Current Topics In Complement Ii
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Current Topics In Complement Ii
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Author : John D. Lambris
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-04
Current Topics In Complement Ii written by John D. Lambris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-04 with Medical categories.
Complement has long been regarded as a pivotal effector arm of the innate immune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or Inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspective. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits. In this respect, scientists from around the world convened at the Fourth Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10-15, 2007), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the “novel” functions of complement, patho-physiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.
Current Topics In Complement Ii
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Author : John D. Lambris
language : en
Publisher: Springer
Release Date : 2008-11-01
Current Topics In Complement Ii written by John D. Lambris and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-01 with Medical categories.
Complement has long been regarded as a pivotal effector arm of the innate immune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or Inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspective. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits. In this respect, scientists from around the world convened at the Fourth Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10-15, 2007), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the “novel” functions of complement, patho-physiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.
Current Topics In Complement
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Author : John D. Lambris
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-26
Current Topics In Complement written by John D. Lambris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-26 with Medical categories.
The Third Aegean Conferences Workshop on Complement-Associated Diseases, Animal Models, and Therapeutics convened to discuss progress in complement research as it pertains to human disease pathogenesis and therapeutics. The rapid pace of research and new experimental approaches allow an integrated view of the in vivo biology of the complement system. This book collects writings on the functions of complement, pathophysiology, protein structures, design of complement inhibitors, and complement assays discussed at the conference.
The Complement Factsbook
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Author : Scott R. Barnum
language : en
Publisher: Academic Press
Release Date : 1999-10-28
The Complement Factsbook written by Scott R. Barnum and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-10-28 with Medical categories.
The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies. Includes the cDNA sequences, marked with intron/exon boundaries, facilitating genetic studies Presents detailed structural information including cDNA and gene structure for all proteins Introduces complement function, simply described for each function Data is as up-to-date as possible, including unpublished work from many contributors Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, familiesEach chapter has been written by an expert in the field Data is as up-to-date as possible, including unpublished work from many contributors Entries provide information on: Alternative nomenclature, Physiochemical properties, Structure and function, Tissue distribution and regulation expression, Protein sequence/modules, Chromosomal location, Genomic structure, Database accession numbers, Deficiency and polymorphic variants, Key references
The Complement System
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Author : Mihaela Gadjeva
language : en
Publisher: Humana
Release Date : 2016-08-23
The Complement System written by Mihaela Gadjeva and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Medical categories.
Complement Systems: Methods and Protocols is composed of 32 individual chapters that describe a variety of protocols to purify and analyze the activity of the individual complement components or pathways. It includes assays that describe detection of complement SNPs, clinical methods to evaluate complement system activation and data interpretation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Complement Systems: Methods and Protocols provides a collection of well-established “classical” assays and recently developed “new” assays to analyze the complement system activation will be useful to a wide audience of scientists.
Current Topics In Anemia
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Author : Jesmine Khan
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-02-07
Current Topics In Anemia written by Jesmine Khan and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-07 with Medical categories.
This book deals with a very common condition, anemia, which might interest not only the physicians but also other healthcare professionals and researchers dealing with anemic patients. The objective of this book was to collect and compile up-to-date information from reputable researchers of different countries of the world to disseminate the latest information about the common types of anemia in some specific physiological and pathological conditions including pathophysiology and the use of algorithms as a tool to minimize the laboratory tests and accurate diagnosis of the underlying cause. In total, there are 13 chapters in this book where the authors shared their research findings and real-life experiences in managing their patients with anemia.
Molecular Mechanisms In Spermatogenesis
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Author : C.Y. Cheng
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-24
Molecular Mechanisms In Spermatogenesis written by C.Y. Cheng and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-24 with Science categories.
In the past thirty years, significant advances have been made in the field of reproductive biology in unlocking the molecular and biochemical events that regulate spermatogenesis in the mammalian testis. It was possible because of the unprecedented breakthroughs in molecular biology, cell biology, immunology, and biochemistry. In this book entitled, Molecular Mechanisms in Spermatogenesis, a collection of chapters has been included written by colleagues on the latest development in the field using genomic and proteomic approaches to study spermatogenesis, as well as different mechanisms and/or molecules including environmental toxicants and transcription factors that regulate and/or affect spermatogenesis. The book begins with a chapter that provides the basic concept of cellular regulation of spermatogenesis. A few chapters are also dedicated to some of the latest findings on the Sertoli cell cytoskeleton and other molecules (e.g., proteases, adhesion proteins) that regulate spermatogenesis. These chapters contain thought-provoking discussions and concepts which shall be welcomed by investigators in the field. It is obvious that many of these concepts will be updated and some may be amended in the years to come. However, they will serve as a guide and the basis for investigation by scientists in the field.
Cellular Transplantation
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Author : Craig Halberstadt
language : en
Publisher: Elsevier
Release Date : 2011-10-10
Cellular Transplantation written by Craig Halberstadt and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-10 with Science categories.
There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. Provides detailed description of clinical trials in cell transplantation Review of current therapeutic approaches Coverage of the broad range of diseases addressed by cell therapeutics Discussion of stem cell biology and its role in transplantation
The Human Complement System In Health And Disease
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Author : John E. Volanakis
language : en
Publisher: CRC Press
Release Date : 1998-02-25
The Human Complement System In Health And Disease written by John E. Volanakis and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-02-25 with Medical categories.
This authoritative, single-source reference provides comprehensive examinations of the complement system-offering recent findings in basic science on the structure, biology, physiology, and pathophysiology of complement proteins and the latest therapeutic approaches towards the control of complement-mediated diseases. Written by over 40 international experts from North America, Europe, and Asia, The Human Complement System in Health and Disease describes the molecular architecture of the complement system details the structure of complement genes discusses gene organization as well as the topology and chemistry of ligand-binding sites and catalytic centers of complement proteins analyzes complement organization and activation, including phylogeny and the newly discovered lectin pathway elucidates the regulation of complement gene expression and the structure and function of bioactive peptides explicates opsonic and immunoregulatory properties of complement fragments, endothelial responses, and interactions with viruses and bacteria and more!
Current Topics In Microbiology And Immunology
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Author : W. Arber
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-08
Current Topics In Microbiology And Immunology written by W. Arber and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Medical categories.