Cycloadditions In Bioorthogonal Chemistry
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Cycloadditions In Bioorthogonal Chemistry
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Author : Milan Vrabel
language : en
Publisher: Springer
Release Date : 2016-05-28
Cycloadditions In Bioorthogonal Chemistry written by Milan Vrabel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-28 with Science categories.
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
Cycloadditions In Bioorthogonal Chemistry
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Author : David Phillips
language : en
Publisher: Createspace Independent Publishing Platform
Release Date : 2017-03-08
Cycloadditions In Bioorthogonal Chemistry written by David Phillips and has been published by Createspace Independent Publishing Platform this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-08 with categories.
Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.
Cycloadditions In Bioorthogonal Chemistry
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Author : John Paquette
language : en
Publisher: Createspace Independent Publishing Platform
Release Date : 2017-03-14
Cycloadditions In Bioorthogonal Chemistry written by John Paquette and has been published by Createspace Independent Publishing Platform this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-14 with categories.
The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed.
Role Of Distortion Energy And Steric Effects On Cycloadditions In Bioorthogonal Chemistry
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Author : Steven Alexander Lopez
language : en
Publisher:
Release Date : 2013
Role Of Distortion Energy And Steric Effects On Cycloadditions In Bioorthogonal Chemistry written by Steven Alexander Lopez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
The 1,3-dipolar cycloaddition and Diels-Alder reaction have been applied countless times in synthetic organic chemistry, materials chemistry, and now chemical biology. The stereoselectivity and rapid kinetics have been harnessed to develop the field of bioorthogonal chemistry. In this thesis, the origins of the rapid kinetics and exo-facial selectivity of norbornene was explained and extended to a series of pyramidalized norbornenes and sesquinorbornenes. These were studied using DFT (Density Functional Theory) at the M06-2X/6-311G(d, p) level along with other computational models. The transition structures and activation barriers for these reactions were calculated. An analysis of the calculations revealed that distortion energy is greatly responsible for the observed stereoselectivity, and a simple relationship was derived between pyramidalization and activation barriers. We propose the term, distortion-accelerated, to describe why the reactions are fast, rather than strain-promoted, because the alkenes release most of their strain energy before the transition state. In a second portion of the thesis I applied the concept of distortion-acceleration to a recently discovered mutually orthogonal 1,3-dipolar cycloaddition and an inverse-demand Diels-Alder reaction. Mutually orthogonal reactions were used in the literature to selectively label two different cancer cells simultaneously. We explained this selectivity difference using modern computational methodology. DFT was used for this computational investigation at the M06-2X/6-311+G(d, p) level and the Polarizable Continuum Model (PCM) was used to correct for solvation effects. It was found that distortion energy, LUMO energies, and steric effects are responsible for the observed selectivity. General rules were developed to easily predict new mutually orthogonal pairs once their bioorthogonality is known.
Modern Applications Of Cycloaddition Chemistry
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Author : Paolo Quadrelli
language : en
Publisher: Elsevier
Release Date : 2019-03-20
Modern Applications Of Cycloaddition Chemistry written by Paolo Quadrelli and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-20 with Science categories.
Modern Applications of Cycloaddition Chemistry examines this area of organic chemistry, with special attention paid to cycloadditions in synthetic and mechanistic applications in modern organic chemistry. While many books dedicated to cycloaddition reactions deal with the synthesis of heterocycles, general applications, specific applications in natural product synthesis, and the use of a class of organic compounds, this work sheds new light on pericyclic reactions by demonstrating how these valuable tools elegantly solve synthetic and mechanistic problems. The work examines how pericyclic reactions have been extensively applied to different chemistry areas, such as chemical biology, biological processes, catalyzed cycloaddition reactions, and more. This work will be useful for organic chemists who deal with organic chemistry, medicinal chemistry, agrochemistry and material chemistry. Provides details on the synthesis of antiviral and anticancer compounds, marking the key role of unconventional catalyzed cycloaddition reactions for preparing new derivatives in a unique reaction pathway that is scalable in industrial processes Contains the most up-to-date review of the use of pericyclic reactions in drug delivery Includes the enzyme-catalyzed processes involving cycloaddition reactions for different targets, demonstrating that cycloaddition is more common in nature than expected Features new applications for cycloadditions in material chemistry and provides a general view of the most recent results in the area
Synthetic Applications Of 1 3 Dipolar Cycloaddition Chemistry Toward Heterocycles And Natural Products Volume 59
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Author : Albert Padwa
language : en
Publisher: John Wiley & Sons
Release Date : 2003-04-14
Synthetic Applications Of 1 3 Dipolar Cycloaddition Chemistry Toward Heterocycles And Natural Products Volume 59 written by Albert Padwa and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-04-14 with Science categories.
