Cutaneous Lupus Erythematosus Landscape Pathophysiology Unmet Needs And Related Challenges In Clinical Practice What Is On The Horizon
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Cutaneous Lupus Erythematosus Landscape Pathophysiology Unmet Needs And Related Challenges In Clinical Practice What Is On The Horizon
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Author : Nathalie Marie Franchimont
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-06
Cutaneous Lupus Erythematosus Landscape Pathophysiology Unmet Needs And Related Challenges In Clinical Practice What Is On The Horizon written by Nathalie Marie Franchimont and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-06 with Medical categories.
CLE (Cutaneous Lupus Erythematosus) is an autoimmune disease that can occur with or without systemic manifestations; people with CLE may experience symptoms including photosensitivity, rash, pain, and pruritis as well as skin damage that may worsen over time and can include disfiguring and irreversible scarring alopecia and skin dyspigmentation. Patients with CLE may frequently suffer from comorbidities as depression and cardiovascular disease as well as functional, mental, and emotional HRQoL (health-related quality of life) impairment associated with substantial healthcare expenditures.
Pathogenesis Of Systemic Lupus Erythematosus
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Author : Alberta Hoi
language : en
Publisher: Springer Nature
Release Date : 2021-11-15
Pathogenesis Of Systemic Lupus Erythematosus written by Alberta Hoi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-15 with Medical categories.
The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.
Scleroderma
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Author : John Varga
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-21
Scleroderma written by John Varga and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-21 with Medical categories.
This essential book examines the most up-to-date information on scleroderma, offering a clear and concise synthesis of current concepts in pathogenesis and modern approaches to management. Presents a multidisciplinary approach to scleroderma care.
Biologics Biosimilars And Biobetters
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Author : Iqbal Ramzan
language : en
Publisher: John Wiley & Sons
Release Date : 2021-02-03
Biologics Biosimilars And Biobetters written by Iqbal Ramzan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-03 with Medical categories.
A comprehensive primer and reference, this book provides pharmacists and health practitioners the relevant science and policy concepts behind biologics, biosimilars, and biobetters from a practical and clinical perspective. Explains what pharmacists need to discuss the equivalence, efficacy, safety, and risks of biosimilars with physicians, health practitioners, and patients about Guides regulators on pragmatic approaches to dealing with these drugs in the context of rapidly evolving scientific and clinical evidence Balances scientific information on complex drugs with practical information, such as a checklist for pharmacists
Paediatric Rheumatology
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Author : Helen E. Foster
language : en
Publisher: OUP Oxford
Release Date : 2012-06-14
Paediatric Rheumatology written by Helen E. Foster and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-14 with Medical categories.
Paediatric Rheumatology is an indispensible resource for the identification and management of specific rheumatological disorders. As well as covering common and rare rheumatological problems, there are also chapters on investigations and emergencies, designed for quick reference. The handbook includes dedicated topics on systemic diseases affecting rheumatology; the relevant clinical guidelines and information needed for a rheumatologist to successfully management a young patient; and, a coloured section for guidance on rash-related investigations. Paediatric Rheumatology is also fully endorsed by the British Society for Paediatric and Adolescent Rheumatology and the UK Paediatric Rheumatology Clinical Studies Group.
The First Outstanding 50 Years Of Universit Politecnica Delle Marche
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Author : Sauro Longhi
language : en
Publisher: Springer Nature
Release Date : 2020-01-03
The First Outstanding 50 Years Of Universit Politecnica Delle Marche written by Sauro Longhi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-03 with Science categories.
The book describes significant multidisciplinary research findings at the Università Politecnica delle Marche and the expected future advances. It addresses some of the most dramatic challenges posed by today’s fast-growing, global society and the changes it has caused, while also discussing solutions to improve the wellbeing of human beings. The book covers the main research achievements made in the social sciences and humanities, and includes chapters that focus on understanding mechanisms that are relevant to all aspects of economic and social interactions among individuals. In line with Giorgio Fuà’s contribution, the interdisciplinary research being pursued at the Faculty of Economics of Università Politecnica delle Marche is aimed at interpreting the process of economic development in all of its facets, both at the national and local level, with a particular focus on profit and non-profit organizations. Various disciplines are covered, from economics to sociology, history, statistics, mathematics, law, accounting, finance and management.
Pediatric Rheumatic Diseases
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Author : Virginia Wright
language : en
Publisher:
Release Date : 2000
Pediatric Rheumatic Diseases written by Virginia Wright and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Children categories.
Occupational therapists who work with adults with neurological problems must be able to appropriately and quickly use a variety of screening methods to pinpoint deficit areas and assess how these have impaired the person's daily life function. This comprehensive book compiles the most common occupational therapy screening methods used with adults with neurological conditions. Presented as a step-by-step instruction manual, the book includes copies of all screens and is presented in an easy-to-use format that facilitates its use in the clinic and in home health and community-based settings. It is also an ideal text for students, clearly outlining how to administer neurological screens in occupational therapy practice. Extensive use of photographs enhances the instructions and clearly shows practitioners how to use the various techniques. Book jacket.
Human Viruses Diseases Treatments And Vaccines
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Author : Shamim I. Ahmad
language : en
Publisher: Springer Nature
Release Date : 2021-05-19
Human Viruses Diseases Treatments And Vaccines written by Shamim I. Ahmad and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-19 with Medical categories.
This book discusses current evidence on human viruses and provides an extensive coverage of newly emerged viruses and current strategies for treatment. Offering a new perspective in view of the re-emergence of Ebola in African countries and Dengue in India and Pakistan, the contents include chapters on emergence, pathogenicity, epidemiology and vaccine uptake. Human Viruses: Diseases, Treatments and Vaccines: The New Insights discusses a range of viruses from the most common such as Influenza and Hepatitis to Zika, Poliomyelitis and Chikungunya among many others. It is authored by a team of experts on viral disease and will be of immense use to virologists, public health experts and clinicians.
Immunopharmacology And Inflammation
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Author : Carlo Riccardi
language : en
Publisher: Springer
Release Date : 2018-06-09
Immunopharmacology And Inflammation written by Carlo Riccardi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-09 with Medical categories.
A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.
Infections In Hematology
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Author : Georg Maschmeyer
language : en
Publisher: Springer
Release Date : 2014-12-13
Infections In Hematology written by Georg Maschmeyer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-13 with Medical categories.
Infections are among the most frequent complications in patients with hematological malignancies and in those undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation. A profound knowledge on the epidemiology, diagnostic approaches, treatment modalities and prophylactic strategies is essential for the clinical management of these complications in patients who are often severely immunocompromised owing to their underlying diseases and in particular, the intensive myelosuppressive chemo and immunotherapy. This textbook provides a clinically oriented, compact and up-to-date overview on infections in hematology patients and their management. The typical pathogens to be considered in different subgroups of patients are identified and further aspects of the microbiological background are explored. Clinical, imaging, and laboratory-based diagnostic techniques are discussed and therapeutic strategies appropriate to different situations are then presented, with due attention to the pitfalls, toxicities and interactions that can arise during antimicrobial treatment. Strategies to prevent infection are also outlined, encompassing antimicrobial prophylaxis, isolation procedures, hospital hygiene, protective immunization and the use of hematopoietic growth factors.