Current Applications For Overcoming Resistance To Targeted Therapies
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Current Applications For Overcoming Resistance To Targeted Therapies
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Author : Myron R. Szewczuk
language : en
Publisher: Springer
Release Date : 2019-07-15
Current Applications For Overcoming Resistance To Targeted Therapies written by Myron R. Szewczuk and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-15 with Medical categories.
Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome.
Resistance In Hematologic Malignancies And Cancer
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Author : Lucia Messingerova
language : en
Publisher: Elsevier
Release Date : 2024-10-29
Resistance In Hematologic Malignancies And Cancer written by Lucia Messingerova and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-29 with Science categories.
Resistance in Hematologic Malignancies and Cancer brings together the molecular, cellular, and biochemical basis/principles of various mechanisms of resistance to treatment in hematologic malignancies.Even though main mechanisms of resistance are the same in different types of tumours there are specific signalling pathways involved in resistance in hematological malignancies and of course specific treatmentsIn 11 chapters, Resistance in Hematologic Malignancies and Cancer describes the development of treatment resistance in hematological malignancies, the role of MiRNA in resistance, the role of the immune system in resistance prediction, as well as the latest knowledge from clinical research.It gives insight in the complex information about different mechanisms linkage in final loss of cell sensitivity to drug treatment, the orientation in metabolic pathways that could be involved in depressed leukemia cell resistance to drugs and gives information about causes of drug resistance in leukemia cells.By the multidisciplinary approach of the processing this book is a valuable resource for both health professionals, scientists and researchers, health practitioners, students, but will also enable members of the general professional public to orientate themselves in issues that are not directly in their area of expertise - Describes the different mechanisms of resistance; cooperation in net resistance to antileukemic drugs - Provides hallmark information about cell regulation pathways in drug resistance development - Brings information about causes of drug resistance in leukemia and hematologic malignancies including lymphoma and myeloma
Drug Delivery Devices And Therapeutic Systems
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Author : Eric Chappel
language : en
Publisher: Academic Press
Release Date : 2020-11-07
Drug Delivery Devices And Therapeutic Systems written by Eric Chappel and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-07 with Medical categories.
Drug Delivery Devices and Therapeutic Systems examines the current technology and innovations moving drug delivery systems (DDS) forward. The book provides an overview on the therapeutic use of drug delivery devices, including design, applications, and a description of the design of each device. While other books focus on the therapy, the primary emphasis in this book is on current technologies for DDS applications, including microfluidics, nanotechnology, biodegradable hydrogel and microneedles, with a special emphasis on wearable DDS. As part of the Developments in Biomedical Engineering and Bioelectronics series, this book is written by experts in the field and informed with information directly from manufacturers. Pharmaceutical scientists, medical researchers, biomedical engineers and clinical professionals will find this an essential reference. - Provides essential information on the most recent drug delivery systems available - Explains current technology and its applications to drug delivery - Contains contributions from biomedical engineers, pharmaceutical scientists and manufacturers
Lung Cancer An Issue Of Surgical Oncology Clinics Of North America
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Author : Mark J. Krasna
language : en
Publisher: Elsevier Health Sciences
Release Date : 2016-07-06
Lung Cancer An Issue Of Surgical Oncology Clinics Of North America written by Mark J. Krasna and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-06 with Medical categories.
This issue of Surgical Oncology Clinics of North America, guest edited by Dr. Mark Krasna, is devoted to Lung Cancer. Dr. Krasna has assembled expert authors to review the following topics: Epidemiology for Lung Cancer; Screening for Lung Cancer; Pathology for Lung Cancer; Treatment of Patients with Oligometastatic Disease for NSCLC; SBRT/Ablative Therapies for NSCLC; Mediastinal Staging for Lung Cancer; VATS Lobectomy for NSCLC; Robotic Lung Resection for NSCLC; Pneumonectomy for NSCLC; Bronchoscopy-Diagnostic and Therapeutic for NSCLC; Neoadjuvant Therapy for Lung Cancer; Molecular/Targeted Therapy for Lung Cancer; Adjuvant Therapy for Stage 1and 2 NSCLC, and more!
Intestinal Metaplasia Pathophysiology Diagnosis And Comprehensive Management
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Author : Dr. Spineanu Eugenia
language : en
Publisher: Dr. Spineanu Eugenia
Release Date : 2025-02-19
Intestinal Metaplasia Pathophysiology Diagnosis And Comprehensive Management written by Dr. Spineanu Eugenia and has been published by Dr. Spineanu Eugenia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-19 with Medical categories.
"Intestinal Metaplasia: Pathophysiology, Diagnosis, and Comprehensive Management" is an in-depth medical treatise that explores the complex condition of intestinal metaplasia. This authoritative resource delves into the anatomy, cellular biochemistry, and histological features of the gastrointestinal tract, providing a thorough understanding of the mechanisms behind metaplasia. It covers essential topics such as genetic and epigenetic factors, environmental influences, and the molecular pathways involved. The treatise also offers detailed sections on clinical evaluation, diagnostic imaging, and histopathological examination. Treatment strategies, including pharmacological interventions, surgical options, and emerging therapies, are extensively discussed. Additionally, it emphasizes the importance of lifestyle modifications, such as diet, exercise, and stress management, in managing intestinal metaplasia. Designed for medical professionals, researchers, and students, this comprehensive guide combines current research findings with practical insights, making it an indispensable resource for understanding and managing this condition.
