Cytokine Inhibitors
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Novel Cytokine Inhibitors
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Author : Gerry A. Higgs
language : en
Publisher: Springer
Release Date : 2012-12-06
Novel Cytokine Inhibitors written by Gerry A. Higgs and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cytokines have become established as key mediators of the signs and symptoms of inflammatory diseases such as arthritis, dermatitis, asthma and multiple sclerosis. Furthermore, they are involved in the cascade of events leading to cardiovascular shock and are major regulators of the function of immune cells. This book reviews recent advances in the development of new anti-inflammatory drugs. It addresses different therapeutic intervention possibilities for new drugs, such as the cellular source of cytokines, specific receptors which induce cytokine synthesis, intracellular regulators of cytokine gene induction and expression, secretion and activation of cytokines, cytokine receptors and signalling pathways from these receptors. Accordingly, experts were drawn from different backgrounds including academic research institutes, the pharmaceutical industry and clinical pharmacology. In each area, the opportunities for drug development are highlighted and, where possible, clinical data is reviewed.
Cytokine Inhibitors
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Author : Gennaro Ciliberto
language : en
Publisher: CRC Press
Release Date : 2000-11-14
Cytokine Inhibitors written by Gennaro Ciliberto and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-11-14 with Medical categories.
Compiling an up-to-date and detailed survey of the role cytokines play in cell-to-cell communication, development, and differentiation, this comprehensive reference highlights the medical advantages of cytokine inhibition and pursues novel methods of discovery for more potent and specific blocking agents. Investigates the pathogenic role of cytokines and the potential of cytokine inhibitors as anti-inflammatory, anticancer, antiviral agents! Written by 25 recognized experts revealing recent breakthroughs in research, Cytokine Inhibitors illustrates cases of naturally produced or in vitro engineered polypeptide cytokine blocking agents describes all possible approaches to cytokine inhibitors, including monoclonal antibodies, soluble receptors, engineered mutant cytokines, and small-molecular-weight receptor antagonists and signaling inhibitors clearly explains the homeostatic function of cytokine inhibition and verifies therapeutic approaches effecting natural responses in organisms discusses the results of clinical trials and therapeutic applications of first-generation recombinant receptor antagonists, such as the potential of tumor necrosis factor antagonists as prominent tools in the therapy of chronic inflammatory conditions concentrates on the clinical development of second-generation small-molecular-weight, orally bioavailable cytokine inhibitors reviews the improved understanding of intracellular signaling pathways, the structural determinants responsible for cytokine-receptor interaction lists the three-dimensional structure, relevant receptors, and intracellular tyrosine kinases of cytokines and much more! Containing over 1400 references as well as tables and drawings, Cytokine Inhibitors serves as an exemplary reference for basic and clinical immunologists; allergists; biochemists; pathologists, hematologists; experimental, cell, and molecular biologists; rheumatologists; infectious disease specialists; medicinal chemists; and medical school and upper-level undergraduate and graduate students in these disciplines.
Novel Cytokine Inhibitors
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Author : G. A. Higgs
language : en
Publisher:
Release Date : 2000
Novel Cytokine Inhibitors written by G. A. Higgs and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Anti-inflammatory agents categories.
Cytokines And Cytokine Inhibitors
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Author :
language : en
Publisher:
Release Date : 1992
Cytokines And Cytokine Inhibitors written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Cytokines categories.
Therapeutic Modulation Of Cytokines
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Author : M. W. Bodmer
language : en
Publisher: CRC Press
Release Date : 1996-01-23
Therapeutic Modulation Of Cytokines written by M. W. Bodmer and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-23 with Medical categories.
Cytokines are peptide or protein cell-to-cell signaling molecules that play vital roles in normal cell and tissue homeostasis, as well as in responses to infectious agents. Because of their importance in virtually all forms of pathology, the pharmaceutical industry is devoting great effort to develop methods for the control of cytokine synthesis or action. This is the first volume to bring together experts from academia and the pharmaceutical industry to discuss problems and solutions in the therapeutic control of cytokines. An introductory section reviews the biology, physiology, and pathology of cytokines. Internationally recognized scientists then discuss the development of low molecular mass inhibitors, including inhibitors of cytokine convertases and oligonucleotide drugs. The potential use of natural inhibitors such as soluble receptors, interleukin-1 receptor antagonists, and anti-cytokine antibodies is detailed. This interesting book also covers intracellular signaling pathways induced by pro-inflammatory cytokines and the bio-modulatory activity of specific cytokines such as TGF-ß. Therapeutic Modulation of Cytokines will interest academic scientists in biochemistry, cell biology, pharmacology, and molecular biology and biological scientists in the pharmaceutical and biopharmaceutical industries.
Symposium Cytokines And Cytokine Inhibitors In Autoimmune Diseases
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Author : Symposium Cytokines and Cytokine Inhibitors in Autoimmune Diseases (1994, Toledo)
language : en
Publisher:
Release Date : 1994
Symposium Cytokines And Cytokine Inhibitors In Autoimmune Diseases written by Symposium Cytokines and Cytokine Inhibitors in Autoimmune Diseases (1994, Toledo) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
Cytokines And Cytokine Inhibitors
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Author :
language : en
Publisher:
Release Date : 1992
Cytokines And Cytokine Inhibitors written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Cytokines And Cytokine Inhibitors In Autoimmune Diseases
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Author : European Society for Clinical Investigation
language : en
Publisher:
Release Date : 1995
Cytokines And Cytokine Inhibitors In Autoimmune Diseases written by European Society for Clinical Investigation and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Cytokines And Cytokine Inhibitors
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Author :
language : en
Publisher:
Release Date : 1992
Cytokines And Cytokine Inhibitors written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Symposium
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Author : European Society for Clinical Investigation. Meeting
language : en
Publisher:
Release Date : 1994
Symposium written by European Society for Clinical Investigation. Meeting and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Autoimmune disease categories.