Cytokines And Colony Stimulating Factors
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Cytokines And Colony Stimulating Factors
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Author : Dieter Körholz
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Cytokines And Colony Stimulating Factors written by Dieter Körholz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Medical categories.
The immune system is a complex network in which different cell types and soluble factors interact to efficiently eliminate various kinds of microorganisms as well as aberrant cell clones. The roots of immunologic investigations reach far into the past. In 430 BC, Thucydides reported that survivors of the plague did not present a second time with similar symptoms. The first report of a successful immu- therapy was made by Edward Jenner in 1798 who found a protective effect of cowpox vaccination against human pox. Since then, much knowledge has been accumulated; today, investigations of the molecular mechanisms of immune regulation are of central research interest. The novel insights into gene polymorphisms and gene regulation gathered from this work has improved our knowledge of individual immune reactions and risk factors in overcoming infections. Strategies to use the immune system for cancer treatment have been propelled by the discovery of divergent immunoregulatory cytokines and the introduction of new gene therapy strategies to modify immune responses. Recently, the discovery of various dendritic cells has focused attention on these cell types as central elements of the immune response and to the possibility of dendritic cell expansion, maturation, and consecutive stimulation with immuno- active tumor-specific peptides. Similarly, methods for ex vivo expansion of various stem cell-derived cell types have led to an improved therapeutic management of various benign and malignant diseases.
Clinical Applications Of Cytokines And Growth Factors
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Author : John R. Wingard
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Clinical Applications Of Cytokines And Growth Factors written by John R. Wingard and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off of invading microbes by humoral, cell-mediated, and phagocytic immunity. The activity of the hematopoietic system is staggering: daily, a normal adult produces approximately 2.5 billion erythrocytes, 2.5 billion platelets, and 1 billion granulocytes per kilogram of body weight. This production is adjusted in a timely fashion to changes in actual needs and can vary from nearly none to many times the normal rate depending on needs which vary from day to day, or even minute to minute. In response to a variety of stimuli, the cellular components of the blood are promptly increased or decreased in production to maintain appropriate numbers to optimally protect the host from hypoxia, infection, and hemorrhage. How does this all happen and happen without over or under responding? There has been extraordinary growth in our understanding ofhematopoiesis over the last two decades. Occupying center stage is the pluripotent stern cell and its progeny. Hematopoietic stern cells have been characterized by their capacity for self renewal and their ability to proliferate and differentiate along multiple lineages. Few in number, the stern cell gives rise to all circulating neutrophils, erythrocytes, lymphoid cells, and platelets. In hematopoietic transplantation, the stern cell is capable of restoring long-term hematopoiesis in a lethally irradiated host.
Colony Stimulating Factors
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Author : John M. Garland
language : en
Publisher: CRC Press
Release Date : 2020-08-26
Colony Stimulating Factors written by John M. Garland and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Science categories.
Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.
Growth Factors Differentiation Factors And Cytokines
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Author : Andreas Habenicht
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Growth Factors Differentiation Factors And Cytokines written by Andreas Habenicht and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Leading international experts contribute to this selection of reviews covering the merging fields of growth factors, differentiation factors, and cytokines. These appear to play fundamental roles in a wide variety of physiological and pathophysiological processes that include the regulation of growth in normal and malignant cells, embryogenesis, the immune response, wound healing, inflammation, and atherogenesis. The major aspects of recent research and development are discussed, providing an important update in this pioneering field.
The Hemopoietic Colony Stimulating Factors
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Author : Donald Metcalf
language : en
Publisher: Cambridge University Press
Release Date : 1995-02-24
The Hemopoietic Colony Stimulating Factors written by Donald Metcalf and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-02-24 with Medical categories.
A detailed account for cell biologists and clinicians of the colony-stimulating factors.
Clinical Applications Of Cytokines
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Author : Joost J. Oppenheim
language : en
Publisher: Oxford University Press, USA
Release Date : 1993
Clinical Applications Of Cytokines written by Joost J. Oppenheim and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Cytokines categories.