Malignant Gliomas Rmr V3 I2
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Author : Arnab Chakravarti, MD
language : en
Publisher: Demos Medical Publishing
Release Date : 2012-10-09
Malignant Gliomas Rmr V3 I2 written by Arnab Chakravarti, MD and has been published by Demos Medical Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-09 with Medical categories.
Radiation Medicine Rounds is a trinary, hard cover periodical designed to provide an up-to-date review of a dedicated radiation medicine topic of interest to clinicians and scientists who are involved in the care of patients receiving radiotherapy. It is intended to serve as both a reference and instructional tool for students, housestaff, fellows, practicing clinicians, medical physicists, cancer biologists, radiobiologists, and interdisciplinary colleagues throughout the oncology spectrum. This issue of Radiation Medicine Rounds discusses the more salient topics surrounding the role of radiation therapy for malignant gliomas. The specialty of radiation therapy has increased in complexity over the years, yet as technology improves, the goal of improving outcomes while decreasing toxicity remains critical. Malignant gliomas remain among the most devastating of all malignancies, yet as conventional treatments (surgery, radiation, and chemotherapy) have become optimized overall survival has improved. The underlying molecular and genetic mechanisms of these tumors are becoming better understood, with one of the most important realizations being that histopathologically identical malignant gliomas often demonstrate very distinct clinical behaviors. Malignant Gliomas provides the practitioner with a current overview of best practices, recent research, and future directions in the management of this complex and challenging cancer. "
Clinical Application Of Repurposed Drugs
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-06-29
Clinical Application Of Repurposed Drugs written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-29 with Science categories.
Clinical Application of Repurposed Drugs, Volume 207 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on Drug repurposing for viral disease, Drug repurposing for bacterial infections, Drug repurposing for parasitic protozoan diseases, Drug repurposing for fungal infections, Drug repurposing for treating anxiety and depression, Drug repurposing for personalized medicine, Drug repurposing for cancer, Drug Repurposing: A multi targeted approach to treat cardiac disease from existing classical drugs to modern drug discovery, and much more. Additional chapters cover Drug repurposing in MASLD and MASH-cirrhosis: targets and treatment approaches based on pathways analysis, Drug repurposing for respiratory infections, Drug repurposing for rare disease, Drug repurposing for neurological disorders, Drug repurposing for metabolic disorders: scientific, technological and economic issues, Drug repurposing for regenerative medicine and cosmetics: scientific, technological and economic issues, and Exploring Cutting-Edge Omics-Driven Strategies for Drug Repurposing – An Insight into the Tools of the Trade. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Progress in Molecular Biology and Translational Science series - Includes the latest information on Clinical Applications of Repurposed Drugs
Liposarcoma Comprehensive Insights Into Pathogenesis Diagnosis And Management
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Author : Dr. Spineanu Eugenia
language : en
Publisher: Dr. Spineanu Eugenia
Release Date : 2025-02-19
Liposarcoma Comprehensive Insights Into Pathogenesis Diagnosis And Management written by Dr. Spineanu Eugenia and has been published by Dr. Spineanu Eugenia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-19 with Medical categories.
Liposarcoma: Comprehensive Insights into Pathogenesis, Diagnosis, and Management is an extensive treatise offering a detailed exploration of liposarcoma, a rare and complex malignancy. This authoritative volume delves into the latest advancements in understanding liposarcoma's molecular mechanisms, genetic mutations, and tumor biology. It provides a thorough analysis of diagnostic techniques, including imaging and histopathology, and evaluates cutting-edge treatment strategies such as surgery, radiotherapy, chemotherapy, and novel targeted therapies. Emphasizing a holistic approach, the treatise also covers the role of nutrition, psychological support, and long-term management for improved patient outcomes. Designed for oncologists, researchers, and medical professionals, this comprehensive resource integrates current knowledge with practical insights, ensuring a deep understanding of liposarcoma's multifaceted aspects. Perfect for those seeking an in-depth review of this challenging cancer and its management strategies.
Drug Resistance In Cancer Mechanisms And Strategies
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Author : Sameer Ullah Khan
language : en
Publisher: Springer Nature
Release Date : 2024-05-06
Drug Resistance In Cancer Mechanisms And Strategies written by Sameer Ullah Khan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-06 with Medical categories.
This book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates. In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options.
Mtor Inhibitors Advances In Research And Application 2013 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-06-21
Mtor Inhibitors Advances In Research And Application 2013 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-21 with Medical categories.
MTOR Inhibitors—Advances in Research and Application: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about ZZZAdditional Research in a compact format. The editors have built MTOR Inhibitors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of MTOR Inhibitors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.