Cytokines In Rheumatoid Arthritis Ra
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Cytokines In Rheumatoid Arthritis Ra
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Author : Selim Nalbant
language : en
Publisher:
Release Date : 2017
Cytokines In Rheumatoid Arthritis Ra written by Selim Nalbant and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medicine categories.
Cytokines In Rheumatoid Arthritis
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Author : Ann-Kristin Ulfgren
language : en
Publisher:
Release Date : 2000
Cytokines In Rheumatoid Arthritis written by Ann-Kristin Ulfgren and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Rheumatoid arthritis categories.
New Developments In The Pathogenesis Of Rheumatoid Arthritis
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Author : Lazaros Sakkas
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-02-22
New Developments In The Pathogenesis Of Rheumatoid Arthritis written by Lazaros Sakkas and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-22 with Medical categories.
The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.
Monoclonal Antibodies
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Author : Kresina
language : en
Publisher: CRC Press
Release Date : 2020-08-26
Monoclonal Antibodies written by Kresina and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Medical categories.
Presents a sampling of new and novel approaches to the amelioration of musculoskeletal disease pathology, emphasizing prevention and therapy. Where applicable, these new technologies are focused on their application to human autoimmune diseases, but the volume mainly discusses and details the use of
Cytokines And Joint Injury
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Author : Wim B. van den Berg
language : en
Publisher: Springer
Release Date : 2012-12-06
Cytokines And Joint Injury written by Wim B. van den Berg and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Spe cial attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. In addition to an outline of the role of established cytokines, such as TNF, IL-l and IL-6, new information is given on the novel cytokines IL-15, IL-17 and IL-18 and their positioning in the complex cytokine interplay. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. Together, the chapters provide a complete and balanced view on pivotal cytokines and joint pathology.
Study Of Cytokines In Canine Rheumatoid Arthritis
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Author : Assefa Wondimu Abebe
language : en
Publisher:
Release Date : 2002
Study Of Cytokines In Canine Rheumatoid Arthritis written by Assefa Wondimu Abebe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Il 1ra In The Treatment Of Rheumatoid Arthritis Pocketbook
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Author : Barry Bresnihan
language : en
Publisher: CRC Press
Release Date : 2001-12-20
Il 1ra In The Treatment Of Rheumatoid Arthritis Pocketbook written by Barry Bresnihan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-12-20 with Medical categories.
In recent years researchers have gained a greater understanding of the immunological and inflammatory mechanisms underlying rheumatoid arthritis. Much of their efforts have centred on the role of the cytokine network in the pathophysiology of the disease. On the basis of these discoveries pharmaceutical companies have developed several potential biologic agents aimed at addressing cytokine imbalance and its subsequent effects on cartilage damage and joint destruction in rheumatoid arthritis. This pocketbook will provide an overview of the role of cytokines in the disease process, with a particular focus on one cytokine, interleukin-1 (IL-1) and on the therapeutic efficacy of its inhibition.
Autoantibodies And Cytokines In Pathogenesis Of Rheumatoid Arthritis
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Author : Mohd Wajid Ali Khan
language : en
Publisher:
Release Date : 2019
Autoantibodies And Cytokines In Pathogenesis Of Rheumatoid Arthritis written by Mohd Wajid Ali Khan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Medical categories.
Rheumatoid arthritis (RA) is an autoimmune disorder in which increased autoantibody production and enhanced secretion of pro-inflammatory cytokines are the hallmark of the disease. A strictly controlled balance of antibody production and proinflammatory cytokines is the key to the healthy state. A slight tilt in this balance causes proinflammatory diseases. In RA there is an increased production of autoantibodies such as rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA), anti-cartilage type II antibodies, and etc., which have a prominent clinical significance. Furthermore, there is increased secretion of proinflammatory cytokines such as tumor necrosis factor-α (TNFα), interleukin-6 (IL-6), interleukin-1 (IL-1) which have an impact of great magnitude on the RA disease progression and severity. A better understanding of the mechanism of autoantibody production and secretion of cytokines together with crosstalk between immune cells and cytokines can provide us a better insight into the disease pathogenesis as well disease prognosis and management.
Rheumatoid Arthritis
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Author : Andrew Lemmey
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-01-11
Rheumatoid Arthritis written by Andrew Lemmey and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-11 with Medical categories.
The purpose of this book is to provide up-to-date, interesting, and thought-provoking perspectives on various aspects of research into current and potential treatments for rheumatoid arthritis (RA). This book features 16 chapters, with contributions from numerous countries (e.g. UK, USA, Japan, Sweden, Spain, Ireland, Poland, Norway), including chapters from internationally recognized leaders in rheumatology research. It is anticipated that Rheumatoid Arthritis - Etiology, Consequences and Co-Morbidities will provide both a useful reference and source of potential areas of investigation for research scientists working in the field of RA and other inflammatory arthropathies.
Immunomodulatory Functions Of Fibroblast Like Synoviocytes In Joint Inflammation And Destruction During Rheumatoid Arthritis
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Author : Hanshi Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-03
Immunomodulatory Functions Of Fibroblast Like Synoviocytes In Joint Inflammation And Destruction During Rheumatoid Arthritis written by Hanshi Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-03 with categories.