Current Concepts In Autoimmunity And Chronic Inflammation
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Current Concepts In Autoimmunity And Chronic Inflammation
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Author : Andreas Radbruch
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-09-08
Current Concepts In Autoimmunity And Chronic Inflammation written by Andreas Radbruch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-08 with Medical categories.
The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of “horror autotoxicus” is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result in central or peripheral deletion or the alteration of functional potential. In addition, there are in?uences that are extrinsic to potentially auto-reactive lymphocytes, including the function of regulatory cells, d- ferentiation state of antigen-presenting cells, availability of self-antigen, the cytokine and chemokine milieu, as well as the traf?cking patterns involved in generating productive immune interactions. It is clear that the immune system devotes a considerable effort to the avoidance of the development of potentially pathogenic self-reactivity. Despite this, the development of self-reactivity is relatively common. - though the development of autoimmune disease is less frequent, autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus e- thematosus, psoriasis, thyroiditis, and myasthenia gravis, are all too common, and can cause considerable morbidity and even mortality.
Current Concepts In Autoimmunity And Chronic Inflammation
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Author : Andreas Radbruch
language : en
Publisher: Springer
Release Date : 2009-09-02
Current Concepts In Autoimmunity And Chronic Inflammation written by Andreas Radbruch and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-02 with Medical categories.
The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of “horror autotoxicus” is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result in central or peripheral deletion or the alteration of functional potential. In addition, there are in?uences that are extrinsic to potentially auto-reactive lymphocytes, including the function of regulatory cells, d- ferentiation state of antigen-presenting cells, availability of self-antigen, the cytokine and chemokine milieu, as well as the traf?cking patterns involved in generating productive immune interactions. It is clear that the immune system devotes a considerable effort to the avoidance of the development of potentially pathogenic self-reactivity. Despite this, the development of self-reactivity is relatively common. - though the development of autoimmune disease is less frequent, autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus e- thematosus, psoriasis, thyroiditis, and myasthenia gravis, are all too common, and can cause considerable morbidity and even mortality.
Trends In Inflammatory Bowel Disease Therapy 1999
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Author : C. Noel Williams
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Trends In Inflammatory Bowel Disease Therapy 1999 written by C. Noel Williams and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This Trends in Inflammatory Bowel Disease Therapy Symposium was held in Vancouver, British Columbia, Canada, 27~29 August 1999. This is the seventh international symposium, sponsored by Axcan Pharma Canada Inc., since the first symposium in 1986. The Canadian Association of Gastroenterology has co-sponsored these symposia since 1990. Each symposium has been published, and reflects and updates the extensive research and education, and the understanding of the mechanisms and treatment of inflammatory bowel disease. From the beginning, Canadian and international experts have been involved, maintaining a consistently high quality, both in their presentations, during discussions, and the subsequent publication of their work. There have been major advances since the symposium held two years ago, and these are presented in this book. In keeping with modern educational practice, objectives are provided, and all presentations were subject to written independent evalu ation. All participants are asked to declare any conflicts of interest. MOCOMP and educational credits are available.
Immune Regulation And Immunotherapy In Autoimmune Disease
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Author : Jingwu Zhang
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-25
Immune Regulation And Immunotherapy In Autoimmune Disease written by Jingwu Zhang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-25 with Medical categories.
This book critically reviews both clinical and immunological aspects of auto- mune disease with a strong emphasis on multiple sclerosis (MS). Research in MS is one of the fastest-developing areas in modern medicine. It employs some of the newest concepts in autoimmune mechanisms and an array of new treatments that would have been considered science fiction only two decades ago. It is an area in which research findings are being actively translated into treatment strategies. Advances in this area have both clinical and scientific implications for other autoimmune conditions that share many similarities with MS. The book, which comprises 24 chapters contributed by experts and thought leaders in the field, is designed to provide new insights into two arenas: our current understanding of autoimmune mechanisms and immune regulation and the latest developments in immunotherapy. This book is intended for both researchers and clinicians. Its purpose is not only to provide a comprehensive review on the recent advances in the two arenas m- tioned above but also to reflect the current opinions or concepts that influence our thinking about the disease mechanisms and our way of treating MS patients. Many of these issues have emerged from recent studies and are somewhat contradictory to traditional thinking. For example, recent studies have indicated that MS is more heterogeneous in many aspects than traditionally thought. Pathologically, in ad- tion to demyelination and inflammation, there is axonal loss or damage detectable in the central nervous system (CNS) lesions.
