Cytokines And Growth Factors In Blood Transfusion
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Cytokines And Growth Factors In Blood Transfusion
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Author : C.Th. Smit Sibinga
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cytokines And Growth Factors In Blood Transfusion written by C.Th. Smit Sibinga and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cytokines are cellular growth factors which also provide communication between cells and their milieu. This clearly is an exciting area in modern medicine that will have significant impact on various facets of transfusion. Erythropoietin therapy stimulates red cell production while thrombopoietin seems to positively affect megakaryopoiesis and can be an added armamentarium for the thrombocytopenic patient. Using haematnopoietic growth factors, stem cells could be mobilized early to the peripheral blood for collection and subsequent transplantation into haemato-oncology patients instead of bone marrow transplantation. Using a cocktail of cytokines in cell culture, stem cells could be expanded and selected for therapy. Cytokines and growth factors can even be modified, which may lead to successful gene therapy in malignancies, including solid tumour vaccines. However, the presence of cytokines in certain blood products could have biological effects following transfusion, although its clinical relevance needs to be ascertained. There is much potential for the use of cytokines in the treatment of infections. Early diagnostic methods are now available to monitor their levels and relevance. It is likely that cytokines will increasingly play a role in therapy and could develop our fundamental knowledge about the development of T-cells. An ethical dilemma remains, however, regarding the use of cytokines in healthy donors for harvesting suitable specific cells. Longer clinical observation will be necessary to gather the necessary information. Cytokines and growth factors in blood transfusion was the theme of the 21st International Symposium in Blood Transfusion, where twenty clinicians and scientists, experts in their own fields, were invited to update the above information. Their findings are presented in four sections in this volume: Fundamental aspects - cytokines in development of T-cells, growth factors in haematopoiesis, growth factor receptors and signal transduction, cytokine response in platelet and whole blood transfusions. Function, production and diagnosis – laboratory diagnostics of cytokines and growth factors, cytokines in blood components, cytokines and growth factors in cell expansions, cytokines for genetic modification towards gene therapy, progenitor cells from healthy donors. Application in clinical medicine – clinical relevance of cytokines in transfusion products, cytokines and growth factors in solid tumours, gene therapy in malignancies, vaccine strategies inducing T-cell immunity against tumours, cytokines in the treatment of infections, thrombopoietin and megakaryopoiesis. Future potential use in transfusion medicine – erythropoietin, immunotherapy, ethical aspects of the use of cytokines and growth factors in donors, potential of cytokines and growth factors in transfusion medicine.
Cytokines And Growth Factors In Blood Transfusion
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Author : C. Th Smit Sibinga
language : en
Publisher:
Release Date : 1997
Cytokines And Growth Factors In Blood Transfusion written by C. Th Smit Sibinga and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Blood categories.
Cytokines In Transfusion Medicine
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Author : Robertson D. Davenport
language : en
Publisher: American Association of Blood Banks (AABB)
Release Date : 1997
Cytokines In Transfusion Medicine written by Robertson D. Davenport and has been published by American Association of Blood Banks (AABB) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Biological response modifiers categories.
Clinical Applications Of Cytokines And Growth Factors
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Author : John R. Wingard
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Clinical Applications Of Cytokines And Growth Factors written by John R. Wingard and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off of invading microbes by humoral, cell-mediated, and phagocytic immunity. The activity of the hematopoietic system is staggering: daily, a normal adult produces approximately 2.5 billion erythrocytes, 2.5 billion platelets, and 1 billion granulocytes per kilogram of body weight. This production is adjusted in a timely fashion to changes in actual needs and can vary from nearly none to many times the normal rate depending on needs which vary from day to day, or even minute to minute. In response to a variety of stimuli, the cellular components of the blood are promptly increased or decreased in production to maintain appropriate numbers to optimally protect the host from hypoxia, infection, and hemorrhage. How does this all happen and happen without over or under responding? There has been extraordinary growth in our understanding ofhematopoiesis over the last two decades. Occupying center stage is the pluripotent stern cell and its progeny. Hematopoietic stern cells have been characterized by their capacity for self renewal and their ability to proliferate and differentiate along multiple lineages. Few in number, the stern cell gives rise to all circulating neutrophils, erythrocytes, lymphoid cells, and platelets. In hematopoietic transplantation, the stern cell is capable of restoring long-term hematopoiesis in a lethally irradiated host.
Cytokines In The Treatment Of Hematopoietic Failure
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Author : Arnold Ganser
language : en
Publisher: CRC Press
Release Date : 1998-09-03
Cytokines In The Treatment Of Hematopoietic Failure written by Arnold Ganser and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-09-03 with Medical categories.
