Cytokines In The Nervous System
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Cytokines In The Nervous System
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Author : Nancy J. Rothwell
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Cytokines In The Nervous System written by Nancy J. Rothwell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
Cytokines And The Cns
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Author : Richard M. Ransohoff
language : en
Publisher: CRC Press
Release Date : 2005-10-31
Cytokines And The Cns written by Richard M. Ransohoff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-31 with Medical categories.
Provides Insight into How Cytokine Action Impacts the Physiology and Pathology of the CNS. As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelera
Cytokines And The Brain
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Author :
language : en
Publisher: Elsevier
Release Date : 2008-06-18
Cytokines And The Brain written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-18 with Science categories.
This book opens a new page of neuro-immunobiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of CNS cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer’s disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment. *Opens a new page of neuro-immunobiology and provides substantive evidence for the promise of this field in the treatment of disease *Summarizes current understanding on the presence and function of central nervous system (CNS) cytokines and their receptors in a variety of CNS cells during health and disease *Includes novel approaches to the treatment of CNS disorders based on new experimental data *Offers new insight into triggers for the development of autoimmune diseases in the brain and the possibilities for treatment
Cytokines In The Nervous System
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Author : Nancy Rothwell
language : en
Publisher: Chapman & Hall
Release Date : 1996-01-01
Cytokines In The Nervous System written by Nancy Rothwell and has been published by Chapman & Hall this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-01 with Science categories.
Interleukin 1 In The Brain
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Author : Nancy J. Rothwell
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Interleukin 1 In The Brain written by Nancy J. Rothwell and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors. The main part of the book examines the different neural effects of IL-1 and the mechanisms which are involved in these actions, comparing IL-1 where possible to other inflammatory cytokines which also have neurotrophic effects. The final section evaluates the possible role of IL-1 in neural plasticity and neuronal degeneration.
Cytokines And Pain
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Author : Waldiceu A. Verri
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-28
Cytokines And Pain written by Waldiceu A. Verri and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-28 with Medical categories.
Cytokines And Pain
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Author : L.R. Watkins
language : en
Publisher: Springer
Release Date : 2013-03-08
Cytokines And Pain written by L.R. Watkins and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Medical categories.
Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.
Neurobiology Of Cytokines Part B
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Author : Errol B. DeSouza
language : en
Publisher: Academic Press
Release Date : 2013-10-22
Neurobiology Of Cytokines Part B written by Errol B. DeSouza and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
Recent data suggest a critical role for cytokines in the regulation of brain and endocrine function under normal physiological conditions. The aim of this volume and its companion Volume 16 is to provide an overview of the effects of cytokines in the brain and in the endocrine system. Methods presented for easy adaptation to new systems Comprehensive protocols included for: The synthesis and release of cytokines; The study of their central nervous system actions; Studying the role of cytokines in human neuropathological conditions
Neuro Immune Interactions In The Adult Central Nervous System
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Author : Oscar González-Pérez
language : en
Publisher: Nova Science Publishers
Release Date : 2014-03
Neuro Immune Interactions In The Adult Central Nervous System written by Oscar González-Pérez and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03 with Central nervous system categories.
Increasing evidence indicates that inflammatory cells and immunological cytokines can enter into the brain and modulate a number of biological and cognitive functions. Under physiological conditions, only a few immune cells, such as: macrophages, lymphocytes and dendritic cells can cross the blood-brain barrier and gain access to neural tissue. For many years, these findings supported the notion that the brain was an immunologically privileged organ. To date, increasing evidence strongly challenges this conjecture. In fact, neuroinflammation triggers a significant infiltration of immune cells into the cerebral parenchyma. The infiltration of inflammatory cells is accompanied by the release of a number of cytokines that target neurons, astrocytes and microglia. This interaction between the immune system and the central nervous system modulates many cerebral functions, such as: neural remodelling, synaptic plasticity, neurotransmitter releasing, stress-associated response, cognitive and mental disease progression, and others. The book summarises the latest discoveries, from basic to clinical science, regarding the interactions between the immunological mediators and the neural tissue under physiological and pathological conditions. In this book, it is discussed the influence of immune cells and cytokines in neural-regulated systems. Herein, the readers can find comprehensive descriptions in diverse fields, such as: lipids and obesity, neuronal activity, neurotransmission, stress pathogenesis, rheumatologic diseases, spinal cord injuries, regulation of neural stem cells, neural control of reproduction, and others. To ensure that most of readers obtain clear and complete information, all chapters have been written by prominent experts in their respective fields, who explain these topics with a very accessible language. In summary, this book represents a highly-updated compendium about the interactions between the central nervous system and the immune system that could be very useful for undergraduate students, postgraduate students, academic educators or trainers, basic science researchers and clinical physicians.
Inflammatory Cells And Mediators In Cns Disease
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Author : Giora Z. Feuerstein
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Inflammatory Cells And Mediators In Cns Disease written by Giora Z. Feuerstein and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Medical categories.
This book looks at the causes and long-term effects of inflammation in the CNS as a result of various conditions, and the therapeutic opportunities presented in each case. Each chapter is written by an acknowledged leader in the field