanding of its applications and significance in diverse fields.

Frontiers Of Biostatistical Methods And Applications In Clinical Oncology

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Author : Shigeyuki Matsui
language : en
Publisher: Springer
Release Date : 2017-10-03

Frontiers Of Biostatistical Methods And Applications In Clinical Oncology written by Shigeyuki Matsui and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-03 with Medical categories.

This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.

Handbook Of Survival Analysis

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Author : John P. Klein
language : en
Publisher: CRC Press
Release Date : 2016-04-19

Handbook Of Survival Analysis written by John P. Klein and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Mathematics categories.

Handbook of Survival Analysis presents modern techniques and research problems in lifetime data analysis. This area of statistics deals with time-to-event data that is complicated by censoring and the dynamic nature of events occurring in time. With chapters written by leading researchers in the field, the handbook focuses on advances in survival analysis techniques, covering classical and Bayesian approaches. It gives a complete overview of the current status of survival analysis and should inspire further research in the field. Accessible to a wide range of readers, the book provides: An introduction to various areas in survival analysis for graduate students and novices A reference to modern investigations into survival analysis for more established researchers A text or supplement for a second or advanced course in survival analysis A useful guide to statistical methods for analyzing survival data experiments for practicing statisticians

Evidence Based Medicine To Inform Practice Assessing Clinical Effectiveness And Economic Burden Of Medicine

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Author : Kevin Lu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-08

Evidence Based Medicine To Inform Practice Assessing Clinical Effectiveness And Economic Burden Of Medicine written by Kevin Lu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-08 with Medical categories.

Handbook Of Statistics In Clinical Oncology

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Author : John Crowley
language : en
Publisher: CRC Press
Release Date : 2012-03-26

Handbook Of Statistics In Clinical Oncology written by John Crowley and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-26 with Mathematics categories.

Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials. Accessible to statisticians in clinical trials as well as oncologists interested in clinical trial methodology, the book presents up-to-date statistical approaches to the design and analysis of oncology clinical trials. New topics in this edition include trial designs for targeted agents, Bayesian trial design, and the inclusion of high-dimensional data and imaging techniques. This edition also contains numerous figures and examples to better explain concepts.