Current Trends In Targeted And Non Targeted Metabolomics In Analytical Toxicology
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Current Trends In Targeted And Non Targeted Metabolomics In Analytical Toxicology
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Author : Geraldine M. Dowling
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-19
Current Trends In Targeted And Non Targeted Metabolomics In Analytical Toxicology written by Geraldine M. Dowling and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-19 with Science categories.
This article collection emphasizes the substantial potential and versatility of metabolomic technologies in clarifying biological mechanisms, discovering biomarkers, and distinguishing pathological conditions. Several studies highlighted metabolomics applied to traditional medicine. Metabolomics profiling also effectively contributed to forensic investigations, improving accuracy in estimating post-mortem intervals through metabolite time-dependency and robustness against external factors like anticoagulants. Furthermore, metabolomic studies elucidated biochemical responses to pharmaceutical agents, illustrated by assessments of colistin-induced nephro- and neurotoxicity at therapeutic doses. Investigations into metabolic fingerprints provided insights into nutritionally influenced health conditions (obesity-related fat distribution) and infectious diseases (such as pediatric tuberculous meningitis) pinpointing significant biomarkers and metabolic pathways. Finally, advancements in analytical methods, particularly ion mobility and multidimensional chromatography coupled with mass spectrometry, were reviewed, reinforcing their important role and future promise in increasing resolution, sensitivity, and interpretability of metabolomic data.
Forensic Chemistry
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Author : Suzanne Bell
language : en
Publisher: CRC Press
Release Date : 2022-04-27
Forensic Chemistry written by Suzanne Bell and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-27 with Law categories.
Forensic Chemistry, Third Edition, the new edition of this ground-breaking book, continues to serve as the leading forensic chemistry text on the market. Fully updated, this edition describes the latest advances in current forensic chemistry analysis and practice. New and expanded coverage includes rapid advances in forensic mass spectrometry, NMR, and novel psychoactive substances (NPSs). Topics related to seized drug analysis, toxicology, combustion and fire investigation, explosives, and firearms discharge residue are described and illustrated with case studies. The role of statistics, quality assurance/quality control, uncertainty, and metrology are integrated into all topics. More pharmacological and toxicokinetic calculations are presented and discussed. Hundreds of color figures, nearly 450 total, along with graphs, illustrations, worked example problems, and case descriptions are used to show how analytical chemistry is applied to forensic practice. Coverage offer students insight into the legal context in which forensic chemistry is conducted and introduces them to the sample types and sample matrices frequently encountered in forensic laboratories.
Comprehensive Toxicology
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Author :
language : en
Publisher: Elsevier
Release Date : 2017-12-01
Comprehensive Toxicology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-01 with Science categories.
Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
New Insights In Microbial Stress Tolerance Mechanisms
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Author : Z. Petek Cakar
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-26
New Insights In Microbial Stress Tolerance Mechanisms written by Z. Petek Cakar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-26 with Science categories.
Microorganisms are ubiquitous and can be found in various environments, ranging from extreme habitats like deep-sea hydrothermal vents, arctic glaciers, and outer space to more common environments such as soil, water, and the human gut. These microorganisms are exposed to diverse stressors, including temperature fluctuations, pH changes, toxin exposure, and nutrient deprivation, antimicrobial agents and host immune responses, which can threaten survival. However, many microorganisms have evolved numerous stress tolerance mechanisms that enable them to adapt and thrive in these challenging environments.
Bioanalytical Techniques
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Author : Inamuddin
language : en
Publisher: John Wiley & Sons
Release Date : 2025-08-08
Bioanalytical Techniques written by Inamuddin and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-08 with Technology & Engineering categories.
The book provides a comprehensive guide that covers the fundamental principles and methodologies of essential bioanalytical techniques. Bioanalytical Techniques: Principles and Applications is a comprehensive and authoritative book that explores the principles, methodologies, and applications of bioanalytical techniques in the field of life sciences. The book covers a wide range of analytical techniques used for the characterization, quantification, and analysis of biological samples, including proteins, nucleic acids, metabolites, and biomarkers. Using a multidisciplinary approach by integrating concepts from biochemistry, molecular biology, analytical chemistry, and biotechnology, this book provides a solid foundation in the fundamental principles underlying various bioanalytical techniques, such as spectroscopy, chromatography, electrophoresis, immunoassays, mass spectrometry, and biosensors. Each technique is explained in detail, including its working principles, instrumentation, data analysis, and practical considerations. The book incorporates case studies, examples, and practical tips to illustrate how these techniques are used to solve biological problems and address research questions. It also discusses emerging trends and technologies in bioanalytical techniques, such as microfluidics, nanotechnology, and omics approaches. Readers will find the book: Offers comprehensive coverage of bioanalytical techniques, encompassing a wide range of methodologies, instruments, and applications through real-world case studies; Adopts a multidisciplinary approach, integrating concepts from biochemistry, molecular biology, analytical chemistry, and biotechnology; Explores emerging trends and technologies in bioanalytical techniques, such as microfluidics, nanotechnology, omics approaches, and bioinformatics; Includes practical guidance, troubleshooting tips, and common challenges in bioanalysis, equipping readers with valuable insights and strategies for successful experimentation and data interpretation; Features contributions from renowned experts and leaders in the field, ensuring the content is authoritative, up-to-date, and reflects the latest advancements in bioanalytical techniques. Audience Biochemists, biologists, chemists, and medical and pharmaceutical professionals interested in biomolecules, enzymology, and biochemical pathways.
