Current Challenges In Modeling Cellular Metabolism

DOWNLOAD

Download Current Challenges In Modeling Cellular Metabolism PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Current Challenges In Modeling Cellular Metabolism book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Current Challenges In Modeling Cellular Metabolism

DOWNLOAD
Author : Daniel Machado
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-21

Current Challenges In Modeling Cellular Metabolism written by Daniel Machado and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-21 with Biology (General) categories.

Mathematical and computational models play an essential role in understanding the cellular metabolism. They are used as platforms to integrate current knowledge on a biological system and to systematically test and predict the effect of manipulations to such systems. The recent advances in genome sequencing techniques have facilitated the reconstruction of genome-scale metabolic networks for a wide variety of organisms from microbes to human cells. These models have been successfully used in multiple biotechnological applications. Despite these advancements, modeling cellular metabolism still presents many challenges. The aim of this Research Topic is not only to expose and consolidate the state-of-the-art in metabolic modeling approaches, but also to push this frontier beyond the current edge through the introduction of innovative solutions. The articles presented in this e-book address some of the main challenges in the field, including the integration of different modeling formalisms, the integration of heterogeneous data sources into metabolic models, explicit representation of other biological processes during phenotype simulation, and standardization efforts in the representation of metabolic models and simulation results.

Linking Cellular Metabolism To Hematological Malignancies

DOWNLOAD
Author : Jian Yu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-05

Linking Cellular Metabolism To Hematological Malignancies written by Jian Yu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-05 with Medical categories.

Systems Biology

DOWNLOAD
Author : Aleš Prokop
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-08-28

Systems Biology written by Aleš Prokop and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-28 with Medical categories.

Growth in the pharmaceutical market has slowed down – almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies – the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing to produce the innovation needed for success. This multi-authored new book looks at a vital strategy which can bring innovation to a market in need of new ideas and new products: Systems Biology (SB). Modeling is a significant task of systems biology. SB aims to develop and use efficient algorithms, data structures, visualization and communication tools to orchestrate the integration of large quantities of biological data with the goal of computer modeling. It involves the use of computer simulations of biological systems, such as the networks of metabolites comprise signal transduction pathways and gene regulatory networks to both analyze and visualize the complex connections of these cellular processes. SB involves a series of operational protocols used for performing research, namely a cycle composed of theoretical, analytic or computational modeling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory.

Current Progress In Ipsc Disease Modeling

DOWNLOAD
Author : Alexander Birbrair
language : en
Publisher: Academic Press
Release Date : 2021-11-11

Current Progress In Ipsc Disease Modeling written by Alexander Birbrair and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-11 with Science categories.

Current Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in the field. This new volume addresses advances in research on how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions once impossible for some human diseases. This volume addresses iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids, and more. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field. - Provides an overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics - Covers advances in research on how induced pluripotent stem cells are used to create new tissues/organs - Contributed by world-renowned experts in the field

Comprehensive Biotechnology

DOWNLOAD
Author :
language : en
Publisher: Elsevier
Release Date : 2019-07-17

Comprehensive Biotechnology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-17 with Science categories.

Comprehensive Biotechnology, Third Edition, Six Volume Set unifies, in a single source, a huge amount of information in this growing field. The book covers scientific fundamentals, along with engineering considerations and applications in industry, agriculture, medicine, the environment and socio-economics, including the related government regulatory overviews. This new edition builds on the solid basis provided by previous editions, incorporating all recent advances in the field since the second edition was published in 2011. Offers researchers a one-stop shop for information on the subject of biotechnology Provides in-depth treatment of relevant topics from recognized authorities, including the contributions of a Nobel laureate Presents the perspective of researchers in different fields, such as biochemistry, agriculture, engineering, biomedicine and environmental science

Systems Biology And The Challenge Of Deciphering The Metabolic Mechanisms Underlying Cancer

DOWNLOAD
Author : Osbaldo Resendis-Antonio
language : en
Publisher: Frontiers Media SA
Release Date : 2017-11-23

Systems Biology And The Challenge Of Deciphering The Metabolic Mechanisms Underlying Cancer written by Osbaldo Resendis-Antonio and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-23 with categories.

Since the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as apoptosis or detection by the immune system. However, the strategies by which this is achieved in different cancers and sometimes even in different patients of the same cancer is very heterogeneous, which hinders the design of general treatment options. Recently, there has been an ongoing effort to study this phenomenon on a genomic scale in order to understand the causality underlying the disease. Hence, current “omics” technologies have contributed to identify and monitor different biological pieces at different biological levels, such as genes, proteins or metabolites. These technological capacities have provided us with vast amounts of clinical data where a single patient may often give rise to various tissue samples, each of them being characterized in detail by genomescale data on the sequence, expression, proteome and metabolome level. Data with such detail poses the imminent problem of extracting meaningful interpretations and translating them into specific treatment options. To this purpose, Systems Biology provides a set of promising computational tools in order to decipher the mechanisms driving a healthy cell’s metabolism into a cancerous one. However, this enterprise requires bridging the gap between large data resources, mathematical analysis and modeling specifically designed to work with the available data. This is by no means trivial and requires high levels of communication and adaptation between the experimental and theoretical side of research.

T Cell Regulation By The Environment

DOWNLOAD
Author : Anne L. Astier
language : en
Publisher: Frontiers Media SA
Release Date : 2015

T Cell Regulation By The Environment written by Anne L. Astier and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Immunologic diseases. Allergy categories.

Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation. Parasite infection can also skew Th differentiation. Similarly, the gut microbiota regulates the development of immune responses. Lastly, the key role of metabolism on T cells has also been demonstrated. This series of articles highlights some of the multiple links existing between environmental factors and T cell responses.

Biomechanical Modelling At The Molecular Cellular And Tissue Levels

DOWNLOAD
Author : Gerhard A. Holzapfel
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-05

Biomechanical Modelling At The Molecular Cellular And Tissue Levels written by Gerhard A. Holzapfel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-05 with Technology & Engineering categories.

Issues In Biotechnology And Medical Technology Research And Application 2011 Edition

DOWNLOAD
Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09

Issues In Biotechnology And Medical Technology Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Science categories.

Issues in Biotechnology and Medical Technology Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biotechnology and Medical Technology Research and Application. The editors have built Issues in Biotechnology and Medical Technology Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biotechnology and Medical Technology Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biotechnology and Medical Technology Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Biology And Control Theory Current Challenges

DOWNLOAD
Author : Isabelle Queinnec
language : en
Publisher: Springer
Release Date : 2007-08-07

Biology And Control Theory Current Challenges written by Isabelle Queinnec and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-07 with Technology & Engineering categories.

Creating some links between control feedback and biology modeling communities based on similarities in modeling, observing and perceiving alive structures, and analyzing interconnections between biological structures and subsystems was the main objective of this volume. In this context, biology systems need appropriate analysis tools due to their structure and hierarchy, complexity and environment interference, and we believe that these aspects may generate interesting research topics in control area. Indeed, several works, raising the potential impact of control developments to bring some beginning of answers in the context of biological systems, have been published in the recent years. The idea of this book was conceived in the context mentioned above with the objective to help in claiming many of the problems for control researchers, starting discussions and opening interactive debates between the control and biology communities, and, finally, to alert graduate students to the many interesting ideas at the frontier between control feedback theory and biology.