The driving force for research on cytokines has always been their clinical promise. Their biological properties suggested a key role in hematopoiesis, immunity, tumor genesis, hemostasis, vascularization, repair of connective tissues and integration of the immune system with the neuroendocrine system. Animal studies have shown that cytokines could be used as effective biotherapeutics with easily manageable and reversible toxicities. Clinical trials have confirmed these findings, culminating in the licensing of a number of the cytokines such as interferon alpha, interferon gamma, interleukin 2, erythropoietin, granulocyte colony stimulating factor, and granulocyte-macrophage colony stimulating factor. Many other cytokines are in clinical trials. This is the first comprehensive volume on the cytokines written primarily from a medical perspective. After presenting background information about the structure, production, assays and systemic effects of cytokines and their receptors, it is organized around diseases and organ systems. Infectious diseases, autoimmunity, immunodeficiency states, defective hematopoiesis, allergies, injury repair, cancer, vascular and skin diseases, and neurological disorders are all covered. This work reviews the role that cytokines play in the pathogenesis, diagnosis and therapy of each disease. The authors assess both the current state of the art and the potential for future applications.
The Cytokine Handbook Two Volume Set
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Author : Angus W. Thomson
language : en
Publisher: Elsevier
Release Date : 2003-04-22
The Cytokine Handbook Two Volume Set written by Angus W. Thomson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-04-22 with Medical categories.
The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics. Key Features* Covers all main cytokines and chemokines * Written by experts* Up-to-date- includes detailed referencing accessing current, modern literature and reflects the newest findings from the human genome * The new edition has been thoroughly revised and extended (now 2 volumes) as compared to the last edition, including new co-editor (MTL), new authors, new hot topics and new chapters* Includes major emphasis on clinical applications* Extensively illustrated with tables and figures
Xenobiotics And Inflammation
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Author : Schook
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Xenobiotics And Inflammation written by Schook and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
The affect of xenobiotics on host resistance in general and specific immune functions has become the focus of much current research. This book synthesises current information on how chemicals (xenobiotics) can affect the immune system to cuse dysfunction, focusing on the process of inflammation. It provides a much needed, single-source reference for researchers investigation the mechanisms responsible for altered host resistance following exposture to xenobiotics. Emphasis is placed on the roles of cytokines and growth factors in the inflammatory process and how such processes are altered and modulated by xenobiotics. This volume contains information pertinent to those exploring cell growth, angiogenesis, hematopoetic differentiation, and recruitment to and proliferation of cells in various tissue sites. This volume brings together experts in inflammation, cytokines, cell growth, immunology and toxicology to provide a highly yseful volume modulated by chemicals. Divided into three sections, the book offers an organ system approach to understanding inflammation and xenobiotics.
Cytokines
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Author : C. Bondy
language : en
Publisher: Elsevier
Release Date : 1997-04-18
Cytokines written by C. Bondy and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-04-18 with Science categories.
Progress in molecular technology in recent years has caused an amazing growth of information about intercellular peptide messengers and their receptors. The number of characterized interleukins for example numbered just three six years ago and now there are at least 16. In addition, the number of described neutrophic peptides is around 30 and the number of receptors is ever increasing. Because many of these new peptide ligands and receptors were identified by "reverse genetic" techniques the understanding of their biological roles falls behind the knowledge of their molecular structures. However a new strain of functional studies has begun and animal models are developed allowing for further research into the biological roles of these messenger peptides and their receptors. Cytokines, the theme of this volume, describes a group of proteins identified primarily within the immune and hematopoietic systems. As many cytokines as possible are included along with their receptors providing the reader with a guide to an ever-changing field of scientific research.
The Cytokine Handbook
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Author : Angus W. Thomson
language : en
Publisher:
Release Date : 1998
The Cytokine Handbook written by Angus W. Thomson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
The Third Edition of the Cytokine Handbook provides encyclopedic coverage of the hemopoietic growth factors and the interleukin and interferon families of molecules, cytokine by cytokine. This new edition is completely revised to bring the reader the most up-to-date information on all of the important cytokines and cytokine receptors with the inclusion of new members of the interleukin family (up to IL-18), in depth treatment of cytokine receptors, as well as individual chapters on stem cell factor and flt3 ligand, gene therapy, and the chemokines. The Cytokine Handbook explains in detail the immunology and molecular biology of these molecules and their receptors, and discusses in additional chapters their therapeutic potential, assay systems, and phylogeny. It is written in an easy-to-follow style and includes an extensive bibliography. This book is a must for the library of any researcher or clinician interested in, or bewildered by, the diversity of cytokines. Key Features * Up-to-date material includes new members of the interleukin family (up to IL-18) * In-depth treatment of cytokine receptors * Individual chapters on stem cell factor and flt3 ligand, gene therapy, and the chemokines