Genetics Meets Metabolomics
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Author : Karsten Suhre
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-15
Genetics Meets Metabolomics written by Karsten Suhre and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-15 with Medical categories.
This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.
Traditional Medicines And Natural Products For Gut X Axis Pharmacology Toxicology And Microbiology In The Context Of Drug Discovery And Herbal Medicine Use Volume Ii
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Author : Xiaoxiao Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-28
Traditional Medicines And Natural Products For Gut X Axis Pharmacology Toxicology And Microbiology In The Context Of Drug Discovery And Herbal Medicine Use Volume Ii written by Xiaoxiao Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-28 with Science categories.
The gut is one of the most versatile organs for humans and animals. In recent years, more and more research has revealed that the gut has close relationships with many other organs, such as the liver, kidneys, lungs, brain, and breasts. Gut microbes have close relationships with their hosts and play an important role in the physiological activities of humans and animals. More and more research has revealed that gut microbes can adjust the functions of the hosts' major organs, such as the liver, kidneys, brain, lungs, and breasts. In other words, the Gut-X Axis has become a hot research topic in recent years. Herbal medicines have been used globally in the treatment of human and animal diseases for thousands of years. Traditional Chinese herbal medicines, such as Glycyrrhiza spp. and Astragalus membranaceus Bunge, are examples of botanical drugs that have significant effects on the treatment of immune depression by adjusting the gut microbe. Silybum marianum, originally distributed in the Mediterranean and other parts of Southern Europe and Northern Africa, is now widely used to treat various liver diseases and modify the gut microbe. The active natural products in traditional Chinese medicine have also been studied on the Gut-X Axis, such as Atractylodes macrocephala polysaccharide (AMP). Therefore, research on the pharmacology, toxicology, microbiology, and action mechanism of traditional medicines and active natural products via the Gut-X Axis is essential to better understand their efficacy and to expand the development of drugs for the treatment of clinical diseases.
Environmental Metabolomics
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Author : Diana Alvarez-Munoz
language : en
Publisher: Elsevier
Release Date : 2020-05-19
Environmental Metabolomics written by Diana Alvarez-Munoz and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-19 with Science categories.
Environmental Metabolomics Applications in Field and Laboratory Studies: From the Exposome to the Metabolome presents an overview of the current state of aquatic environments and problems caused by human pressure and daily life. The presence of contaminants in nature and their effects are evaluated, along with recommendations for preservation. This book not only shows readers how to implement techniques, it also guides them through the process. As metabolomics becomes a more routine technique for environmental studies and future perspectives, a guide for validation and globalization of current approaches is needed. - Presents relevant and reliable information on the use of different analytical techniques for establishing the environmental metabolomics of polluted systems - Includes a critical review of each central topic in every chapter, together with a bibliography and future trends - Provides, for the first time, a global opinion and guide for achieving standardized results
Metagenomics For Microbiology
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Author : Jacques Izard
language : en
Publisher: Academic Press
Release Date : 2025-09-01
Metagenomics For Microbiology written by Jacques Izard and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-09-01 with Science categories.
Metagenomics for Microbiology, Second Edition unveils the intricate and diverse world of microbial communities, emphasizing their critical roles in health, disease, and ecosystem functionality. This updated edition addresses the significant challenges in the field and introduces promising approaches to make metagenomics research more feasible. Through comprehensive revisions and over five new chapters, readers are equipped with the latest research data and analyses, advancing their understanding of microbial principles. Notably, this edition provides a robust foundation for the design and analysis of omics studies, focusing on technological underpinnings and practical applications. It remains an essential resource for characterizing microbial consortia. - Describes updated methodologies with best-practice prescription, from sample to data analysis, for current metagenomic studies - Updates on sample preparation, data production, data clean up, data analysis, statistics, and experimental biology, with accompanying descriptions - Includes a new chapter on long read applications using Nanopore technology - Provides a new chapter on probability distributions that underpin the structure of microbiome ecosystems - Covers bio surveillance of diseases and biodefense
Toxicology For The Health And Pharmaceutical Sciences
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Author : Antonio Peña-Fernández
language : en
Publisher: CRC Press
Release Date : 2021-12-21
Toxicology For The Health And Pharmaceutical Sciences written by Antonio Peña-Fernández and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-21 with Medical categories.
There is an increasing need for knowledge of toxicology to safeguard the use of chemicals in industry and in the public and private sectors. The study of toxicology is becoming increasingly relevant in human health sciences, as future health and clinical professionals will be pivotal in addressing and managing emerging chemical threats and hazards related to modern anthropogenic activities and technological development. Comprising a series of chapters from leading toxicology, pharmacy and public health academics and experts across Europe, the United States and beyond, Toxicology for the Health and Pharmaceutical Sciences provides a concise yet comprehensive volume that can be used as a relevant textbook on toxicology for the clinical, healthcare, educational and professional sectors. Key Features: Includes cutting edge information regarding the very lastest environmental threats to public health Provides a detailed case study based on a real-world scenario that allows the reader to practice human health risk assessment Describes innovative guidance and tools to respond to chemical incidents and attacks, which enables the reader to tailor an effective protection and remediation response This book covers the fundamentals and recent developments in toxicology, to respond to local and global chemical, pharmaceutical and environmental threats. Thus, this volume has chapters specifically designed to support the understanding of the most current toxicology-related subjects for any undergraduate/postgraduate health programs as well as aid the delivery of continuing professional development training on up-to-date topics in toxicology for current practicing health professionals wishing to improve their background knowledge in toxicology. The book is also vital reading and reference for policy makers and others that influence and set regulations that have an impact on the environment and human health.