Dipolar cycloaddition reactions have found many useful applications in chemistry, particularly with respect to the synthesis of compounds with new chiral centers. Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products updates the popular 1984 edition, featuring the advances made over the past twenty years and focusing on synthetic applications.
Cycloaddition Reactions In Organic Synthesis
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Author : W. Carruthers
language : en
Publisher: Elsevier Science & Technology
Release Date : 1990
Cycloaddition Reactions In Organic Synthesis written by W. Carruthers and has been published by Elsevier Science & Technology this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Science categories.
Paperback. Demonstrates the wide scope of cycloaddition reactions, including the Diels-Alder reaction, the ene reaction, 1,3-dipolar cycloadditions and [2]2] cycloadditions in organic synthesis. The author, a leading exponent of the subject, illustrates the ways in which they can be employed in the synthesis of a wide range of carbocyclic and heterocyclic compounds, including a variety of natural products of various types. Special attention is given to intramolecular reactions, which often provide a rapid and efficient route to polycyclic compounds, and to the stereochemistry of the reactions, including recent and developing work on enantioselective synthesis.
Synthesis Of Heterocycles Via Cycloadditions Ii
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Author : Alfred Hassner
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-07-21
Synthesis Of Heterocycles Via Cycloadditions Ii written by Alfred Hassner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-21 with Science categories.
See Table of Contents (PMP)
Advances In Cycloaddition
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Author : Michael Harmata
language : en
Publisher: Elsevier
Release Date : 1999-03-18
Advances In Cycloaddition written by Michael Harmata and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-03-18 with Science categories.
The development and application of cycloaddition methodology continues to be at the forefront of research in synthetic organic chemistry. This volume begins with a review of methods available for the synthesis of seven-membered rings and is followed with work on metal-catalyzed cycloadditions. There is then an update on the cycloaddition chemistry of 2-pyrone, and then a unique application of photocycloaddition is detailed. The final chapter is a discussion of the latest explorations of the reaction of rhodium-stabilized vinyl carbenoids with dienes.
Methods And Applications Of Cycloaddition Reactions In Organic Syntheses
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Author : Nagatoshi Nishiwaki
language : en
Publisher: John Wiley & Sons
Release Date : 2013-12-17
Methods And Applications Of Cycloaddition Reactions In Organic Syntheses written by Nagatoshi Nishiwaki and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-17 with Science categories.
Advanced tools for developing new functional materials and applications in chemical research, pharmaceuticals, and materials science Cycloadditions are among the most useful tools for organic chemists, enabling them to build carbocyclic and heterocyclic structures. These structures can then be used to develop a broad range of functional materials, including pharmaceuticals, agrochemicals, dyes, and optics. With contributions from an international team of leading experts and pioneers in cycloaddition chemistry, this book brings together and reviews recent advances, trends, and emerging research in the field. Methods and Applications of Cycloaddition Reactions in Organic Syntheses focuses on two component cycloadditions, with chapters covering such topics as: N1 unit transfer reaction to C–C double bonds [3+2] Cycloaddition of α, β-unsaturated metal-carbene complexes Formal [3+3] cycloaddition approach to natural product synthesis Development of new methods for the construction of heterocycles based on cycloaddition reaction of 1,3-dipoles Cycloreversion approach for preparation of large π-conjugated compounds Transition metal-catalyzed or mediated [5+1] cycloadditions Readers will learn methods for seamlessly executing important reactions such as Diels-Alder and stereoselective dipolar reactions in order to fabricate heterocyclic compounds, natural products, and functional molecules. The book not only features cutting-edge topics, but also important background information, such as the contributors’ process for developing new methodologies, to help novices become fully adept in the field. References at the end of each chapter lead to original research papers and reviews for facilitating further investigation of individual topics. Covering the state of the science and technology, Methods and Applications of Cycloaddition Reactions in Organic Syntheses enables synthetic organic chemists to advance their research and develop new functional materials and applications in chemical research, pharmaceuticals, and materials science.