Written by world experts in the field, this book presents up-to-date, in-depth coverage of hematopoietic growth factors and related cytokines that are currently being developed or used for managing congenital and acquired forms of chronic cytopenias. Summarizes important clinical trial data in a convenient tabulated format and provides fundamental knowledge on hematopoiesis physiology and regulation! Facilitating rational decision making and cost-effective treatment strategies, this clinically and disease-oriented work describes as well as assesses the benefits and limitations of hematopoietic growth factor and cytokine use in graft failure peripheral-blood progenitor cell transplantation chemotherapy- and radiotherapy-induced cytopenias in patients with solid tumors and hematological malignancies, including leukemias and myelodysplastic syndromes cytopenic states related to infectious conditions such as AIDS ex vivo expansion of hematopoietic progenitor cells post-operative procedures for bone marrow transplantation renal failure the neonate transfusion medicine and more! Supplemented with literature citations and drawings, Cytokines in the Treatment of Hematopoietic Failure is an essential resource for hematologists, oncologists, internists, radiotherapists, pediatricians, neonatologists, infectious disease specialists, nephrologists, immunologists, transfusion medicine specialists, researchers in pharmaceutical companies, and graduate and medical school students in these disciplines.
Alternative Approaches To Human Blood Resources In Clinical Practice
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Author : Cees Smit Sibinga
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-09-30
Alternative Approaches To Human Blood Resources In Clinical Practice written by Cees Smit Sibinga and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-09-30 with Medical categories.
Currently blood is a volatile issue. The safety of blood and the quantification of transfusion risks have been dominant themes that have stimulated the development of alternative approaches in this rapidly developing area. In clinical medicine conventional blood and its components are used in supportive therapies dependent on the choice of apparent uncritical trigger factors. A compounding factor is depth of prospective clinical trials for evidence. Such trials in critical care areas would be of enormous value, not only in recording adverse effects and under-transfusion, but also indicating the value of decision analysis and cost-effectiveness in transfusion practice. Alternative approaches include the use of cytokines, growth factors, humanised monoclonal antibodies, recombinant plasma factors, and buffy coat derived natural human interferons. These are being increasingly implemented in the clinic. Solutions for oxygen transport are being developed and fibrinogen coated microcapsules are being investigated for thrombocytopenia. In surgical patients, various crystalloid and colloid combinations are explored as volume replacements. To avoid allogeneic transfusions, beneficial blood saving methods include various strategies, such as autologous deposits, normovolemic haemodilution and various agents including aprotinin, tranecamic acid, desmopressin and erythropoietin, but their use in hospital shows considerable variations. That umbilical cord blood could be a significant source of allogeneic stem cells in related and unrelated transplantation is illustrated by the increasing number of cord blood banks in Europe and elsewhere. Future blood resources are likely to face several challenges: immediate challenges relate to increased regulatory and political oversights; intermediate solutions would offer some improvements in public health and alleviate public fear but probably not address the economic challenges thrust upon the medical care system. As we approach the year 2000, the major concerns about transfusion medicine remain its logistics, safety and effectiveness. This theme is presented in the proceedings of the 22nd International Symposium on Blood Transfusion, developed in 21 up-to-date topics, collected and discussed in four sections. This book will be of timely value to students, professionals and all others interested or involved in the field of transfusion medicine, whether clinical or related.
Cytokines And Growth Factors
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Author : M. K. Brenner
language : en
Publisher:
Release Date : 1994
Cytokines And Growth Factors written by M. K. Brenner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Cytokines categories.
Blood Cell Biochemistry
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Author : Anthony D. Whetton
language : en
Publisher: Springer Science & Business Media
Release Date : 1996-08-31
Blood Cell Biochemistry written by Anthony D. Whetton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-08-31 with Medical categories.
Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog ical situations (see below).
Hematopoietic Growth Factors In Clinical Applications Second Edition
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Author : Roland Mertelsmann
language : en
Publisher: CRC Press
Release Date : 1994-09-29
Hematopoietic Growth Factors In Clinical Applications Second Edition written by Roland Mertelsmann and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-09-29 with Medical categories.
The Second Edition contains a wealth of new information on cytokines and the self-renewal, proliferation, maturation, and state of activity of hematopoietic and immunological progenitor cells and their progeny-demonstrating their efficacy in treating disease states associated with hematopoietic failure or impaired blood cell function. Discusses the demonstrated and potential clinical benefits of hematopoietic growth factors, the economic consequences of using these agents, and various practical usage concerns!
Hematopoietic Growth Factors In Clinical Applications
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Author : Roland Mertelsmann
language : en
Publisher:
Release Date :
Hematopoietic Growth Factors In Clinical Applications written by Roland Mertelsmann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
The Second Edition contains a wealth of new information on cytokines and the self-renewal, proliferation, maturation, and state of activity of hematopoietic and immunological progenitor cells and their progeny-demonstrating their efficacy in treating disease states associated with hematopoietic failure or impaired blood cell function. Discusses the demonstrated and potential clinical benefits of hematopoietic growth factors, the economic consequences of using these agents, and various practical usage concerns!