Recent Advances In Veterinary Immunology Concepts And Methodology
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Author : Armin Saalmueller
language : en
Publisher: Frontiers Media SA
Release Date : 2021-03-03
Recent Advances In Veterinary Immunology Concepts And Methodology written by Armin Saalmueller and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-03 with Medical categories.
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Autoimmunity And Chronic Inflammation In Early Life
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Author : Ravi Misra
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-29
Autoimmunity And Chronic Inflammation In Early Life written by Ravi Misra and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-29 with Medical categories.
Recent Advances In Immunology To Target Cancer Inflammation And Infections
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Author : Jagat Kanwar
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-05-09
Recent Advances In Immunology To Target Cancer Inflammation And Infections written by Jagat Kanwar and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-09 with Medical categories.
Immunology is the branch of biomedical sciences to study of the immune system physiology both in healthy and diseased states. Some aspects of autoimmunity draws our attention to the fact that it is not always associated with pathology. For instance, autoimmune reactions are highly useful in clearing off the excess, unwanted or aged tissues from the body. Also, generation of autoimmunity occurs after the exposure to the non-self antigen that is structurally similar to the self, aided by the stimulatory molecules like the cytokines. Thus, a narrow margin differentiates immunity from auto-immunity as already discussed. Hence, finding answers for how the physiologic immunity turns to pathologic autoimmunity always remains a question of intense interest. However, this margin could be cut down only if the physiology of the immune system is better understood. The individual chapters included in this book will cover all the possible aspects of immunology and pathologies associated with it. The authors have taken strenuous effort in elaborating the concepts that are lucid and will be of reader's interest.
Immunotherapy Magic Bullet To Change The Future Therapeutics
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Author :
language : en
Publisher: Elsevier
Release Date : 2025-02-24
Immunotherapy Magic Bullet To Change The Future Therapeutics written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-24 with Science categories.
FORMTEXT Immunotherapy is emerging as a novel and reliable therapeutic technique for treating diseases such as autoimmunity, HIV/AIDS, allergy and cancers. Immunotherapy change or modulate our immune system functionalization and activate it to kill pathogen infected cells or affected cells. Development in the field of Immunology, Molecular Biology, and Pharmaceutical Sciences empower the immune system for protecting us agaist number of pathogenic infections. This volume consisit of the chapters from the different stalwarts of the field coveriing the topic such as Immunotherapy past and present, Oncolytic virus based therapy, CAR-T cell therapy, antibody engineering, adjuvant engineering etc. Chapters covered in this volume discuss the immunological translational research in the field of human cancer, parasitic and infectiouds diseases. This volume incudes the chapter describing the tools developed by scientist to engineers safe and effective antibody which can be used as powerful medicine durig human disease conditions. This volume will reflect the secret of biological sciences and technology in the field on immunology to develop safe and efficacious immune molecules based magic bullet to provide absolute cure. This volume will be helpful to the early career researchers and students working in the field of basic and applied immunological sciences. - Immunotherapy - Monoclonal antibody - Cytokines
The Heart In Rheumatic Autoimmune And Inflammatory Diseases
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Author : Udi Nussinovitch
language : en
Publisher: Academic Press
Release Date : 2017-02-10
The Heart In Rheumatic Autoimmune And Inflammatory Diseases written by Udi Nussinovitch and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-10 with Medical categories.
The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe. - A review of common, as well as unusual (yet clinically significant) medical cardiac complications of prevalent rheumatic, autoimmune and inflammatory diseases. - Focuses on aspects of pathophysiological processes, clinical presentations, screening tests, prognostic implications and novel therapeutic approaches. - Presents an up-to-date "level of evidence and "strengths of recommendations for suggested therapies and reviews all randomized clinical trials, meta-analyses and other supporting published clinical findings.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1972
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1972 with Medicine categories.